Peter C. L. Beverley

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression

Stanton, Tara, Boxall, Sally, Hirai, Kouzo, Dawes, Ritu, Tonks, Susan, Yasui, Tomoyo, ...

CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression

Stanton, Tara, Boxall, Sally, Hirai, Kouzo, Dawes, Ritu, Tonks, Susan, Yasui, Tomoyo, ...

CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...

CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells

Piercy, Jenny, Petrova, Svetla, Tchilian, Elma Z, Beverley, Peter C L

CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45−/− bone marrow dendritic cells (BMDC)...

Prolonged exposure of naïve CD8+ T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length

Wallace, Diana L, Bérard, Marion, Soares, Maria V D, Oldham, Janine, Cook, Joanne E, Akbar, Arne N, ...

Interleukin (IL)-7 and IL-15 are cytokines implicated in homeostatic control of the peripheral CD8 T-cell pool. We compared the effects of IL-7 and IL-15 on survival and proliferation of purified...

Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo

Reed, John R., Vukmanovic-Stejic, Milica, Fletcher, Jean M., Soares, Maria Vieira D., Cook, Joanne E., Orteu, Catherine H., ...

The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear. To investigate this, we injected...

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, Derek C., Wallace, Diana, Zhang, Yan, De Lara, Catherine, Worth, Andrew T., Ghattas, Hala, ...

Memory T cells can be divided into central–memory (TCM) and effector–memory (TEM) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not...

Serotype-Specific and Age-Dependent Generation of Pneumococcal Polysaccharide-Specific Memory B-Cell and Antibody Responses to Immunization with a Pneumococcal Conjugate Vaccine▿

Clutterbuck, Elizabeth A., Oh, Sarah, Hamaluba, Mainga, Westcar, Sharon, Beverley, Peter C. L., Pollard, Andrew J.

Glycoconjugate vaccines have dramatically reduced the incidence of encapsulated bacterial diseases in toddlers under 2 years of age, but vaccine-induced antibody levels in this age group wane...

In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection

Zhang, Yan, Wallace, Diana L, De Lara, Catherine M, Ghattas, Hala, Asquith, Becca, Worth, Andrew, ...

Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis. We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium-enriched...