Raffi Gugasyan

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells (2002)

Pohl, Thomas, Gugasyan, Raffi, Grumont, Raelene J., Strasser, Andreas, Metcalf, Donald, Tarlinton, David, ...

Transcription factors NF-KB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells. Redundancy among Rel/ NF-KB...

The immunosuppressive potential and mode of action of 2-acetyl-4-tetrahydroxybutyl imidazole (THI) (1996)

Gugasyan, Raffi.

Typescript (photocopy) Erratum inserted. Includes bibliographical references (leaves 171-201)

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

Pohl, Thomas, Gugasyan, Raffi, Grumont, Raelene J., Strasser, Andreas, Metcalf, Donald, Tarlinton, David, ...

Transcription factors NF-κB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells. Redundancy among Rel/NF-κB...

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

Grossmann, Mathis, O’Reilly, Lorraine A., Gugasyan, Raffi, Strasser, Andreas, Adams, Jerry M., Gerondakis, Steve

Rel and RelA, individually dispensable for lymphopoiesis, serve unique functions in activated B and T cells. Here their combined roles in lymphocyte development were examined in chimeric mice...

The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms

Gugasyan, Raffi, Voss, Anne, Varigos, George, Thomas, Tim, Grumont, Raelene J., Kaur, Pritinder, ...

Determining the roles of Rel/NF-κB transcription factors in mouse skin development with loss-of-function mutants has been limited by redundancy among these proteins and by embryonic lethality...

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

Banerjee, Ashish, Gugasyan, Raffi, McMahon, Martin, Gerondakis, Steve

Engaging mammalian Toll-like receptors (TLRs) activate both the NF-κB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels...

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

Thomas, Tim, Corcoran, Lynn M., Gugasyan, Raffi, Dixon, Mathew P., Brodnicki, Thomas, Nutt, Stephen L., ...

Monocytic leukemia zinc finger protein (MOZ), a transcriptional coactivator and member of the MYST family of histone acetyltransferases, is the target of recurrent translocations in acute myeloid...

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

Pohl, Thomas, Gugasyan, Raffi, Grumont, Raelene J., Strasser, Andreas, Metcalf, Donald, Tarlinton, David, ...

Transcription factors NF-κB1 and c-Rel, individually dispensable during embryogenesis, serve similar, yet distinct, roles in the function of mature hemopoietic cells. Redundancy among Rel/NF-κB...

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

Grossmann, Mathis, O’Reilly, Lorraine A., Gugasyan, Raffi, Strasser, Andreas, Adams, Jerry M., Gerondakis, Steve

Rel and RelA, individually dispensable for lymphopoiesis, serve unique functions in activated B and T cells. Here their combined roles in lymphocyte development were examined in chimeric mice...

The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms

Gugasyan, Raffi, Voss, Anne, Varigos, George, Thomas, Tim, Grumont, Raelene J., Kaur, Pritinder, ...

Determining the roles of Rel/NF-κB transcription factors in mouse skin development with loss-of-function mutants has been limited by redundancy among these proteins and by embryonic lethality...

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

Banerjee, Ashish, Gugasyan, Raffi, McMahon, Martin, Gerondakis, Steve

Engaging mammalian Toll-like receptors (TLRs) activate both the NF-κB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels...

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

Thomas, Tim, Corcoran, Lynn M., Gugasyan, Raffi, Dixon, Mathew P., Brodnicki, Thomas, Nutt, Stephen L., ...

Monocytic leukemia zinc finger protein (MOZ), a transcriptional coactivator and member of the MYST family of histone acetyltransferases, is the target of recurrent translocations in acute myeloid...

C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription

Grumont, Raelene, Hochrein, Hubertus, O'Keeffe, Meredith, Gugasyan, Raffi, White, Christine, Caminschi, Irina, ...

Interleukin 12 (IL-12) is a 70-kD proinflammatory cytokine produced by antigen presenting cells that is essential for the induction of T helper type 1 development. It comprises 35-kD (p35) and 40-kD...

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites

Gugasyan, Raffi, Quilici, Cathy, I, Stacey T.T., Grail, Dianne, Verhagen, Anne M., Roberts, Andrew, ...

Downstream of kinase (Dok)–related protein (DokR, also known as p56dok/FRIP/Dok-R) is implicated in cytokine and immunoreceptor signaling in myeloid and T cells. Tyrosine phosphorylation induces...