The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle (2007)
Youbin Xiang, Satomi Takeo, Laurence Florens, Stacie E. Hughes, Li-Jun Huo, William D. Gilliland, ...
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can...
The Multiple Roles of Mps1 in Drosophila Female Meiosis (2007)
William D. Gilliland, Stacie E. Hughes, Jeffrey L. Cotitta, Satomi Takeo, Youbin Xiang, R. Scott Hawley
The Drosophila gene ald encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Using live imaging, we...
The Multiple Roles of Mps1 in Drosophila Female Meiosis (2007)
William Dean Gilliland, Stacie E. Hughes, Jeffrey L. Cotitta, Satomi Takeo, Youbin Xiang, R. Scott Hawley
The Drosophila gene ald encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Loss of this checkpoint...
Hawley, R Scott, Gilbert, SP, Matthies, HJG, Gustafson, SM, Sproul, LR, Cui, W
Nod, a nonmotile kinesinlike protein, plays a critical role in segregating achiasmate chromosomes during female meiosis. In addition to localizing to oocyte chromosomes, we show that functional...
Wei J. Gong, Kim S. McKim, R. Scott Hawley
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog. We have utilized the LacI-GFP:...
Wei J. Gong, Kim McKim, R. Scott Hawley
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog. We have utilized the LacI-GFP:...
Anderson, Lorinda K., Royer, Suzanne M., Page, Scott L., McKim, Kim S., Lai, Ann, Lilly, Mary A., ...
The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination in most organisms, but its exact role remains enigmatic. One reason for this uncertainty is that the...
Anderson, Lorinda K., Royer, Suzanne M., Page, Scott L., McKim, Kim S., Lai, Ann, Lilly, Mary A., ...
The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination in most organisms, but its exact role remains enigmatic. One reason for this uncertainty is that the...
Chromosome choreography: The meiotic ballet (2003)
Page, Scott L., Hawley, R. Scott
The separation of homologous chromosomes during meiosis in eukaryotes is the physical basis of Mendelian inheritance. The core of the meiotic process is a specialized nuclear division (meiosis I) in...
Chromosome choreography : the meiotic ballet (2003)
Page, Scott L., Hawley, R. Scott
The separation of homologous chromosomes during meiosis in eukaryotes is the physical basis of Mendelian inheritance. The core of the meiotic process is a specialized nuclear division (meiosis I) in...
Analysis of Meiosis in Fixed and Live Oocytes by Light Microscopy (2000)
Matthies, Heinrich JG, Clarkson, Michael John, Saint, Robert Bryce, Namba, Ruria, Hawley, R Scott
Analysis of Meiosis in Fixed and Live Oocytes by Light Microscopy (2000)
Matthies, Heinrich JG, Clarkson, Michael John, Saint, Robert Bryce, Namba, Ruria, Hawley, R Scott
Orphan Kinesin NOD Lacks Motile Properties But Does Possess a Microtubule-stimulated ATPase Activity
Matthies, Heinrich J.G., Baskin, Ronald J., Hawley, R. Scott
NOD is a Drosophila chromosome-associated kinesin-like protein that does not fall into the chromokinesin subfamily. Although NOD lacks residues known to be critical for kinesin function, we show that...
mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.
Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...
Anderson, Lorinda K., Royer, Suzanne M., Page, Scott L., McKim, Kim S., Lai, Ann, Lilly, Mary A., ...
The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination in most organisms, but its exact role remains enigmatic. One reason for this uncertainty is that the...
All Paired Up with No Place to Go: Pairing, Synapsis, and DSB Formation in a Balancer Heterozygote
Gong, Wei J, McKim, Kim S, Hawley, R. Scott
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog. We have utilized the LacI-GFP:...
c(3)G encodes a Drosophila synaptonemal complex protein
Page, Scott L., Hawley, R. Scott
The meiotic mutant c(3)G (crossover suppressor on 3 of Gowen) abolishes both synaptonemal complex (SC) formation and meiotic recombination, whereas mutations in the mei-W68 and mei-P22 genes prevent...
The Effect of mei-41 on Rdna Redundancy in DROSOPHILA MELANOGASTER
Hawley, R. Scott, Tartof, Kenneth D.
The recombination and repair defective mutant, mei-41, exhibits three rather striking effects on the genetic properties and chromosomal stability of rDNA in Drosophila. First, mei-41 inhibits rDNA...
A Two-Stage Model for the Control of rDNA Magnification
Hawley, R. Scott, Tartof, Kenneth D.
Males of the genotype bb/Ybb- have been shown to produce both magnified (bbm+) and, less frequently, reduced (bbrl) X chromosomes. An analysis of the progeny of single magnifying bb/Ybb- males...
Marcus, Craig H., Zitron, Anne E., Wright, David A., Hawley, R. Scott
rDNA magnification in Drosophila melanogaster is defined experimentally as the ability of bb/Ybb- males to produce exceptional progeny that are wild type with respect to rDNA associated phenotypes....
Meiotic exchange was measured in females heterozygous for a normal sequence X chromosome and for each of eleven T(1;4)s and each of sixteen T(1;Y)s. The results indicate that the X chromosome can be...
Page, Scott L., Hawley, R. Scott
The semisterile meiotic mutant mei-352 alters the distribution of meiotic exchanges without greatly affecting their total frequency. We show that the mei-352 mutation is an allele of the klp3A gene,...
Nod is a chromokinesin-like protein that plays a critical role in segregating achiasmate chromosomes during female meiosis. The C-terminal half of the Nod protein contains two putative DNA-binding...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
Harris, David, Orme, Charisse, Kramer, Joseph, Namba, Luria, Champion, Mia, Palladino, Michael J, ...
In Drosophila oocytes, euchromatic homolog-homolog associations are released at the end of pachytene, while heterochromatic pairings persist until metaphase I. A screen of 123 autosomal deficiencies...
A large-scale screen for mutagen-sensitive loci in Drosophila.
Laurencon, Anne, Orme, Charisse M, Peters, Heather K, Boulton, Christina L, Vladar, Eszter K, Langley, Sasha A, ...
In a screen for new DNA repair mutants, we tested 6275 Drosophila strains bearing homozygous mutagenized autosomes (obtained from C. Zuker) for hypersensitivity to methyl methanesulfonate (MMS) and...
The Mechanism of Secondary Nondisjunction in Drosophila melanogaster Females
Xiang, Youbin, Hawley, R. Scott
Bridges (1916) observed that X chromosome nondisjunction was much more frequent in XXY females than it was in genetically normal XX females. In addition, virtually all cases of X nondisjunction in...
Hawley, R. Scott, Gilliland, William D.
It is standard genetic practice to determine whether or not two independently obtained mutants define the same or different genes by performing the complementation test. While the complementation...
Orphan Kinesin NOD Lacks Motile Properties But Does Possess a Microtubule-stimulated ATPase Activity
Matthies, Heinrich J.G., Baskin, Ronald J., Hawley, R. Scott
NOD is a Drosophila chromosome-associated kinesin-like protein that does not fall into the chromokinesin subfamily. Although NOD lacks residues known to be critical for kinesin function, we show that...
c(3)G encodes a Drosophila synaptonemal complex protein
Page, Scott L., Hawley, R. Scott
The meiotic mutant c(3)G (crossover suppressor on 3 of Gowen) abolishes both synaptonemal complex (SC) formation and meiotic recombination, whereas mutations in the mei-W68 and mei-P22 genes prevent...
mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.
Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...
Anderson, Lorinda K., Royer, Suzanne M., Page, Scott L., McKim, Kim S., Lai, Ann, Lilly, Mary A., ...
The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination in most organisms, but its exact role remains enigmatic. One reason for this uncertainty is that the...
The Effect of mei-41 on Rdna Redundancy in DROSOPHILA MELANOGASTER
Hawley, R. Scott, Tartof, Kenneth D.
The recombination and repair defective mutant, mei-41, exhibits three rather striking effects on the genetic properties and chromosomal stability of rDNA in Drosophila. First, mei-41 inhibits rDNA...
A Two-Stage Model for the Control of rDNA Magnification
Hawley, R. Scott, Tartof, Kenneth D.
Males of the genotype bb/Ybb- have been shown to produce both magnified (bbm+) and, less frequently, reduced (bbrl) X chromosomes. An analysis of the progeny of single magnifying bb/Ybb- males...
Marcus, Craig H., Zitron, Anne E., Wright, David A., Hawley, R. Scott
rDNA magnification in Drosophila melanogaster is defined experimentally as the ability of bb/Ybb- males to produce exceptional progeny that are wild type with respect to rDNA associated phenotypes....
Meiotic exchange was measured in females heterozygous for a normal sequence X chromosome and for each of eleven T(1;4)s and each of sixteen T(1;Y)s. The results indicate that the X chromosome can be...
All Paired Up with No Place to Go: Pairing, Synapsis, and DSB Formation in a Balancer Heterozygote
Gong, Wei J, McKim, Kim S, Hawley, R. Scott
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog. We have utilized the LacI-GFP:...
Page, Scott L., Hawley, R. Scott
The semisterile meiotic mutant mei-352 alters the distribution of meiotic exchanges without greatly affecting their total frequency. We show that the mei-352 mutation is an allele of the klp3A gene,...
Nod is a chromokinesin-like protein that plays a critical role in segregating achiasmate chromosomes during female meiosis. The C-terminal half of the Nod protein contains two putative DNA-binding...
Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.
Laurençon, Anne, Purdy, Amanda, Sekelsky, Jeff, Hawley, R Scott, Su, Tin Tin
ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing...
Harris, David, Orme, Charisse, Kramer, Joseph, Namba, Luria, Champion, Mia, Palladino, Michael J, ...
In Drosophila oocytes, euchromatic homolog-homolog associations are released at the end of pachytene, while heterochromatic pairings persist until metaphase I. A screen of 123 autosomal deficiencies...
A large-scale screen for mutagen-sensitive loci in Drosophila.
Laurencon, Anne, Orme, Charisse M, Peters, Heather K, Boulton, Christina L, Vladar, Eszter K, Langley, Sasha A, ...
In a screen for new DNA repair mutants, we tested 6275 Drosophila strains bearing homozygous mutagenized autosomes (obtained from C. Zuker) for hypersensitivity to methyl methanesulfonate (MMS) and...
The Mechanism of Secondary Nondisjunction in Drosophila melanogaster Females
Xiang, Youbin, Hawley, R. Scott
Bridges (1916) observed that X chromosome nondisjunction was much more frequent in XXY females than it was in genetically normal XX females. In addition, virtually all cases of X nondisjunction in...
Hawley, R. Scott, Gilliland, William D.
It is standard genetic practice to determine whether or not two independently obtained mutants define the same or different genes by performing the complementation test. While the complementation...
The Multiple Roles of Mps1 in Drosophila Female Meiosis
Gilliland, William D, Hughes, Stacie E, Cotitta, Jeffrey L, Takeo, Satomi, Xiang, Youbin, Hawley, R. Scott
The Drosophila gene ald encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Using live imaging, we...
Lake, Cathleen M., Teeter, Kathy, Page, Scott L., Nielsen, Rachel, Hawley, R. Scott
Members of the minichromosome maintenance (MCM) family have pivotal roles in many biological processes. Although originally studied for their role in DNA replication, it is becoming increasingly...
The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle
Xiang, Youbin, Takeo, Satomi, Florens, Laurence, Hughes, Stacie E, Huo, Li-Jun, Gilliland, William D, ...
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can...
Jeffress, Jennifer K., Page, Scott L., Royer, Suzanne M., Belden, Elizabeth D., Blumenstiel, Justin P., Anderson, Lorinda K., ...
In Drosophila melanogaster oocytes, the C(3)G protein comprises the transverse filaments (TFs) of the synaptonemal complex (SC). Like other TF proteins, such as Zip1p in yeast and SCP1 in mammals,...
Matthies, Heinrich J.G., Messina, Lisa G., Namba, Ruria, Greer, Kimberly J., Walker, M.Y., Hawley, R. Scott
Drosophila melanogaster oocytes heterozygous for mutations in the α-tubulin 67C gene (αtub67C) display defects in centromere positioning during prometaphase of meiosis I. The centromeres do not...