Modeling Cancer Progression via Pathway Dependencies (2008)
Elena J. Edelman, Justin Guinney, Jen-Tsan Chi, Phillip G. Febbo, Sayan Mukherjee
Cancer is a heterogeneous disease often requiring a complexity of alterations to drive a normal cell to a malignancy and ultimately to a metastatic state. Certain genetic perturbations have been...
Febbo, Phillip G, Mulligan, Mike G, Slonina, David A, Stegmaier, Kimberly, Di Vizio, Dolores, Martinez, Paul R, ...
Abstract Background The biomedical literature is a rich source of associative information but too vast for complete manual review. We have developed an automated method of literature interrogation...
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
Majumder, Pradip K., Yeh, Jen Jen, George, Daniel J., Febbo, Phillip G., Kum, Jennifer, Xue, Qi, ...
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT...
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
Wang, Jing, Iwasaki, Hiromi, Krivtsov, Andrei, Febbo, Phillip G, Thorner, Aaron R, Ernst, Patricia, ...
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional...
Defining Aggressive Prostate Cancer Using a 12-Gene Model1
Bismar, Tarek A, Demichelis, Francesca, Riva, Alberto, Kim, Robert, Varambally, Sooryanarayana, He, Le, ...
The critical clinical question in prostate cancer research is: How do we develop means of distinguishing aggressive disease from indolent disease? Using a combination of proteomic and expression...
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
Majumder, Pradip K., Yeh, Jen Jen, George, Daniel J., Febbo, Phillip G., Kum, Jennifer, Xue, Qi, ...
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT...
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease
Wang, Jing, Iwasaki, Hiromi, Krivtsov, Andrei, Febbo, Phillip G, Thorner, Aaron R, Ernst, Patricia, ...
Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners typify acute leukemias of infancy as well as therapy-related leukemias. We utilized a conditional...
Defining Aggressive Prostate Cancer Using a 12-Gene Model1
Bismar, Tarek A, Demichelis, Francesca, Riva, Alberto, Kim, Robert, Varambally, Sooryanarayana, He, Le, ...
The critical clinical question in prostate cancer research is: How do we develop means of distinguishing aggressive disease from indolent disease? Using a combination of proteomic and expression...
Febbo, Phillip G, Mulligan, Mike G, Slonina, David A, Stegmeir, Kimberly, Di Vizio, Dolores, Martinez, Paul R, ...
Stromally Expressed c-Jun Regulates Proliferation of Prostate Epithelial Cells
Li, Wenhua, Wu, Chin-Lee, Febbo, Phillip G., Olumi, Aria F.
Stromal-epithelial interactions play a critical role in development of benign prostatic hyperplasia. We have previously shown that stromal cells associated with prostatic carcinoma can potentiate...
Modeling Cancer Progression via Pathway Dependencies
Edelman, Elena J, Guinney, Justin, Chi, Jen-Tsan, Febbo, Phillip G, Mukherjee, Sayan
Cancer is a heterogeneous disease often requiring a complexity of alterations to drive a normal cell to a malignancy and ultimately to a metastatic state. Certain genetic perturbations have been...
Oltean, Sebastian, Febbo, Phillip G., Garcia-Blanco, Mariano A.
Using alternative splicing reporters we have previously observed mesenchymal epithelial transitions in Dunning AT3 rat prostate tumors. We demonstrate here that the Dunning DT and AT3 cells, which...