Philippe BULET

Characterization of a defensin from the oyster Crassostrea gigas - Recombinant production, folding, solution structure, antimicrobial activities, and gene expression (2006)

GUEGUEN, Yannick, HERPIN, Amaury, AUMELAS, André, GARNIER, Julien, FIEVET, Julie, ESCOUBAS, Jean-Michel, ...

In invertebrates, defensins were found in arthropods and in the mussels. Here, we report for the first time the identification and characterization of a defensin (Cg-Def) from an oyster. Cg-def mRNA...

PenBase, the shrimp antimicrobial peptide penaeidin database: Sequence-based classification and recommended nomenclature (2006)

GUEGUEN, Yannick, GARNIER, Julien, ROBERT, Lorenne, LEFRANC, Marie-Paule, MOUGENOT, Isabelle, DE LORGERIL, Julien, ...

Antimicrobial peptides play a major role in innate immunity. The penaeidins, initially characterized from the shrimp Litopenaeus vannamei, are a family of antimicrobial peptides that appear to be...

Penaeidins, antimicrobial peptides with chitin-binding activity, are produced and stored in shrimp granulocytes and released after microbial challenge (2000)

DESTOUMIEUX, Delphine, MUNOZ, Marcello, COSSEAU, Céline, RODRIGUEZ, Jenny, BULET, Philippe, COMPS, Marie-Annick, ...

Penaeidins are members of a new family of antimicrobial peptides isolated from a crustacean, which present both Gram-positive antibacterial and antifungal activities. We have studied the localization...

Differential display of peptides induced during the immune response of Drosophila: A matrix-assisted laser desorption ionization time-of-flight mass spectrometry study

Uttenweiler-Joseph, Sandrine, Moniatte, Marc, Lagueux, Marie, Van Dorsselaer, Alain, Hoffmann, Jules A., Bulet, Philippe

We have developed an approach based on a differential mass spectrometric analysis to detect molecules induced during the immune response of Drosophila, regardless of their biological activities. For...

Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae

Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George

A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...

Antiviral and antitumor peptides from insects

Chernysh, Sergey, Kim, S. I., Bekker, G., Pleskach, V. A., Filatova, N. A., Anikin, V. B., ...

Insects can rapidly clear microbial infections by producing a variety of immune-induced molecules including antibacterial and/or antifungal peptides/polypeptides. In this report, we present the...

Characterization of a Defensin from the Sand Fly Phlebotomus duboscqi Induced by Challenge with Bacteria or the Protozoan Parasite Leishmania major

Boulanger, Nathalie, Lowenberger, Carl, Volf, Petr, Ursic, Raul, Sigutova, Lucie, Sabatier, Laurence, ...

Antimicrobial peptides are major components of the innate immune response of epithelial cells. In insect vectors, these peptides may play a role in the control of gut pathogens. We have analyzed...

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila

Ligoxygakis, Petros, Bulet, Philippe, Reichhart, Jean-Marc

Essential aspects of innate immune responses to microbial infections appear to be conserved between insects and mammals. In particular, in both groups, transmembrane receptors of the Toll superfamily...

Differential display of peptides induced during the immune response of Drosophila: A matrix-assisted laser desorption ionization time-of-flight mass spectrometry study

Uttenweiler-Joseph, Sandrine, Moniatte, Marc, Lagueux, Marie, Van Dorsselaer, Alain, Hoffmann, Jules A., Bulet, Philippe

We have developed an approach based on a differential mass spectrometric analysis to detect molecules induced during the immune response of Drosophila, regardless of their biological activities. For...

Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae

Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George

A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...

Antiviral and antitumor peptides from insects

Chernysh, Sergey, Kim, S. I., Bekker, G., Pleskach, V. A., Filatova, N. A., Anikin, V. B., ...

Insects can rapidly clear microbial infections by producing a variety of immune-induced molecules including antibacterial and/or antifungal peptides/polypeptides. In this report, we present the...

Characterization of a Defensin from the Sand Fly Phlebotomus duboscqi Induced by Challenge with Bacteria or the Protozoan Parasite Leishmania major

Boulanger, Nathalie, Lowenberger, Carl, Volf, Petr, Ursic, Raul, Sigutova, Lucie, Sabatier, Laurence, ...

Antimicrobial peptides are major components of the innate immune response of epithelial cells. In insect vectors, these peptides may play a role in the control of gut pathogens. We have analyzed...

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila

Ligoxygakis, Petros, Bulet, Philippe, Reichhart, Jean-Marc

Essential aspects of innate immune responses to microbial infections appear to be conserved between insects and mammals. In particular, in both groups, transmembrane receptors of the Toll superfamily...

Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI

Gonzalez, Marcelo, Gueguen, Yannick, Destoumieux-Garzón, Delphine, Romestand, Bernard, Fievet, Julie, Pugnière, Martine, ...

A cDNA sequence with homologies to members of the LPS-binding protein and bactericidal/permeability-increasing protein (BPI) family was identified in the oyster Crassostrea gigas. The recombinant...

Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger

Da Silva, Pedro, Jouvensal, Laurence, Lamberty, Mireille, Bulet, Philippe, Caille, Anita, Vovelle, Françoise

The solution structure of termicin from hemocytes of the termite Pseudacanthotermes spiniger was determined by proton two-dimensional nuclear magnetic resonance spectroscopy and molecular modeling...