Peter van der Geer

RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization

Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...

Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...

Phorbol 12-Myristate 13-Acetate-Induced Release of the Colony-Stimulating Factor 1 Receptor Cytoplasmic Domain into the Cytosol Involves Two Separate Cleavage Events

Wilhelmsen, Kevin, Van Der Geer, Peter

The colony-stimulating factor 1 (CSF-1) receptor is a protein-tyrosine kinase that regulates cell division, differentiation, and development. In response to phorbol 12-myristate 13-acetate (PMA), the...

RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization

Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...

Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...

Phorbol 12-Myristate 13-Acetate-Induced Release of the Colony-Stimulating Factor 1 Receptor Cytoplasmic Domain into the Cytosol Involves Two Separate Cleavage Events

Wilhelmsen, Kevin, Van Der Geer, Peter

The colony-stimulating factor 1 (CSF-1) receptor is a protein-tyrosine kinase that regulates cell division, differentiation, and development. In response to phorbol 12-myristate 13-acetate (PMA), the...

MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity

Wiley, Sandra E., Murphy, Anne N., Ross, Stuart A., Van Der Geer, Peter, Dixon, Jack E.

Members of the thiazolidinedione (TZD) class of insulin-sensitizing drugs are extensively used in the treatment of type 2 diabetes. Pioglitazone, a member of the TZD family, has been shown to bind...

Role of P120 Ras-Gap in Directed Cell Movement

Kulkarni, Sarang V., Gish, Gerald, Van Der Geer, Peter, Henkemeyer, Mark, Pawson, Tony

We have used cell lines deficient in p120 Ras GTPase activating protein (Ras-GAP) to investigate the roles of Ras-GAP and the associated p190 Rho-GAP (p190) in cell polarity and cell migration. Cell...