Osteoactivin/HGFIN: is it a tumor suppressor or mediator of metastasis in breast cancer? (2007)
Rose, April AN, Siegel, Peter M
No abstract available.
Thesis (Ph.D.) -- McMaster University, 1999.
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
Rauh, Michael J., Blackmore, Valerie, Andrechek, Eran R., Tortorice, Christopher G., Daly, Roger, Lai, Venus Ka-Man, ...
The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial...
Lee, Richard J., Albanese, Chris, Fu, Maofu, D'Amico, Mark, Lin, Bing, Watanabe, Genichi, ...
The neu (c-erbB-2) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. Herein, cyclin D1 protein levels were increased in mammary tumors...
Siegel, Peter M., Shu, Weiping, Cardiff, Robert D., Muller, William J., Massagué, Joan
The influence of transforming growth factor β (TGF-β) signaling on Neu-induced mammary tumorigenesis and metastasis was examined with transgenic mouse models. We generated mice expressing an...
De Candia, Paola, Solit, David B., Giri, Dilip, Brogi, Edi, Siegel, Peter M., Olshen, Adam B., ...
Id proteins bind basic helix–loop–helix transcription factors and function as dominant negative inhibitors of gene expression. Id1 and Id3 are required for the recruitment of bone marrow-derived...
Genes that mediate breast cancer metastasis to lung
Minn, Andy J., Gupta, Gaorav P., Siegel, Peter M., Bos, Paula D., Shu, Weiping, Giri, Dilip D., ...
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs....
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis
Andrechek, Eran R., Hardy, William R., Siegel, Peter M., Rudnicki, Michael A., Cardiff, Robert D., Muller, William J.
The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20–30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of...
Rauh, Michael J., Blackmore, Valerie, Andrechek, Eran R., Tortorice, Christopher G., Daly, Roger, Lai, Venus Ka-Man, ...
The Grb2 and Shc adapter proteins play critical roles in coupling activated growth factor receptors to several cellular signaling pathways. To assess the role of these molecules in mammary epithelial...
Lee, Richard J., Albanese, Chris, Fu, Maofu, D'Amico, Mark, Lin, Bing, Watanabe, Genichi, ...
The neu (c-erbB-2) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. Herein, cyclin D1 protein levels were increased in mammary tumors...
Siegel, Peter M., Shu, Weiping, Cardiff, Robert D., Muller, William J., Massagué, Joan
The influence of transforming growth factor β (TGF-β) signaling on Neu-induced mammary tumorigenesis and metastasis was examined with transgenic mouse models. We generated mice expressing an...
De Candia, Paola, Solit, David B., Giri, Dilip, Brogi, Edi, Siegel, Peter M., Olshen, Adam B., ...
Id proteins bind basic helix–loop–helix transcription factors and function as dominant negative inhibitors of gene expression. Id1 and Id3 are required for the recruitment of bone marrow-derived...
Northey, Jason J., Chmielecki, Juliann, Ngan, Elaine, Russo, Caterina, Annis, Matthew G., Muller, William J., ...
Cooperation between the Neu/ErbB-2 and transforming growth factor β (TGF-β) signaling pathways enhances the invasive and metastatic capabilities of breast cancer cells; however, the underlying...