Rosenstiel, Philip, Huse, Klaus, Franke, Andre, Hampe, Jochen, Reichwald, Kathrin, Platzer, Cornelia, ...
Abstract Background NOD2 is an innate immune receptor for the bacterial cell wall component muramyl-dipeptide. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired...
Role of NOD2/CARD15in coronary heart disease (2007)
El Mokhtari, Nour Eddine, Ott, Stephan J, Nebel, Almut, Schäfer, Arne, Rosenstiel, Philip, Förster, Matti, ...
Abstract Background: Bacterial DNA has been repeatedly detected in atheromatous lesions of coronary heart disease (CHD) patients. Phylogenetic signatures in the atheroma lesions that are similar to...
Phylogenetically widespread alternative splicing at unusual GYNGYN donors (2006)
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Abstract Background Splice donor sites have a highly conserved GT or GC dinucleotide and an extended intronic consensus sequence GTRAGT that reflects the sequence complementarity to the U1 snRNA....
Analysis of NOD2-mediated Proteome Response to Muramyl Dipeptide in HEK293 Cells (2006)
Weichart, Dieter, Gobom, Johan, Klopfleisch, Sina, Häsler, Robert, Gustavsson, Niklas, Billmann, Susanne, ...
NOD2, a cytosolic receptor for the bacterial proteoglycan fragment muramyl dipeptide (MDP), plays an important role in the recognition of intracellular pathogens. Variants in the bacterial sensor...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays (2005)
Costello, Christine M., Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H., Hahn, Andreas, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll,Monika, Corneliussen,Brit, Costello,Christine M., Waetzig,Georg H., Mellgard,Bjorn, Koch,W. Andreas, ...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll, Monika, Corneliussen, Brit, Costello, Christine M., Waetzig, Georg H., Mellgard, Bjorn, Koch, W. Andreas, ...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Phylogenetically widespread alternative splicing at unusual GYNGYN donors
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Computational and experimental evidence is given for alternative splicing at the unusual GYNGYN motif in several species, enabling in most cases subtle protein variations.
TassDB: a database of alternative tandem splice sites
Hiller, Michael, Nikolajewa, Swetlana, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schuster, Stefan, ...
Subtle alternative splice events at tandem splice sites are frequent in eukaryotes and substantially increase the complexity of transcriptomes and proteomes. We have developed a relational database,...
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, ...
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these...
Rosenstiel, Philip, Huse, Klaus, Franke, Andre, Hampe, Jochen, Reichwald, Kathrin, Platzer, Cornelia, ...
Role of NOD2/CARD15 in coronary heart disease
El Mokhtari, Nour Eddine, Ott, Stephan J, Nebel, Almut, Schäfer, Arne, Rosenstiel, Philip, Förster, Matti, ...
Raelson, John V., Little, Randall D., Ruether, Andreas, Fournier, Hélène, Paquin, Bruno, Van Eerdewegh, Paul, ...
Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases. Here we report the results of a GWA study for...
Lucius, Ralph, Gallinat, Stefan, Rosenstiel, Philip, Herdegen, Thomas, Sievers, Jobst, Unger, Thomas
The renin-angiotensin system (RAS) has been traditionally linked to blood pressure and volume regulation mediated through the angiotensin II (ANG II) type 1 (AT1) receptor. Here we report that ANG II...
Assessing the fraction of short-distance tandem splice sites under purifying selection
Hiller, Michael, Szafranski, Karol, Sinha, Rileen, Huse, Klaus, Nikolajewa, Swetlana, Rosenstiel, Philip, ...
Many alternative splice events result in subtle mRNA changes, and most of them occur at short-distance tandem donor and acceptor sites. The splicing mechanism of such tandem sites likely involves the...