Amelie M. Lutz, Juergen K. Willmann, Frank V. Cochran, Pritha Ray, Sanjiv S. Gambhir
BackgroundIncreasing efforts and financial resources are being invested in early cancer detection research. Blood assays detecting tumor biomarkers promise noninvasive and financially reasonable...
Quantum dot imaging for embryonic stem cells (2007)
Lin, Shuan, Xie, Xiaoyan, Patel, Manishkumar R, Yang, Yao-Hung, Li, Zongjin, Cao, Feng, ...
Abstract Background Semiconductor quantum dots (QDs) hold increasing potential for cellular imaging both in vitro and in vivo . In this report, we aimed to evaluate in vivo multiplex imaging of mouse...
New Gene Based Probes for Imaging Breast Cancer with PET (1998)
We are developing methods to image her-2-neu oncogene over-expression in breast cancer using positron emission tomography (PET). Small oligodeoxynucleotides (ODNs) that are complementary to the...
Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., ...
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report...
Gambhir, Sanjiv S., Barrio, Jorge R., Phelps, Michael E., Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, ...
We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting...
Wu, Anna M., Yazaki, Paul J., Tsai, Shih-wa, Nguyen, Khoi, Anderson, Anne-Line, McCarthy, Deborah W., ...
Rapid imaging by antitumor antibodies has been limited by the prolonged targeting kinetics and clearance of labeled whole antibodies. Genetically engineered fragments with rapid access and high...
Quantitative imaging of the T cell antitumor response by positron-emission tomography
Dubey, Purnima, Su, Helen, Adonai, Nona, Du, Shouying, Rosato, Antonio, Braun, Jonathan, ...
We describe a noninvasive, quantitative, and tomographic method to visualize lymphocytes within the whole animal. We used positron-emission tomography (PET) to follow the localization of adoptively...
Decision Analysis for the Cost-Effective Management of Recurrent Colorectal Cancer
Park, Kenneth C., Schwimmer, Judy, Shepherd, James E., Phelps, Michael E., Czernin, Johannes R., Schiepers, Christiaan, ...
Visualization of a primary anti-tumor immune response by positron emission tomography
Shu, Chengyi J., Guo, Shuling, Kim, Young J., Shelly, Stephanie M., Nijagal, Amar, Ray, Pritha, ...
Current methodologies that monitor immune responses rely on invasive techniques that sample tissues at a given point in time. New technologies are needed to elucidate the temporal patterns of immune...
Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., ...
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report...
Gambhir, Sanjiv S., Barrio, Jorge R., Phelps, Michael E., Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, ...
We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting...
Wu, Anna M., Yazaki, Paul J., Tsai, Shih-wa, Nguyen, Khoi, Anderson, Anne-Line, McCarthy, Deborah W., ...
Rapid imaging by antitumor antibodies has been limited by the prolonged targeting kinetics and clearance of labeled whole antibodies. Genetically engineered fragments with rapid access and high...
Quantitative imaging of the T cell antitumor response by positron-emission tomography
Dubey, Purnima, Su, Helen, Adonai, Nona, Du, Shouying, Rosato, Antonio, Braun, Jonathan, ...
We describe a noninvasive, quantitative, and tomographic method to visualize lymphocytes within the whole animal. We used positron-emission tomography (PET) to follow the localization of adoptively...
Visualization of a primary anti-tumor immune response by positron emission tomography
Shu, Chengyi J., Guo, Shuling, Kim, Young J., Shelly, Stephanie M., Nijagal, Amar, Ray, Pritha, ...
Current methodologies that monitor immune responses rely on invasive techniques that sample tissues at a given point in time. New technologies are needed to elucidate the temporal patterns of immune...
Decision Analysis for the Cost-Effective Management of Recurrent Colorectal Cancer
Park, Kenneth C., Schwimmer, Judy, Shepherd, James E., Phelps, Michael E., Czernin, Johannes R., Schiepers, Christiaan, ...
An intramolecular folding sensor for imaging estrogen receptor–ligand interactions
Paulmurugan, Ramasamy, Gambhir, Sanjiv S.
Strategies for high-throughput analysis of interactions between various hormones and drugs with the estrogen receptor (ER) are crucial for accelerating the understanding of ER biology and...
Luo, Jian, Ho, Peggy P., Buckwalter, Marion S., Hsu, Tiffany, Lee, Lowen Y., Zhang, Hui, ...
Autoimmune encephalomyelitis, a mouse model for multiple sclerosis, is characterized by the activation of immune cells, demyelination of axons in the CNS, and paralysis. We found that TGF-β1...
Quantum dot imaging for embryonic stem cells
Lin, Shuan, Xie, Xiaoyan, Patel, Manishkumar R, Yang, Yao-Hung, Li, Zongjin, Cao, Feng, ...
Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes
Lutz, Amelie M, Willmann, Juergen K, Cochran, Frank V, Ray, Pritha, Gambhir, Sanjiv S
Sanjiv Gambhir and colleagues describe a linear one-compartment mathematical model that allows estimation of minimal detectable tumor sizes based on blood tumor biomarker assays.
Transcriptional and Functional Profiling of Human Embryonic Stem Cell-Derived Cardiomyocytes
Cao, Feng, Wagner, Roger A., Wilson, Kitchener D., Xie, Xiaoyan, Fu, Ji-Dong, Drukker, Micha, ...
Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we investigate the use of human embryonic stem...