Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members
Jiang, Qiong, Li, Wen Qing, Hofmeister, Robert R., Young, Howard A., Hodge, David R., Keller, Jonathan R., ...
The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation of three members of the Bcl2 family: synthesis of Bcl2, phosphorylation of Bad, and cytosolic retention of...
Stat5a/b are essential for normal lymphoid development and differentiation
Yao, Zhengju, Cui, Yongzhi, Watford, Wendy T., Bream, Jay H., Yamaoka, Kunihiro, Hissong, Bruce D., ...
Cytokines that use the common gamma chain γc are critical for lymphoid development and function. Mutations of the IL-7 receptor, γc, or its associated kinase, Jak3, are the major cause of human...
Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members
Jiang, Qiong, Li, Wen Qing, Hofmeister, Robert R., Young, Howard A., Hodge, David R., Keller, Jonathan R., ...
The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation of three members of the Bcl2 family: synthesis of Bcl2, phosphorylation of Bad, and cytosolic retention of...
Stat5a/b are essential for normal lymphoid development and differentiation
Yao, Zhengju, Cui, Yongzhi, Watford, Wendy T., Bream, Jay H., Yamaoka, Kunihiro, Hissong, Bruce D., ...
Cytokines that use the common gamma chain γc are critical for lymphoid development and function. Mutations of the IL-7 receptor, γc, or its associated kinase, Jak3, are the major cause of human...
Lsh is involved in de novo methylation of DNA
Zhu, Heming, Geiman, Theresa M, Xi, Sichuan, Jiang, Qiong, Schmidtmann, Anja, Chen, Taiping, ...
Deletion of Lsh perturbs DNA methylation patterns in mice yet it is unknown whether Lsh plays a direct role in the methylation process. Two types of methylation pathways have been distinguished:...
IL-7 promotes T cell proliferation through destabilization of p27Kip1
Li, Wen Qing, Jiang, Qiong, Aleem, Eiman, Kaldis, Philipp, Khaled, Annette R., Durum, Scott K.
Interleukin (IL)-7 is required for survival and homeostatic proliferation of T lymphocytes. The survival effect of IL-7 is primarily through regulation of Bcl-2 family members; however, the...