Die Überexpression von P-Glykoprotein (Pgp) ist mit einem schlechten Therapieergebnis bei Kindern mit akuter myeloischer Leukämie (AML) korreliert. Die Ergebnisse dieser Arbeit zeigen, dass die...
Jarret, Caroline, Stauffer, Frédéric, Henz, Matthias E, Marty, Maurus, Lüönd, Rainer M, Bobálová, Janette, ...
Background: Porphobilinogen synthase is the second enzyme involved in the biosynthesis of natural tetrapyrrolic compounds, and condenses two molecules of 5-aminolevulinic acid (ALA) through a...
Jarret, Caroline, Stauffer, Frédéric, Henz, Matthias E, Marty, Maurus, Lüönd, Rainer M, Bobálová, Janette, ...
Background: Porphobilinogen synthase is the second enzyme involved in the biosynthesis of natural tetrapyrrolic compounds, and condenses two molecules of 5-aminolevulinic acid (ALA) through a...
Genome-wide association study identifies novel breast cancer susceptibility loci (2007)
Easton, Douglas F., Pooley, Karen A., Dunning, Alison M., Pharoah, Paul D.P., Thompson, Deborah, Ballinger, Dennis G., ...
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast...
Characterization of Ferredoxin:Thioredoxin Reductase Modified by Site-directed Mutagenesis (2007)
Glauser, Dominique A., Bourquin, Florence, Manieri, Wanda, Schürmann, Peter
Ferredoxin:thioredoxin reductase (FTR) is a key regulatory enzyme of oxygenic photosynthetic cells involved in the reductive regulation of important target enzymes. It catalyzes the two-electron...
Characterization of Ferredoxin:Thioredoxin Reductase Modified by Site-directed Mutagenesis (2007)
Glauser, Dominique A., Bourquin, Florence, Manieri, Wanda, Schürmann, Peter
Ferredoxin:thioredoxin reductase (FTR) is a key regulatory enzyme of oxygenic photosynthetic cells involved in the reductive regulation of important target enzymes. It catalyzes the two-electron...
Crystal structures of two functionally different thioredoxins in spinach chloroplasts (2007)
Capitani, Guido, Markovi-Housley, Zora, Del Val, Gregorio, Morris, May, Jansonius, Johan N., Schürmann, Peter
Thioredoxins are small ubiquitous proteins which act as general protein disulfide reductases in living cells. Chloroplasts contain two distinct thioredoxins (•f and m) with different phylogenetic...
Kinetics and Thioredoxin Specificity of Thiol Modulation of the Chloroplast H+-ATPase (2007)
Schwarz, Oliver, Schürmann, Peter, Strotmann, Heinrich
The kinetics of thiol modulation of the chloroplast H+-ATPase (CF0CF1) in membrana were analyzed by employing thioredoxins that were kept reduced by 0.1 mM dithiothreitol. The kinetics of thiol...
Activation of the Potato Tuber ADP-glucose Pyrophosphorylase by Thioredoxin (2007)
Ballicora, Miguel A., Frueauf, Jeremiah B., Fu, Yingbin, Schürmann, Peter, Preiss, Jack
The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase (ADP-GlcPPase) catalyzes the first committed step in starch biosynthesis. The main type of regulation of this enzyme is...
Suter, Marianne, Von Ballmoos, Peter, Kopriva, Stanislav, Op Den Camp, Roel, Schaller, Johann, Kuhlemeier, Cris, ...
Adenosine 5'-phosphosulfate (APS) sulfotransferase and APS reductase have been described as key enzymes of assimilatory sulfate reduction of plants catalyzing the reduction of APS to bound and free...
Crystal structures of two functionally different thioredoxins in spinach chloroplasts (2007)
Capitani, Guido, Markovi-Housley, Zora, Del Val, Gregorio, Morris, May, Jansonius, Johan N., Schürmann, Peter
Thioredoxins are small ubiquitous proteins which act as general protein disulfide reductases in living cells. Chloroplasts contain two distinct thioredoxins (•f and m) with different phylogenetic...
Kinetics and Thioredoxin Specificity of Thiol Modulation of the Chloroplast H+-ATPase (2007)
Schwarz, Oliver, Schürmann, Peter, Strotmann, Heinrich
The kinetics of thiol modulation of the chloroplast H+-ATPase (CF0CF1) in membrana were analyzed by employing thioredoxins that were kept reduced by 0.1 mM dithiothreitol. The kinetics of thiol...
Activation of the Potato Tuber ADP-glucose Pyrophosphorylase by Thioredoxin (2007)
Ballicora, Miguel A., Frueauf, Jeremiah B., Fu, Yingbin, Schürmann, Peter, Preiss, Jack
The potato tuber (Solanum tuberosum L.) ADP-glucose pyrophosphorylase (ADP-GlcPPase) catalyzes the first committed step in starch biosynthesis. The main type of regulation of this enzyme is...
Suter, Marianne, Von Ballmoos, Peter, Kopriva, Stanislav, Op Den Camp, Roel, Schaller, Johann, Kuhlemeier, Cris, ...
Adenosine 5'-phosphosulfate (APS) sulfotransferase and APS reductase have been described as key enzymes of assimilatory sulfate reduction of plants catalyzing the reduction of APS to bound and free...
Plant Adenosine 5'-Phosphosulfate Reductase Is a Novel Iron-Sulfur Protein (2007)
Kopriva, Stanislav, Büchert, Thomas, Fritz, Günter, Suter, Marianne, Weber, Markus, Benda, Rüdiger, ...
Adenosine 5'-phosphosulfate reductase (APR) catalyzes the two-electron reduction of adenosine 5'-phosphosulfate to sulfite and AMP, which represents the key step of sulfate assimilation in higher...
Plant Adenosine 5'-Phosphosulfate Reductase Is a Novel Iron-Sulfur Protein (2007)
Kopriva, Stanislav, Büchert, Thomas, Fritz, Günter, Suter, Marianne, Weber, Markus, Benda, Rüdiger, ...
Adenosine 5'-phosphosulfate reductase (APR) catalyzes the two-electron reduction of adenosine 5'-phosphosulfate to sulfite and AMP, which represents the key step of sulfate assimilation in higher...
Kopriva, Stanislav, Büchert, Thomas, Fritz, Günter, Suter, Marianne, Benda, Rüdiger, Schünemann, Volker, ...
It was generally accepted that plants, algae, and phototrophic bacteria use adenosine 5'-phosphosulfate (APS) for assimilatory sulfate reduction, whereas bacteria and fungi use phosphoadenosine...
Kopriva, Stanislav, Büchert, Thomas, Fritz, Günter, Suter, Marianne, Benda, Rüdiger, Schünemann, Volker, ...
It was generally accepted that plants, algae, and phototrophic bacteria use adenosine 5'-phosphosulfate (APS) for assimilatory sulfate reduction, whereas bacteria and fungi use phosphoadenosine...
Mikkelsen, René, Mutenda, Kudzai E., Mant, Alexandra, Schürmann, Peter, Blennow, Andreas
The recently discovered potato tuber (Solanum tuberosum) -glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in which...
Mikkelsen, René, Mutenda, Kudzai E., Mant, Alexandra, Schürmann, Peter, Blennow, Andreas
The recently discovered potato tuber (Solanum tuberosum) -glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in which...
A complete ferredoxin/thioredoxin system regulates fundamental processes in amyloplasts (2007)
Balmer, Yves, Vensel, William H., Cai, Nick, Manieri, Wanda, Schürmann, Peter, Hurkman, William J., ...
A growing number of processes throughout biology are regulated by redox via thiol–disulfide exchange. This mechanism is particularly widespread in plants, where almost 200 proteins have been linked...
A complete ferredoxin/thioredoxin system regulates fundamental processes in amyloplasts (2007)
Balmer, Yves, Vensel, William H., Cai, Nick, Manieri, Wanda, Schürmann, Peter, Hurkman, William J., ...
A growing number of processes throughout biology are regulated by redox via thiol–disulfide exchange. This mechanism is particularly widespread in plants, where almost 200 proteins have been linked...
Gaymard, Eric, Franchini, Laurence, Manieri, Wanda, Stutz, Erhard, Schürmann, Peter
Ferredoxin:thioredoxin reductase (FTR) is a heterodimeric Fe---S containing disulfide reductase involved in the light-dependent activation of photosynthetic enzymes. We have designed a dicistronic...
König, Janine, Baier, Margarete, Horling, Frank, Kahmann, Uwe, Harris, Gary, Schürmann, Peter, ...
The 2-cysteine peroxiredoxins (2-Cys Prx) constitute an ancient family of peroxide detoxifying enzymes and have acquired a plant-specific function in the oxygenic environment of the chloroplast....
Gaymard, Eric, Franchini, Laurence, Manieri, Wanda, Stutz, Erhard, Schürmann, Peter
Ferredoxin:thioredoxin reductase (FTR) is a heterodimeric Fe---S containing disulfide reductase involved in the light-dependent activation of photosynthetic enzymes. We have designed a dicistronic...
König, Janine, Baier, Margarete, Horling, Frank, Kahmann, Uwe, Harris, Gary, Schürmann, Peter, ...
The 2-cysteine peroxiredoxins (2-Cys Prx) constitute an ancient family of peroxide detoxifying enzymes and have acquired a plant-specific function in the oxygenic environment of the chloroplast....
Proteomics gives insight into the regulatory function of chloroplast thioredoxins (2007)
Balmer, Yves, Koller, Antonius, Del Val, Gregorio, Manieri, Wanda, Schürmann, Peter, Buchanan, Bob B.
Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play...
Proteomics gives insight into the regulatory function of chloroplast thioredoxins (2007)
Balmer, Yves, Koller, Antonius, Del Val, Gregorio, Manieri, Wanda, Schürmann, Peter, Buchanan, Bob B.
Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play...
Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria (2007)
Balmer, Yves, Vensel, William H., Tanaka, Charlene K., Hurkman, William J., Gelhaye, Eric, Rouhier, Nicolas, ...
Mitochondria contain thioredoxin (Trx), a regulatory disulfide protein, and an associated flavoenzyme, NADP/Trx reductase, which provide a link to NADPH in the organelle. Unlike animal and yeast...
Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria (2007)
Balmer, Yves, Vensel, William H., Tanaka, Charlene K., Hurkman, William J., Gelhaye, Eric, Rouhier, Nicolas, ...
Mitochondria contain thioredoxin (Trx), a regulatory disulfide protein, and an associated flavoenzyme, NADP/Trx reductase, which provide a link to NADPH in the organelle. Unlike animal and yeast...
Balmer, Yves, Schürmann, Peter
Chloroplast fructose 1,6-bisphosphatase (FBPase) is activated by reduction of a regulatory disulfide through thioredoxin f (Trx f). In the course of this reduction a transient mixed disulfide is...
Balmer, Yves, Schürmann, Peter
Chloroplast fructose 1,6-bisphosphatase (FBPase) is activated by reduction of a regulatory disulfide through thioredoxin f (Trx f). In the course of this reduction a transient mixed disulfide is...
Xu, Xingfu, Kim, Sung-Kun, Schürmann, Peter, Hirasawa, Masakazu, Tripathy, Jatindra N., Smith, Jody, ...
The reduction of ferredoxin–thioredoxin reductase (FTR) by plant-type ferredoxin plays an important role in redox regulation in plants and cyanobacteria. Nuclear magnetic resonance (NMR) was used...
Xu, Xingfu, Kim, Sung-Kun, Schürmann, Peter, Hirasawa, Masakazu, Tripathy, Jatindra N., Smith, Jody, ...
The reduction of ferredoxin–thioredoxin reductase (FTR) by plant-type ferredoxin plays an important role in redox regulation in plants and cyanobacteria. Nuclear magnetic resonance (NMR) was used...
Del Val, Gregorio, Maurer, Fabienne, Stutz, Erhard, Schürmann, Peter
Spinach chloroplast thioredoxin f
Del Val, Gregorio, Maurer, Fabienne, Stutz, Erhard, Schürmann, Peter
Spinach chloroplast thioredoxin f
Proteomics Uncovers Proteins Interacting Electrostatically with Thioredoxin in Chloroplasts (2007)
Balmer, Yves, Koller, Antonius, Del Val, Greg, Schürmann, Peter, Buchanan, Bob B.
The ability of thioredoxin f to form an electrostatic (non-covalent) complex, earlier found with fructose-1,6-bisphosphatase, was extended to include 27 previously unrecognized proteins functional in...
Proteomics Uncovers Proteins Interacting Electrostatically with Thioredoxin in Chloroplasts (2007)
Balmer, Yves, Koller, Antonius, Del Val, Greg, Schürmann, Peter, Buchanan, Bob B.
The ability of thioredoxin f to form an electrostatic (non-covalent) complex, earlier found with fructose-1,6-bisphosphatase, was extended to include 27 previously unrecognized proteins functional in...
Miller, Marie, Schürmann, Peter, Hodges, Michael, Jacquot, Jean-Pierre
Like many other soluble chloroplastic enzymes, thioredoxin f is nuclear-encoded and expressed as a precursor protein. After synthesis in the cytosol, it is imported into the chloroplast with...
Miller, Marie, Schürmann, Peter, Hodges, Michael, Jacquot, Jean-Pierre
Like many other soluble chloroplastic enzymes, thioredoxin f is nuclear-encoded and expressed as a precursor protein. After synthesis in the cytosol, it is imported into the chloroplast with...
On the Quaternary Assembly of Spinach Chloroplast Thioredoxin m (2007)
Capitani, Guido, Schürmann, Peter
Thioredoxin m from spinach chloroplast has been structurally characterized both by X-ray crystallography and by NMR. Thioredoxin m is known to be monomeric, a finding which is confirmed by the NMR...
On the Quaternary Assembly of Spinach Chloroplast Thioredoxin m (2007)
Capitani, Guido, Schürmann, Peter
Thioredoxin m from spinach chloroplast has been structurally characterized both by X-ray crystallography and by NMR. Thioredoxin m is known to be monomeric, a finding which is confirmed by the NMR...
Reduction of ferredoxin : thioredoxin reductase by artificial electron donors (2007)
Schürmann, Peter, Stritt-Etter, Anne Lise, Li, Junsheng
The ferredoxin:thioredoxin reductase is an essential enzyme of the light dependent regulatory system in oxygenic photosynthesis. It is composed of two dissimilar subunits and contains a 4Fe-4S...
Reduction of ferredoxin : thioredoxin reductase by artificial electron donors (2007)
Schürmann, Peter, Stritt-Etter, Anne Lise, Li, Junsheng
The ferredoxin:thioredoxin reductase is an essential enzyme of the light dependent regulatory system in oxygenic photosynthesis. It is composed of two dissimilar subunits and contains a 4Fe-4S...
Manieri, W., Franchini, L., Raeber, L., Dai, Shaodong, Stritt-Etter, Anne-Lise, Schürmann, Peter
The variable subunit of spinach ferredoxin:thioredoxin reductase (FTR) has an extended N-terminus compared to FTRs from other sources and this was proposed to contribute to the instability of the...
Manieri, W., Franchini, L., Raeber, L., Dai, Shaodong, Stritt-Etter, Anne-Lise, Schürmann, Peter
The variable subunit of spinach ferredoxin:thioredoxin reductase (FTR) has an extended N-terminus compared to FTRs from other sources and this was proposed to contribute to the instability of the...
Zhang, Ning, Portis Jr., Archie R., Schürmann, Peter
Arabidopsis Rubisco activase was recently shown to be regulated by redox changes in the larger (46-kDa) isoform specifically mediated by thioredoxin-f [Zhang and Portis (1999) Proc Natl Acad Sci USA...
Zhang, Ning, Portis Jr., Archie R., Schürmann, Peter
Arabidopsis Rubisco activase was recently shown to be regulated by redox changes in the larger (46-kDa) isoform specifically mediated by thioredoxin-f [Zhang and Portis (1999) Proc Natl Acad Sci USA...
Dai, Shaodong, Johansson, Kenth, Miginiac-Maslow, Myroslawa, Schürmann, Peter, Eklund, Hans
The role of the ferredoxin:thioredoxin system in the reversible light activation of chloroplast enzymes by thiol-disulfide interchange with thioredoxins is now well established. Recent fruitful...
Dai, Shaodong, Johansson, Kenth, Miginiac-Maslow, Myroslawa, Schürmann, Peter, Eklund, Hans
The role of the ferredoxin:thioredoxin system in the reversible light activation of chloroplast enzymes by thiol-disulfide interchange with thioredoxins is now well established. Recent fruitful...
Plant Thioredoxin Systems Revisited (2006)
Thioredoxins, the ubiquitous small proteins with a redox active disulfide bridge, are important regulatory elements in plant metabolism. Initially recognized as regulatory proteins in the reversible...
Plant Thioredoxin Systems Revisited (2006)
Thioredoxins, the ubiquitous small proteins with a redox active disulfide bridge, are important regulatory elements in plant metabolism. Initially recognized as regulatory proteins in the reversible...
Dai, Shaodong, Schwendtmayer, Cristina, Johansson, Kenth, Ramaswamy, S, Schürmann, Peter, Eklund, Hans
A pre-requisite for life on earth is the conversion of solar energy into chemical energy by photosynthetic organisms. Plants and photosynthetic oxygenic microorganisms trap the energy from sunlight...
Dai, Shaodong, Schwendtmayer, Cristina, Johansson, Kenth, Ramaswamy, S, Schürmann, Peter, Eklund, Hans
A pre-requisite for life on earth is the conversion of solar energy into chemical energy by photosynthetic organisms. Plants and photosynthetic oxygenic microorganisms trap the energy from sunlight...
Mikkelsen, René, Mutenda, Kudzai E., Mant, Alexandra, Schürmann, Peter, Blennow, Andreas
The recently discovered potato tuber (Solanum tuberosum) {alpha}-glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in...
Brandschutz : Zusammenfassung von Seminaren SS 1999 - SS 2002 (2002)
Düh, Gerhard, Schürmann, Peter, Szyszkowitz-Kowalski, Karla, Schaller, Till, Sternagel, Thomas, Volpp, Henning
Man würde eine Tatsache leugnen, wenn man behauptet, daß die brandschutztechnischen Anforderungen in den Gesetzen und Verordnungen die Architektur nicht wesentlich beeinflussen würden. Bei...
Brandschutz : Zusammenfassung von Seminaren SS 1999 - SS 2002 (2002)
Düh, Gerhard, Schürmann, Peter, Szyszkowitz-Kowalski, Karla, Schaller, Till, Sternagel, Thomas, Volpp, Henning
Man würde eine Tatsache leugnen, wenn man behauptet, daß die brandschutztechnischen Anforderungen in den Gesetzen und Verordnungen die Architektur nicht wesentlich beeinflussen würden. Bei...
König, Janine, Baier, Margarete, Horling, Frank, Kahmann, Uwe, Harris, Gary, Schürmann, Peter, ...
The 2-cysteine peroxiredoxins (2-Cys Prx) constitute an ancient family of peroxide detoxifying enzymes and have acquired a plant-specific function in the oxygenic environment of the chloroplast....
Proteomics gives insight into the regulatory function of chloroplast thioredoxins
Balmer, Yves, Koller, Antonius, Del Val, Gregorio, Manieri, Wanda, Schürmann, Peter, Buchanan, Bob B.
Thioredoxins are small multifunctional redox active proteins widely if not universally distributed among living organisms. In chloroplasts, two types of thioredoxins (f and m) coexist and play...
Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria
Balmer, Yves, Vensel, William H., Tanaka, Charlene K., Hurkman, William J., Gelhaye, Eric, Rouhier, Nicolas, ...
Mitochondria contain thioredoxin (Trx), a regulatory disulfide protein, and an associated flavoenzyme, NADP/Trx reductase, which provide a link to NADPH in the organelle. Unlike animal and yeast...
Steinmann, Daniel, Barth, Heidi, Gissler, Bettina, Schürmann, Peter, Adah, Mohammed I., Gerlach, J. Tilman, ...
Hepatitis C virus (HCV) is a leading cause of chronic viral hepatitis worldwide. The study of antibody-mediated virus neutralization has been hampered by the lack of an efficient and high-throughput...
Effect of Powdery Mildew Infection on Photosynthesis by Leaves and Chloroplasts of Sugar Beets 1
Magyarosy, Andrew C., Schürmann, Peter, Buchanan, Bob B.
Chloroplasts isolated from powdery mildew-infected (Erysiphe polygoni DC) sugar beet leaves (Beta vulgaris L) showed a reduction in the rate of electron transport and in the accompanying ATP...
Mikkelsen, René, Mutenda, Kudzai E., Mant, Alexandra, Schürmann, Peter, Blennow, Andreas
The recently discovered potato tuber (Solanum tuberosum) α-glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in which...