Bernhagen, Jurgen, Krohn, Regina, Lue, Hongqi, Gregory, J. L., Zernecke, Alma, Koenen, Rory R., ...
© 2007 Nature Publishing Group
Bernhagen, Jurgen, Krohn, Regina, Lue, Hongqi, Gregory, J. L., Zernecke, Alma, Koenen, Rory R., ...
© 2007 Nature Publishing Group
Redox regulation of chemokine receptor expression
Saccani, Alessandra, Saccani, Simona, Orlando, Simone, Sironi, Marina, Bernasconi, Sergio, Ghezzi, Pietro, ...
Cytokines and reactive oxygen intermediates (ROI) are frequent companions at sites of acute inflammation. We have shown previously that in human monocytes, bacterial lipopolysaccharide, IL-1, and...
Alheim, Katarina, Chai, Zhen, Fantuzzi, Giamila, Hasanvan, Homa, Malinowsky, David, Di Santo, Elena, ...
IL-1β is an endogenous pyrogen that is induced during systemic lipopolysaccharide (LPS)- or IL-1-induced fever. We have examined the fever and cytokine responses following i.p. injection of IL-1...
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Brines, Michael L., Ghezzi, Pietro, Keenan, Sonja, Agnello, Davide, De Lanerolle, Nihal C., Cerami, Carla, ...
Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain. We...
Nakamura, Hajime, De Rosa, Stephen C., Yodoi, Junji, Holmgren, Arne, Ghezzi, Pietro, Herzenberg, Leonard A., ...
Thioredoxin (Trx) is an intracellular redox protein with extracellular cytokine-like and chemokine-like activities. We show here that, although plasma Trx levels are unrelated to survival of...
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Sirén, Anna-Leena, Fratelli, Maddalena, Brines, Michael, Goemans, Christoph, Casagrande, Simona, Lewczuk, Piotr, ...
Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms. Apoptosis and necrosis have been proposed as mechanisms of cellular demise,...
Fratelli, Maddalena, Demol, Hans, Puype, Magda, Casagrande, Simona, Eberini, Ivano, Salmona, Mario, ...
Formation of mixed disulfides between glutathione and the cysteines of some proteins (glutathionylation) has been suggested as a mechanism through which protein functions can be regulated by the...
Casagrande, Simona, Bonetto, Valentina, Fratelli, Maddalena, Gianazza, Elisabetta, Eberini, Ivano, Massignan, Tania, ...
To identify proteins undergoing glutathionylation (formation of protein-glutathione mixed disulfides) in human T cell blasts, we radiolabeled the glutathione pool with 35S, exposed cells to the...
Calvillo, Laura, Latini, Roberto, Kajstura, Jan, Leri, Annarosa, Anversa, Piero, Ghezzi, Pietro, ...
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting erythrocyte survival and differentiation, is a member of the large and diverse cytokine superfamily. Recent...
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erbayraktar, Serhat, Grasso, Giovanni, Sfacteria, Alessandra, Xie, Qiao-wen, Coleman, Thomas, Kreilgaard, Mads, ...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects...
Laragione, Teresa, Bonetto, Valentina, Casoni, Filippo, Massignan, Tania, Bianchi, Giancarlo, Gianazza, Elisabetta, ...
Thiols affect a variety of cell functions, an effect known as redox regulation. We show here that treatment (1–2 h) of cells with 0.1–5 mM N-acetyl-l-cysteine (NAC) increases surface protein...
Erythropoietin both protects from and reverses experimental diabetic neuropathy
Bianchi, Roberto, Buyukakilli, Belgin, Brines, Michael, Savino, Costanza, Cavaletti, Guido, Oggioni, Norberto, ...
Erythropoietin (EPO) possesses generalized neuroprotective and neurotrophic actions. We tested the efficacy of recombinant human EPO (rhEPO) in preventing and reversing nerve dysfunction in...
Gene expression profiling reveals a signaling role of glutathione in redox regulation
Fratelli, Maddalena, Goodwin, Leslie O., Ørom, Ulf Andersson, Lombardi, Sarah, Tonelli, Rossella, Mengozzi, Manuela, ...
Proteins can form reversible mixed disulfides with glutathione (GSH). It has been hypothesized that protein glutathionylation may represent a mechanism of redox regulation, in a fashion similar to...
Bertini, Riccardo, Allegretti, Marcello, Bizzarri, Cinzia, Moriconi, Alessio, Locati, Massimo, Zampella, Giuseppe, ...
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique...
Brines, Michael, Grasso, Giovanni, Fiordaliso, Fabio, Sfacteria, Alessandra, Ghezzi, Pietro, Fratelli, Maddalena, ...
The cytokine erythropoietin (Epo) is tissue-protective in preclinical models of ischemic, traumatic, toxic, and inflammatory injuries. We have recently characterized Epo derivatives that do not bind...
Fiordaliso, Fabio, Chimenti, Stefano, Staszewsky, Lidia, Bai, Antonio, Carlo, Eleonora, Cuccovillo, Ivan, ...
The cytokine erythropoietin (EPO) protects the heart from ischemic injury, in part by preventing apoptosis. However, EPO administration can also raise the hemoglobin concentration, which, by...
Coleman, Thomas R., Westenfelder, Christof, Tögel, Florian E., Yang, Ying, Hu, Zhuma, Swenson, LeAnne, ...
Recombinant human erythropoietin (rhEPO) is receiving increasing attention as a potential therapy for prevention of injury and restoration of function in nonhematopoietic tissues. However, the...
Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
Mennini, Tiziana, De Paola, Massimiliano, Bigini, Paolo, Mastrotto, Cristina, Fumagalli, Elena, Barbera, Sara, ...
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the...
Redox regulation of chemokine receptor expression
Saccani, Alessandra, Saccani, Simona, Orlando, Simone, Sironi, Marina, Bernasconi, Sergio, Ghezzi, Pietro, ...
Cytokines and reactive oxygen intermediates (ROI) are frequent companions at sites of acute inflammation. We have shown previously that in human monocytes, bacterial lipopolysaccharide, IL-1, and...
Alheim, Katarina, Chai, Zhen, Fantuzzi, Giamila, Hasanvan, Homa, Malinowsky, David, Di Santo, Elena, ...
IL-1β is an endogenous pyrogen that is induced during systemic lipopolysaccharide (LPS)- or IL-1-induced fever. We have examined the fever and cytokine responses following i.p. injection of IL-1...
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Brines, Michael L., Ghezzi, Pietro, Keenan, Sonja, Agnello, Davide, De Lanerolle, Nihal C., Cerami, Carla, ...
Erythropoietin (EPO), recognized for its central role in erythropoiesis, also mediates neuroprotection when the recombinant form (r-Hu-EPO) is directly injected into ischemic rodent brain. We...
Nakamura, Hajime, De Rosa, Stephen C., Yodoi, Junji, Holmgren, Arne, Ghezzi, Pietro, Herzenberg, Leonard A., ...
Thioredoxin (Trx) is an intracellular redox protein with extracellular cytokine-like and chemokine-like activities. We show here that, although plasma Trx levels are unrelated to survival of...
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Sirén, Anna-Leena, Fratelli, Maddalena, Brines, Michael, Goemans, Christoph, Casagrande, Simona, Lewczuk, Piotr, ...
Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults by largely unknown mechanisms. Apoptosis and necrosis have been proposed as mechanisms of cellular demise,...
Fratelli, Maddalena, Demol, Hans, Puype, Magda, Casagrande, Simona, Eberini, Ivano, Salmona, Mario, ...
Formation of mixed disulfides between glutathione and the cysteines of some proteins (glutathionylation) has been suggested as a mechanism through which protein functions can be regulated by the...
Casagrande, Simona, Bonetto, Valentina, Fratelli, Maddalena, Gianazza, Elisabetta, Eberini, Ivano, Massignan, Tania, ...
To identify proteins undergoing glutathionylation (formation of protein-glutathione mixed disulfides) in human T cell blasts, we radiolabeled the glutathione pool with 35S, exposed cells to the...
Calvillo, Laura, Latini, Roberto, Kajstura, Jan, Leri, Annarosa, Anversa, Piero, Ghezzi, Pietro, ...
Erythropoietin (EPO), originally identified for its critical hormonal role in promoting erythrocyte survival and differentiation, is a member of the large and diverse cytokine superfamily. Recent...
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Erbayraktar, Serhat, Grasso, Giovanni, Sfacteria, Alessandra, Xie, Qiao-wen, Coleman, Thomas, Kreilgaard, Mads, ...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects...
Laragione, Teresa, Bonetto, Valentina, Casoni, Filippo, Massignan, Tania, Bianchi, Giancarlo, Gianazza, Elisabetta, ...
Thiols affect a variety of cell functions, an effect known as redox regulation. We show here that treatment (1–2 h) of cells with 0.1–5 mM N-acetyl-l-cysteine (NAC) increases surface protein...
Erythropoietin both protects from and reverses experimental diabetic neuropathy
Bianchi, Roberto, Buyukakilli, Belgin, Brines, Michael, Savino, Costanza, Cavaletti, Guido, Oggioni, Norberto, ...
Erythropoietin (EPO) possesses generalized neuroprotective and neurotrophic actions. We tested the efficacy of recombinant human EPO (rhEPO) in preventing and reversing nerve dysfunction in...
Bertini, Riccardo, Allegretti, Marcello, Bizzarri, Cinzia, Moriconi, Alessio, Locati, Massimo, Zampella, Giuseppe, ...
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique...
Brines, Michael, Grasso, Giovanni, Fiordaliso, Fabio, Sfacteria, Alessandra, Ghezzi, Pietro, Fratelli, Maddalena, ...
The cytokine erythropoietin (Epo) is tissue-protective in preclinical models of ischemic, traumatic, toxic, and inflammatory injuries. We have recently characterized Epo derivatives that do not bind...
Fiordaliso, Fabio, Chimenti, Stefano, Staszewsky, Lidia, Bai, Antonio, Carlo, Eleonora, Cuccovillo, Ivan, ...
The cytokine erythropoietin (EPO) protects the heart from ischemic injury, in part by preventing apoptosis. However, EPO administration can also raise the hemoglobin concentration, which, by...
Gene expression profiling reveals a signaling role of glutathione in redox regulation
Fratelli, Maddalena, Goodwin, Leslie O., Ørom, Ulf Andersson, Lombardi, Sarah, Tonelli, Rossella, Mengozzi, Manuela, ...
Proteins can form reversible mixed disulfides with glutathione (GSH). It has been hypothesized that protein glutathionylation may represent a mechanism of redox regulation, in a fashion similar to...
Coleman, Thomas R., Westenfelder, Christof, Tögel, Florian E., Yang, Ying, Hu, Zhuma, Swenson, LeAnne, ...
Recombinant human erythropoietin (rhEPO) is receiving increasing attention as a potential therapy for prevention of injury and restoration of function in nonhematopoietic tissues. However, the...
Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
Mennini, Tiziana, De Paola, Massimiliano, Bigini, Paolo, Mastrotto, Cristina, Fumagalli, Elena, Barbera, Sara, ...
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the...
Benigni, Fabio, Sacco, Silvano, Aloe, Luigi, Ghezzi, Pietro
Fas is a receptor of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily that mediates apoptosis and some inflammatory changes. As the central administration of TNF is...
Villa, Pia, Triulzi, Sara, Cavalieri, Barbara, Di Bitondo, Rosa, Bertini, Riccardo, Barbera, Sara, ...
Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We previously reported that reparixin, a CXCL8 receptor blocker that inhibits neutrophil infiltration, and related...
Villa, Pia, Bigini, Paolo, Mennini, Tiziana, Agnello, Davide, Laragione, Teresa, Cagnotto, Alfredo, ...
Ischemic brain injury resulting from stroke arises from primary neuronal losses and by inflammatory responses. Previous studies suggest that erythropoietin (EPO) attenuates both processes. Although...
Bertini, Riccardo, Zack Howard, O.M., Dong, Hui-Fang, Oppenheim, Joost J., Bizzarri, Cinzia, Sergi, Rita, ...
Thioredoxin (Trx) is a ubiquitous intracellular protein disulfide oxidoreductase with a CXXC active site that can be released by various cell types upon activation. We show here that Trx is...
Fantuzzi, Giamila, Ghezzi, Pietro
Glucocorticoids are potent inhibitors of inflammation and endotoxic shock. This probably occurs through an inhibition of the synthesis of pro-inflammatory cytokines as well as of many of their toxic...
Taoufik, Era, Petit, Edwige, Divoux, Didier, Tseveleki, Vivian, Mengozzi, Manuela, Roberts, Michael L., ...
CNS neurons use robust cytoprotective mechanisms to ensure survival and functioning under conditions of injury. These involve pathways induced by endogenous neuroprotective cytokines such as...
Mengozzi, Manuela, Cervellini, Ilaria, Bigini, Paolo, Martone, Sara, Biondi, Antonella, Pedotti, Rosetta, ...
Erythropoietin (EPO) is of great interest as a therapy for many of the central nervous system (CNS) diseases and its administration is protective in experimental autoimmune encephalomyelitis (EAE),...