A Gene Wiki for Community Annotation of Gene Function (2008)
Camilo Orozco, James Goodale, Chunlei Wu, Serge Batalov, Tim J. Vickers, ...
Rines, Daniel R, Gomez-Ferreria, Maria, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
Abstract Background The mitotic spindle is a complex mechanical apparatus required for accurate segregation of sister chromosomes during mitosis. We designed a genetic screen using automated...
Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum (2006)
Claire Kidgell, Sarah K. Volkman, Johanna Daily, Justin O. Borevitz, David Plouffe, Yingyao Zhou, ...
A Systematic Map of Genetic Variation in Plasmodium falciparum (2006)
Claire Kidgell, Sarah K. Volkman, Johanna Daily, Justin O. Borevitz, David Plouffe, Yingyao Zhou, ...
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...
Complex Loci in Human and Mouse Genomes (2006)
Engström, Pär G., Suzuki, Harukazu, Ninomiya, Norika, Akalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Complex Loci in Human and Mouse Genomes (2006)
Pär G. Engström, Harukazu Suzuki, Noriko Ninomiya, Altuna Akalin, Luca Sessa, Giovanni Lavorgna, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs (2006)
Norihiro Maeda, Takeya Kasukawa, Rieko Oyama, Julian Gough, Martin Frith, Pär G. Engström, ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs (2006)
Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engstrom, Par G., ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
Complex Loci in Human and Mouse Genomes (2006)
Engstrom, Par G., Suzuki, Harukazu, Ninomiya, Noriko, Alkalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs (2006)
Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engstrom, Par G., ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
Complex Loci in Human and Mouse Genomes (2006)
Engstrom, Par G., Suzuki, Harukazu, Ninomiya, Noriko, Alkalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs (2006)
Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engstrom, Par G., ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
Complex Loci in Human and Mouse Genomes (2006)
Engstrom, Par G., Suzuki, Harukazu, Ninomiya, Noriko, Alkalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse (2004)
Mathew T. Pletcher, Philip McClurg, Serge Batalov, Andrew I. Su, S. Whitney Barnes, Erica Lagler, ...
A large resource of genetic markers, typed in 48 strains of mice, combined with statistical techniques, allow "in silico" mapping of genetic regions involved in interesting traits in mice.
Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse (2004)
Mathew T. Pletcher, Philip McClurg, Serge Batalov, Andrew I. Su, S. Whitney Barnes, Erica Lagler, ...
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic...
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Wiltshire, Tim, Pletcher, Mathew T., Batalov, Serge, Barnes, S. Whitney, Tarantino, Lisa M., Cooke, Michael P., ...
The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits,...
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates
Donaldson, Kathryn M., Li, Wei, Ching, Keith A., Batalov, Serge, Tsai, Chih-Cheng, Joazeiro, Claudio A. P.
A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding...
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, Andrew I., Wiltshire, Tim, Batalov, Serge, Lapp, Hilmar, Ching, Keith A., Block, David, ...
The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a...
Kanapin, Alexander, Batalov, Serge, Davis, Melissa J., Gough, Julian, Grimmond, Sean, Kawaji, Hideya, ...
A general overview of the protein sequence set for the mouse transcriptome produced during the FANTOM2 sequencing project is presented here. We applied different algorithms to characterize protein...
Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bono, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse
Pletcher, Mathew T, McClurg, Philip, Batalov, Serge, Su, Andrew I, Barnes, S. Whitney, Lagler, Erica, ...
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic...
Complex Loci in Human and Mouse Genomes
Engström, Pär G, Suzuki, Harukazu, Ninomiya, Noriko, Akalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs
Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engström, Pär G, ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
A Systematic Map of Genetic Variation in Plasmodium falciparum
Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...
Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum
Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Wiltshire, Tim, Pletcher, Mathew T., Batalov, Serge, Barnes, S. Whitney, Tarantino, Lisa M., Cooke, Michael P., ...
The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits,...
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates
Donaldson, Kathryn M., Li, Wei, Ching, Keith A., Batalov, Serge, Tsai, Chih-Cheng, Joazeiro, Claudio A. P.
A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding...
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, Andrew I., Wiltshire, Tim, Batalov, Serge, Lapp, Hilmar, Ching, Keith A., Block, David, ...
The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a...
Kanapin, Alexander, Batalov, Serge, Davis, Melissa J., Gough, Julian, Grimmond, Sean, Kawaji, Hideya, ...
A general overview of the protein sequence set for the mouse transcriptome produced during the FANTOM2 sequencing project is presented here. We applied different algorithms to characterize protein...
Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
Gustincich, Stefano, Batalov, Serge, Beisel, Kirk W., Bono, Hidemasa, Carninci, Piero, Fletcher, Colin F., ...
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse
Pletcher, Mathew T, McClurg, Philip, Batalov, Serge, Su, Andrew I, Barnes, S. Whitney, Lagler, Erica, ...
Rapid expansion of available data, both phenotypic and genotypic, for multiple strains of mice has enabled the development of new methods to interrogate the mouse genome for functional genetic...
Complex Loci in Human and Mouse Genomes
Engström, Pär G, Suzuki, Harukazu, Ninomiya, Noriko, Akalin, Altuna, Sessa, Luca, Lavorgna, Giovanni, ...
Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core...
Transcript Annotation in FANTOM3: Mouse Gene Catalog Based on Physical cDNAs
Maeda, Norihiro, Kasukawa, Takeya, Oyama, Rieko, Gough, Julian, Frith, Martin, Engström, Pär G, ...
The international FANTOM consortium aims to produce a comprehensive picture of the mammalian transcriptome, based upon an extensive cDNA collection and functional annotation of full-length enriched...
A Systematic Map of Genetic Variation in Plasmodium falciparum
Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...
Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum
Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...
Genome-wide functional analysis of human cell-cycle regulators
Mukherji, Mridul, Bell, Russell, Supekova, Lubica, Wang, Yan, Orth, Anthony P., Batalov, Serge, ...
Human cells have evolved complex signaling networks to coordinate the cell cycle. A detailed understanding of the global regulation of this fundamental process requires comprehensive identification...
Genomewide Association Analysis in Diverse Inbred Mice: Power and Population Structure
McClurg, Phillip, Janes, Jeff, Wu, Chunlei, Delano, David L., Walker, John R., Batalov, Serge, ...
The discovery of quantitative trait loci (QTL) in model organisms has relied heavily on the ability to perform controlled breeding to generate genotypic and phenotypic diversity. Recently, we and...
Li, Wei, Bengtson, Mario H., Ulbrich, Axel, Matsuda, Akio, Reddy, Venkateshwar A., Orth, Anthony, ...
Specificity of protein ubiquitylation is conferred by E3 ubiquitin (Ub) ligases. We have annotated ∼617 putative E3s and substrate-recognition subunits of E3 complexes encoded in the human genome....
Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators
Wu, Chunlei, Delano, David L., Mitro, Nico, Su, Stephen V., Janes, Jeff, McClurg, Phillip, ...
Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene...
Rines, Daniel R, Gomez-Ferreria, Maria Ana, Zhou, Yingyao, DeJesus, Paul, Grob, Seanna, Batalov, Serge, ...
A loss-of-function screen for siRNAs that arrest human cells in metaphase reveals genes involved in mitotic spindle integrity.
A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway
Amelio, Antonio L., Miraglia, Loren J., Conkright, Juliana J., Mercer, Becky A., Batalov, Serge, Cavett, Valerie, ...
Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses. Coactivator proteins function prominently in these pathways as the conduit to the basic...
A Gene Wiki for Community Annotation of Gene Function
Huss, Jon W, Orozco, Camilo, Goodale, James, Wu, Chunlei, Batalov, Serge, Vickers, Tim J, ...
This manuscript describes the creation of comprehensive gene wiki, seeded with data from public domain sources, which will enable and encourage community annotation of gene function.