Shi-Long Lu

Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...

In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Lu, Shi-Long, Herrington, Heather, Reh, Douglas, Weber, Stephen, Bornstein, Sophia, Wang, Donna, ...

The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal...

Distinct mechanisms of TGF-β1–mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis

Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...

In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Lu, Shi-Long, Herrington, Heather, Reh, Douglas, Weber, Stephen, Bornstein, Sophia, Wang, Donna, ...

The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal...

Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression

Hoot, Kristina E., Lighthall, Jessyka, Han, Gangwen, Lu, Shi-Long, Li, Allen, Ju, Wenjun, ...

TGF-β and its signaling mediators, Smad2, -3, and -4, are involved with tumor suppression and promotion functions. Smad4–/– mouse epidermis develops spontaneous skin squamous cell carcinomas...