Shirley Zhu

Determination of Stromal Signatures in Breast Carcinoma (2005)

Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...

The authors used two different fibroblastic tumors to identify markers expressed by normal stroma cells (the supporting framework of body tissues and/or tumors), and show that different stromal...

Determination of Stromal Signatures in Breast Carcinoma (2005)

Robert B. West, Subbaya Subramanian, Torsten O. Nielsen, Christopher L. Corless, Brian P. Rubin, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion

Wright, Jocelyn H., Wang, Xueyan, Manning, Gerard, LaMere, Brandon J., Le, Phuong, Zhu, Shirley, ...

HGK (hepatocyte progenitor kinase-like/germinal center kinase-like kinase) is a member of the human STE20/mitogen-activated protein kinase kinase kinase kinase family of serine/threonine kinases and...

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...

Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....

The STE20 Kinase HGK Is Broadly Expressed in Human Tumor Cells and Can Modulate Cellular Transformation, Invasion, and Adhesion

Wright, Jocelyn H., Wang, Xueyan, Manning, Gerard, LaMere, Brandon J., Le, Phuong, Zhu, Shirley, ...

HGK (hepatocyte progenitor kinase-like/germinal center kinase-like kinase) is a member of the human STE20/mitogen-activated protein kinase kinase kinase kinase family of serine/threonine kinases and...

Determination of Stromal Signatures in Breast Carcinoma

West, Robert B, Nuyten, Dimitry S. A, Subramanian, Subbaya, Nielsen, Torsten O, Corless, Christopher L, Rubin, Brian P, ...

Many soft tissue tumors recapitulate features of normal connective tissue. We hypothesize that different types of fibroblastic tumors are representative of different populations of fibroblastic cells...

A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells

West, Robert B., Rubin, Brian P., Miller, Melinda A., Subramanian, Subbaya, Kaygusuz, Gulsah, Montgomery, Kelli, ...

Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations....

The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status

West, Robert B., Corless, Christopher L., Chen, Xin, Rubin, Brian P., Subramanian, Subbaya, Montgomery, Kelli, ...

We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a...

Immunoblot Analysis of CD34 Expression in Histologically Diverse Neoplasms

Natkunam, Yasodha, Rouse, Robert V., Zhu, Shirley, Fisher, Cyril, Van De Rijn, Matthijs

CD34 is a heavily glycosylated transmembrane protein of ∼110 kd whose function is essentially uncharacterized. First identified in a myeloid leukemia cell line, immunohistological reactivity with...

Gene Expression Patterns and Gene Copy Number Changes in Dermatofibrosarcoma Protuberans

Linn, Sabine C., West, Rob B., Pollack, Jonathan R., Zhu, Shirley, Hernandez-Boussard, Tina, Nielsen, Torsten O., ...

Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm. It is associated with the chromosomal translocation, t(17:22), which fuses the COL1A1 and PDGFβ genes. We determined...

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, Weihong, Putnam, Amy L., Xu-yu, Zhou, Szot, Gregory L., Lee, Michael R., Zhu, Shirley, ...

Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However, these markers have...