Peter Philippsen

Ashbya Genome Database 3.0: a cross-species genome and transcriptome browser for yeast biologists (2007)

Gattiker, Alexandre, Rischatsch, Riccarda, Demougin, Philippe, Voegeli, Sylvia, Dietrich, Fred S, Philippsen, Peter, ...

Abstract Background The Ashbya Genome Database (AGD) 3.0 is an innovative cross-species genome and transcriptome browser based on release 40 of the Ensembl developer environment. Description AGD 3.0...

Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii (2003)

Brachat, Sophie, Dietrich, Fred S, Voegeli, Sylvia, Zhang, Zhihong, Stuart, Larissa, Lerch, Anita, ...

Abstract Background The recently sequenced genome of the filamentous fungus Ashbya gossypii revealed remarkable similarities to that of the budding yeast Saccharomyces cerevisiae both at the level of...

Time-Lapse Video Microscopy Analysis Reveals Astral Microtubule Detachment in the Yeast Spindle Pole Mutant cnm67V⃞

Hoepfner, Dominic, Brachat, Arndt, Philippsen, Peter

Saccharomyces cerevisiae cnm67Δ cells lack the spindle pole body (SPB) outer plaque, the main attachment site for astral (cytoplasmic) microtubules, leading to frequent nuclear segregation failure....

Saccharomyces cerevisiae Cells with Defective Spindle Pole Body Outer Plaques Accomplish Nuclear Migration via Half-Bridge–organized Microtubules

Brachat, Arndt, Kilmartin, John V., Wach, Achim, Philippsen, Peter

Cnm67p, a novel yeast protein, localizes to the microtubule organizing center, the spindle pole body (SPB). Deletion of CNM67 (YNL225c) frequently results in spindle misorientation and impaired...

Cnm67p Is a Spacer Protein of the Saccharomyces cerevisiae Spindle Pole Body Outer Plaque

Schaerer, Florian, Morgan, Garry, Winey, Mark, Philippsen, Peter

In Saccharomyces cerevisiae, the spindle pole body (SPB) is the functional homolog of the mammalian centrosome, responsible for the organization of the tubulin cytoskeleton. Cytoplasmic (astral)...

Reorientation of Mispositioned Spindles in Short Astral Microtubule Mutant spc72Δ Is Dependent on Spindle Pole Body Outer Plaque and Kar3 Motor ProteinV⃞

Hoepfner, Dominic, Schaerer, Florian, Brachat, Arndt, Wach, Achim, Philippsen, Peter

Nuclear migration and positioning in Saccharomyces cerevisiae depend on long astral microtubules emanating from the spindle pole bodies (SPBs). Herein, we show by in vivo fluorescence microscopy that...

A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits

Gadal, Olivier, Strauß, Daniela, Braspenning, Joris, Hoepfner, Dominic, Petfalski, Elisabeth, Philippsen, Peter, ...

Ribosomal precursor particles are assembled in the nucleolus before export into the cytoplasm. Using a visual assay for nuclear accumulation of 60S subunits, we have isolated several...

Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii

Brachat, Sophie, Dietrich, Fred S, Voegeli, Sylvia, Zhang, Zhihong, Stuart, Larissa, Lerch, Anita, ...

Although, the S. cerevisiae genome is rightly considered as one of the most accurately sequenced and annotated eukaryotic genomes, it still benefits substantially from comparison to the completed...

Maximal Polar Growth Potential Depends on the Polarisome Component AgSpa2 in the Filamentous Fungus Ashbya gossypiiV⃞

Knechtle, Philipp, Dietrich, Fred, Philippsen, Peter

We used actin staining and videomicroscopy to analyze the development from a spore to a young mycelium in the filamentous ascomycete Ashbya gossypii. The development starts with an initial isotropic...

A Ras-like GTPase Is Involved in Hyphal Growth Guidance in the Filamentous Fungus Ashbya gossypiiV⃞

Bauer, Yasmina, Knechtle, Philipp, Wendland, Jürgen, Helfer, Hanspeter, Philippsen, Peter

Characteristic features of morphogenesis in filamentous fungi are sustained polar growth at tips of hyphae and frequent initiation of novel growth sites (branches) along the extending hyphae. We have...

The Ashbya Genome Database (AGD)—a tool for the yeast community and genome biologists

Hermida, Leandro, Brachat, Sophie, Voegeli, Sylvia, Philippsen, Peter, Primig, Michael

The Ashbya Genome Database (AGD) is a comprehensive online source of information covering genes from the filamentous fungus Ashbya gossypii. The database content is based upon comparative genome...

Delta sequences in the 5' non-coding region of yeast tRNA genes

Gafner, Jürg, Robertis, Eddy M.De, Philippsen, Peter

Two so far undetected tRNA genes were found close to delta (δ) sequences at the sup4 locus on chromosome X in the genome of Saccharomyces cerevisiae. The two genes were identified from their...

From Function to Shape: A Novel Role of a Formin in Morphogenesis of the Fungus Ashbya gossypiiV⃞

Schmitz, Hans-Peter, Kaufmann, Andreas, Köhli, Michael, Laissue, Pierre Philippe, Philippsen, Peter

Morphogenesis of filamentous ascomycetes includes continuously elongating hyphae, frequently emerging lateral branches, and, under certain circumstances, symmetrically dividing hyphal tips. We...

Time-Lapse Video Microscopy Analysis Reveals Astral Microtubule Detachment in the Yeast Spindle Pole Mutant cnm67V⃞

Hoepfner, Dominic, Brachat, Arndt, Philippsen, Peter

Saccharomyces cerevisiae cnm67Δ cells lack the spindle pole body (SPB) outer plaque, the main attachment site for astral (cytoplasmic) microtubules, leading to frequent nuclear segregation failure....

Saccharomyces cerevisiae Cells with Defective Spindle Pole Body Outer Plaques Accomplish Nuclear Migration via Half-Bridge–organized Microtubules

Brachat, Arndt, Kilmartin, John V., Wach, Achim, Philippsen, Peter

Cnm67p, a novel yeast protein, localizes to the microtubule organizing center, the spindle pole body (SPB). Deletion of CNM67 (YNL225c) frequently results in spindle misorientation and impaired...

Cnm67p Is a Spacer Protein of the Saccharomyces cerevisiae Spindle Pole Body Outer Plaque

Schaerer, Florian, Morgan, Garry, Winey, Mark, Philippsen, Peter

In Saccharomyces cerevisiae, the spindle pole body (SPB) is the functional homolog of the mammalian centrosome, responsible for the organization of the tubulin cytoskeleton. Cytoplasmic (astral)...

Reorientation of Mispositioned Spindles in Short Astral Microtubule Mutant spc72Δ Is Dependent on Spindle Pole Body Outer Plaque and Kar3 Motor ProteinV⃞

Hoepfner, Dominic, Schaerer, Florian, Brachat, Arndt, Wach, Achim, Philippsen, Peter

Nuclear migration and positioning in Saccharomyces cerevisiae depend on long astral microtubules emanating from the spindle pole bodies (SPBs). Herein, we show by in vivo fluorescence microscopy that...

A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits

Gadal, Olivier, Strauß, Daniela, Braspenning, Joris, Hoepfner, Dominic, Petfalski, Elisabeth, Philippsen, Peter, ...

Ribosomal precursor particles are assembled in the nucleolus before export into the cytoplasm. Using a visual assay for nuclear accumulation of 60S subunits, we have isolated several...

Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii

Brachat, Sophie, Dietrich, Fred S, Voegeli, Sylvia, Zhang, Zhihong, Stuart, Larissa, Lerch, Anita, ...

Although, the S. cerevisiae genome is rightly considered as one of the most accurately sequenced and annotated eukaryotic genomes, it still benefits substantially from comparison to the completed...

Maximal Polar Growth Potential Depends on the Polarisome Component AgSpa2 in the Filamentous Fungus Ashbya gossypiiV⃞

Knechtle, Philipp, Dietrich, Fred, Philippsen, Peter

We used actin staining and videomicroscopy to analyze the development from a spore to a young mycelium in the filamentous ascomycete Ashbya gossypii. The development starts with an initial isotropic...

A Ras-like GTPase Is Involved in Hyphal Growth Guidance in the Filamentous Fungus Ashbya gossypiiV⃞

Bauer, Yasmina, Knechtle, Philipp, Wendland, Jürgen, Helfer, Hanspeter, Philippsen, Peter

Characteristic features of morphogenesis in filamentous fungi are sustained polar growth at tips of hyphae and frequent initiation of novel growth sites (branches) along the extending hyphae. We have...

The Ashbya Genome Database (AGD)—a tool for the yeast community and genome biologists

Hermida, Leandro, Brachat, Sophie, Voegeli, Sylvia, Philippsen, Peter, Primig, Michael

The Ashbya Genome Database (AGD) is a comprehensive online source of information covering genes from the filamentous fungus Ashbya gossypii. The database content is based upon comparative genome...

Delta sequences in the 5' non-coding region of yeast tRNA genes

Gafner, Jürg, Robertis, Eddy M.De, Philippsen, Peter

Two so far undetected tRNA genes were found close to delta (δ) sequences at the sup4 locus on chromosome X in the genome of Saccharomyces cerevisiae. The two genes were identified from their...

From Function to Shape: A Novel Role of a Formin in Morphogenesis of the Fungus Ashbya gossypiiV⃞

Schmitz, Hans-Peter, Kaufmann, Andreas, Köhli, Michael, Laissue, Pierre Philippe, Philippsen, Peter

Morphogenesis of filamentous ascomycetes includes continuously elongating hyphae, frequently emerging lateral branches, and, under certain circumstances, symmetrically dividing hyphal tips. We...

The SH3/PH Domain Protein AgBoi1/2 Collaborates with the Rho-Type GTPase AgRho3 To Prevent Nonpolar Growth at Hyphal Tips of Ashbya gossypii▿

Knechtle, Philipp, Wendland, Jürgen, Philippsen, Peter

Unlike most other cells, hyphae of filamentous fungi permanently elongate and lack nonpolar growth phases. We identified AgBoi1/2p in the filamentous ascomycete Ashbya gossypii as a component...

The Anaphase-Promoting Complex/Cyclosome Is Required for Anaphase Progression in Multinucleated Ashbya gossypii Cells▿ †

Gladfelter, Amy S., Sustreanu, Nicoleta, Hungerbuehler, A. Katrin, Voegeli, Sylvia, Galati, Virginie, Philippsen, Peter

Regulated protein degradation is essential for eukaryotic cell cycle progression. The anaphase-promoting complex/cyclosome (APC/C) is responsible for the protein destruction required for the...

Limited Functional Redundancy and Oscillation of Cyclins in Multinucleated Ashbya gossypii Fungal Cells▿ †

Hungerbuehler, A. Katrin, Philippsen, Peter, Gladfelter, Amy S.

Cyclin protein behavior has not been systematically investigated in multinucleated cells with asynchronous mitoses. Cyclins are canonical oscillating cell cycle proteins, but it is unclear how...

Asynchronous nuclear division cycles in multinucleated cells

Gladfelter, Amy S., Hungerbuehler, A. Katrin, Philippsen, Peter

Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii. Nuclear pedigree analysis and...

A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae

Hoepfner, Dominic, Van Den Berg, Marlene, Philippsen, Peter, Tabak, Henk F., Hettema, Ewald H.

In vivo time-lapse microscopy reveals that the number of peroxisomes in Saccharomyces cerevisiae cells is fairly constant and that a subset of the organelles are targeted and segregated to the bud in...