Ramanuj DasGupta

A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila (2007)

DasGupta, Ramanuj, Nybakken, Kent, Booker, Matthew, Mathey-Prevot, Bernard, Gonsalves, Foster, Changkakoty, Binita, ...

Abstract Off-target effects have been demonstrated to be a major source of false-positives in RNA interference (RNAi) high-throughput screens. In this study, we re-assess the previously published...

Multiple roles for activated beta-catenin/Lef1/Tcf transcription complexes during hair organogenesis and hair cycling / (2002)

Dasgupta, Ramanuj.

Thesis (Ph. D.)--University of Chicago, Committee-on-Developmental Biology, 2002.

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

Merrill, Bradley J., Gat, Uri, DasGupta, Ramanuj, Fuchs, Elaine

In skin, multipotent stem cells generate the keratinocytes of the epidermis, sebaceous gland, and hair follicles. In this paper, we show that Tcf3 and Lef1 control these differentiation lineages. In...

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

Merrill, Bradley J., Gat, Uri, DasGupta, Ramanuj, Fuchs, Elaine

In skin, multipotent stem cells generate the keratinocytes of the epidermis, sebaceous gland, and hair follicles. In this paper, we show that Tcf3 and Lef1 control these differentiation lineages. In...

A developmental conundrum: a stabilized form of β-catenin lacking the transcriptional activation domain triggers features of hair cell fate in epidermal cells and epidermal cell fate in hair follicle cells

DasGupta, Ramanuj, Rhee, Horace, Fuchs, Elaine

Wnt signaling orchestrates morphogenetic processes in which changes in gene expression are associated with dramatic changes in cell organization within developing tissue/organss. Upon signaling,...

A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila

DasGupta, Ramanuj, Nybakken, Kent, Booker, Matthew, Mathey-Prevot, Bernard, Gonsalves, Foster, Changkakoty, Binita, ...

A second generation dsRNA library was used to re-assess factors that influence the outcome of transcriptional reporter-based whole-genome RNAi screens for the Wnt/Wingless (wg) and Hedgehog...