BAG Family Proteins: Regulators of Cancer Cell Growth Through Molecular Chaperones (1998)
BAG-1 is a novel regulator of Hsp7O family molecular chaperones. The activity of many steroid hormone receptors, including the estrogen receptor, ERalpha, is known to be regulated by Hsp70 and Hsp9O...
BAG Family Proteins: Regulators of Cancer Cell Growth Through Molecular Chaperones (1998)
BAG-family proteins regulate diverse cellular functions, including cell survival, cell proliferation, and cell motility. BAG- family proteins contain a conserved domain that allows them to bind 7O-kD...
Lo, Jeng-Fan, Hayashi, Masaaki, Woo-Kim, Sung, Tian, Bin, Huang, Jing-Feng, Fearns, Colleen, ...
Tid1 is the mammalian counterpart of the Drosophila tumor suppressor Tid56 and is also a DnaJ protein containing a conserved J domain through which it interacts with the heat shock protein 70 (Hsp70)...
Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans
Reed, John C., Doctor, Kutbuddin, Rojas, Ana, Zapata, Juan M., Stehlik, Christian, Fiorentino, Loredana, ...
Apoptosis (programmed cell death) plays important roles in many facets of normal mammalian physiology. Host-pathogen interactions have provided evolutionary pressure for apoptosis as a defense...
Essential role of Bag-1 in differentiation and survival of hematopoietic and neuronal cells
Götz, Rudolf, Wiese, Stefan, Takayama, Shinichi, Camarero, Guadalupe C., Rossoll, Wilfried, Schweizer, Ulrich, ...
By targeted gene disruption in mice, we show that Bag-1, a co-chaperone for Hsp70 which interacts with C-Raf, B-Raf, Akt, Bcl-2, steroid hormone receptors and other proteins, plays an essential role...
Lo, Jeng-Fan, Hayashi, Masaaki, Woo-Kim, Sung, Tian, Bin, Huang, Jing-Feng, Fearns, Colleen, ...
Tid1 is the mammalian counterpart of the Drosophila tumor suppressor Tid56 and is also a DnaJ protein containing a conserved J domain through which it interacts with the heat shock protein 70 (Hsp70)...
Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans
Reed, John C., Doctor, Kutbuddin, Rojas, Ana, Zapata, Juan M., Stehlik, Christian, Fiorentino, Loredana, ...
Apoptosis (programmed cell death) plays important roles in many facets of normal mammalian physiology. Host-pathogen interactions have provided evolutionary pressure for apoptosis as a defense...
A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy
Hishiya, Akinori, Iemura, Shun-ichiro, Natsume, Tohru, Takayama, Shinichi, Ikeda, Kyoji, Watanabe, Ken
The ubiquitin–proteasome system (UPS) is critical for specific degradation of cellular proteins and plays a pivotal role on protein breakdown in muscle atrophy. Here, we show that ZNF216 directly...
BAG3 Deficiency Results in Fulminant Myopathy and Early Lethality
Homma, Sachiko, Iwasaki, Masahiro, Shelton, G. Diane, Engvall, Eva, Reed, John C., Takayama, Shinichi
Bcl-2-associated athanogene 3 (BAG3) is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. Here, we show that BAG3 is prominently...