Ning Yan, Serban Nacu, Jeffrey Weber, Susan P. Holmes, Peter P. Lee
BackgroundDysfunction of the immune system has been documented in many types of cancers. The precise nature and molecular basis of immune dysfunction in the cancer state are not well defined.Methods...
Lagenaur, Laurel, Liu, Xiaowen, Simpson, David A, Essenmacher, Kirsten, Parker, Courtney, Chang, Chia-Hwa, ...
No abstract available.
Daniel S. Chen, Yoav Soen, Tor B. Stuge, Peter P. Lee, Jeffrey S. Weber, Patrick O. Brown, ...
Patients vaccinated with melanoma-associated peptides show a wide diversity of responses, analysis of which may help us understand the differing clinical responses to such vaccines.
Daniel S. Chen, Yoav Soen, Tor B. Stuge, Peter P. Lee, Jeffrey S. Weber, Patrick O. Brown, ...
Background In contrast to many animal model studies, immunotherapeutic trials in humans suffering from cancer invariably result in a broad range of outcomes, from long-lasting remissions to no...
Holbrook E. Kohrt, Navid Nouri, Kent Nowels, Denise Johnson, Susan Holmes, Peter P. Lee
Background While lymph node metastasis is among the strongest predictors of disease-free and overall survival for patients with breast cancer, the immunological nature of tumor-draining lymph nodes...
Diversity and Recognition Efficiency of T Cell Responses to Cancer (2004)
Tor B. Stuge, Susan P. Holmes, Sahdev Saharan, Andrea Tuettenberg, Mario Roederer, Jeffrey S. Weber, ...
State-of-the art analysis of patients' response to melanoma vaccines yields lessons about cancer vaccines and rationale vaccine design in general.
Diversity and Recognition Efficiency of T Cell Responses to Cancer (2004)
Tor B. Stuge, Susan P. Holmes, Sahdev Saharan, Andrea Tuettenberg, Mario Roederer, Jeffrey S. Weber, ...
Background Melanoma patients vaccinated with tumor-associated antigens frequently develop measurable peptide-specific CD8+ T cell responses; however, such responses often do not confer clinical...
UCSD School of Medicine independent study project : 1989, nos. 42-62. (1989)
Iriye, Brian K., Johnson, Joanne K., Katzman, Jeff., Keyser, Peter F., Kimura, Bruce., Guss, David., ...
Thesis (M.D.)--University of California, San Diego, 1989.
Typescript (photocopy).
Molldrem, Jeffrey J., Lee, Peter P., Kant, Shreya, Wieder, Eric, Jiang, Weidong, Lu, Sijie, ...
We have shown that cytotoxic T lymphocytes specific for PR1, an HLA-A2–restricted nonopeptide derived from proteinase 3, kill leukemia cells and may contribute to the elimination of chronic...
Chang, Theresa L.-Y., Chang, Chia-Hwa, Simpson, David A., Xu, Qiang, Martin, Patrick K., Lagenaur, Laurel A., ...
The predominant mode of HIV transmission worldwide is via heterosexual contact, with the cervico-vaginal mucosa being the main portal of entry in women. The cervico-vaginal mucosa is naturally...
Diversity and Recognition Efficiency of T Cell Responses to Cancer
Stuge, Tor B, Holmes, Susan P, Saharan, Sahdev, Tuettenberg, Andrea, Roederer, Mario, Weber, Jeffrey S, ...
State-of-the art analysis of patients' response to melanoma vaccines yields lessons about cancer vaccines and rationale vaccine design in general
Memory T cells have gene expression patterns intermediate between naïve and effector
Holmes, Susan, He, Michael, Xu, Tong, Lee, Peter P.
The biological basis underlying differentiation of naïve (NAI) T cells into effector (EFFE) and memory (MEM) cells is incompletely understood. Furthermore, whether NAI T cells serially differentiate...
Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer
Kohrt, Holbrook E, Nouri, Navid, Nowels, Kent, Johnson, Denise, Holmes, Susan, Lee, Peter P
Chen, Daniel S, Soen, Yoav, Stuge, Tor B, Lee, Peter P, Weber, Jeffrey S, Brown, Patrick O, ...
Patients vaccinated with melanoma-associated peptides show a wide diversity of responses, analysis of which may help us understand the differing clinical responses to such vaccines.
Molldrem, Jeffrey J., Lee, Peter P., Kant, Shreya, Wieder, Eric, Jiang, Weidong, Lu, Sijie, ...
We have shown that cytotoxic T lymphocytes specific for PR1, an HLA-A2–restricted nonopeptide derived from proteinase 3, kill leukemia cells and may contribute to the elimination of chronic...
Chang, Theresa L.-Y., Chang, Chia-Hwa, Simpson, David A., Xu, Qiang, Martin, Patrick K., Lagenaur, Laurel A., ...
The predominant mode of HIV transmission worldwide is via heterosexual contact, with the cervico-vaginal mucosa being the main portal of entry in women. The cervico-vaginal mucosa is naturally...
Diversity and Recognition Efficiency of T Cell Responses to Cancer
Stuge, Tor B, Holmes, Susan P, Saharan, Sahdev, Tuettenberg, Andrea, Roederer, Mario, Weber, Jeffrey S, ...
State-of-the art analysis of patients' response to melanoma vaccines yields lessons about cancer vaccines and rationale vaccine design in general
Memory T cells have gene expression patterns intermediate between naïve and effector
Holmes, Susan, He, Michael, Xu, Tong, Lee, Peter P.
The biological basis underlying differentiation of naïve (NAI) T cells into effector (EFFE) and memory (MEM) cells is incompletely understood. Furthermore, whether NAI T cells serially differentiate...
Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer
Kohrt, Holbrook E, Nouri, Navid, Nowels, Kent, Johnson, Denise, Holmes, Susan, Lee, Peter P
Chen, Daniel S, Soen, Yoav, Stuge, Tor B, Lee, Peter P, Weber, Jeffrey S, Brown, Patrick O, ...
Patients vaccinated with melanoma-associated peptides show a wide diversity of responses, analysis of which may help us understand the differing clinical responses to such vaccines.
Liu, Xiaowen, Lagenaur, Laurel A., Simpson, David A., Essenmacher, Kirsten P., Frazier-Parker, Courtney L., Liu, Yang, ...
Women are at significant risk of human immunodeficiency virus (HIV) infection, with the cervicovaginal mucosa serving as a major portal for virus entry. Female-initiated preventatives, including...
Critchley-Thorne, Rebecca J, Yan, Ning, Nacu, Serban, Weber, Jeffrey, Holmes, Susan P, Lee, Peter P
Prompted by altered expression patterns of interferon-responsive genes in T and B cells, Peter Lee and colleagues find that lymphocytes from melanoma patients have defects in interferon signaling.
Yee, Cassian, Thompson, John A., Roche, Patrick, Byrd, David R., Lee, Peter P., Piepkorn, Michael, ...
Current strategies for the immunotherapy of melanoma include augmentation of the immune response to tumor antigens represented by melanosomal proteins such as tyrosinase, gp100, and MART-1. The...
Dynamics and Potential Impact of the Immune Response to Chronic Myelogenous Leukemia
Kim, Peter S., Lee, Peter P., Levy, Doron
Recent mathematical models have been developed to study the dynamics of chronic myelogenous leukemia (CML) under imatinib treatment. None of these models incorporates the anti-leukemia immune...