Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology (2006)
Thomas G. Smith, Jerome T. Brooks, George M. Balanos, Terence R. Lappin, D. Mark Layton, Dawn L. Leedham, ...
Physiological study of patients with Chuvash polycythemia (caused by mutation of VHL) reveals characteristics similar to those associated with acclimatization to the hypoxia of high altitude.
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology (2006)
Thomas G. Smith, Jerome T. Brooks, George M. Balanos, Terence R. Lappin, D. Mark Layton, Dawn L. Leedham, ...
Background The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular...
Tammie Bishop, Kah Weng Lau, Stuart K. Kim, Min Jiang, Delia O'Rourke, ...
Besides its known function of inactivating hypoxia-inducible factor (HIF), genetically engineered worms clearly demonstrate that there exist HIF-independent effects of the von Hippel- Lindau tumor...
Tammie Bishop, Kah Weng Lau, Stuart K. Kim, Min Jiang, Delia O'Rourke, ...
The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated α subunits of hypoxia-inducible factor (HIF). Although studies of...
McKenzie, Colin A., Abecasis, Gonçalo R., Keavney, Bernard, Forrester, Terrence, Ratcliffe, Peter J., Julier, Cécile, ...
Circulating angiotensin I-converting enzyme (ACE) levels are influenced by a major quantitative trait locus (QTL) that maps to the ACE gene. Phylogenetic and measured haplotype analyses have...
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, ...
Hypoxia-inducible factor-1 (HIF) is a transcription factor central to oxygen homeostasis. It is regulated via its α isoforms. In normoxia they are ubiquitinated by the von Hippel-Lindau E3 ligase...
Masson, Norma, Willam, Carsten, Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.
Oxygen-dependent proteolytic destruction of hypoxia-inducible factor-α (HIF-α) subunits plays a central role in regulating transcriptional responses to hypoxia. Recent studies have defined a key...
Lavista-Llanos, Sofía, Centanin, Lázaro, Irisarri, Maximiliano, Russo, Daniela M., Gleadle, Jonathan M., Bocca, Silvia N., ...
In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a...
Bishop, Tammie, Lau, Kah Weng, Epstein, Andrew C. R, Kim, Stuart K, Jiang, Min, O'Rourke, Delia, ...
The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated α subunits of hypoxia-inducible factor (HIF). Although studies of...
Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, ...
Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor α subunits (HIF-1α and HIF-2α), leading to constitutive activation of...
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
Smith, Thomas G, Brooks, Jerome T, Balanos, George M, Lappin, Terence R, Layton, D. Mark, Leedham, Dawn L, ...
Physiological study of patients with Chuvash polycythemia (caused by mutation of VHL) reveals characteristics similar to those associated with acclimatization to the hypoxia of high altitude.
Centanin, Lázaro, Ratcliffe, Peter J, Wappner, Pablo
Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate...
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
Willam, Carsten, Masson, Norma, Tian, Ya-Min, Mahmood, S. Aleema, Wilson, Michael I., Bicknell, Roy, ...
Hypoxia-inducible factor-1 (HIF) is a transcription factor central to oxygen homeostasis. It is regulated via its α isoforms. In normoxia they are ubiquitinated by the von Hippel-Lindau E3 ligase...
Masson, Norma, Willam, Carsten, Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J.
Oxygen-dependent proteolytic destruction of hypoxia-inducible factor-α (HIF-α) subunits plays a central role in regulating transcriptional responses to hypoxia. Recent studies have defined a key...
Lavista-Llanos, Sofía, Centanin, Lázaro, Irisarri, Maximiliano, Russo, Daniela M., Gleadle, Jonathan M., Bocca, Silvia N., ...
In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a...
Bishop, Tammie, Lau, Kah Weng, Epstein, Andrew C. R, Kim, Stuart K, Jiang, Min, O'Rourke, Delia, ...
The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated α subunits of hypoxia-inducible factor (HIF). Although studies of...
Raval, Raju R., Lau, Kah Weng, Tran, Maxine G. B., Sowter, Heidi M., Mandriota, Stefano J., Li, Ji-Liang, ...
Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor α subunits (HIF-1α and HIF-2α), leading to constitutive activation of...
Centanin, Lázaro, Ratcliffe, Peter J, Wappner, Pablo
Hypoxia-Inducible Factor (HIF) prolyl hydroxylase domains (PHDs) have been proposed to act as sensors that have an important role in oxygen homeostasis. In the presence of oxygen, they hydroxylate...
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
Smith, Thomas G, Brooks, Jerome T, Balanos, George M, Lappin, Terence R, Layton, D. Mark, Leedham, Dawn L, ...
Physiological study of patients with Chuvash polycythemia (caused by mutation of VHL) reveals characteristics similar to those associated with acclimatization to the hypoxia of high altitude.
Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., ...
Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition of...
HIF-1 and HIF-2: working alone or together in hypoxia?
Erythropoietin (EPO) is the hormonal regulator of red cell production and provided the paradigm for oxygen-regulated gene expression that led to the discovery of hypoxia-inducible factor (HIF). In...
Talks, Katherine L., Turley, Helen, Gatter, Kevin C., Maxwell, Patrick H., Pugh, Christopher W., Ratcliffe, Peter J., ...
The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in diverse processes such as glycolysis and angiogenesis. Induction of the...
The human side of hypoxia-inducible factor
Smith, Thomas G, Robbins, Peter A, Ratcliffe, Peter J
When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that the...
Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3−/− Mice▿
Bishop, Tammie, Gallagher, Denis, Pascual, Alberto, Lygate, Craig A., De Bono, Joseph P., Nicholls, Lynn G., ...
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo,...