Exon Silencing by UAGG Motifs in Response to Neuronal Excitation (2007)
Alternative pre-mRNA splicing plays fundamental roles in neurons by generating functional diversity in proteins associated with the communication and connectivity of the synapse. The CI cassette of...
Xu, Xue-Ming, Mix, Heiko, Carlson, Bradley A., Grabowski, Paula J., Gladyshev, Vadim N., Berry, Marla J., ...
Selenocysteine (Sec) is inserted into selenoproteins co-translationally with the help of various cis- and trans-acting factors. The specific mechanisms of Sec biosynthesis and insertion into protein...
A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs (2005)
Kyoungha Han, Gene Yeo, Ping An, Christopher B. Burge, Paula J. Grabowski
Many genes are alternatively spliced, but the signals that regulate the process are unclear. These authors have found a sequence motif that appears to function at many alternatively spliced genes.
A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs (2005)
Kyoungha Han, Gene Yeo, Ping An, Christopher B. Burge, Paula J. Grabowski
Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial...
Function of quaking in myelination: Regulation of alternative splicing
Wu, Jiang I., Reed, Robyn B., Grabowski, Paula J., Artzt, Karen
Proteomic diversity is frequently achieved by alternative RNA-splicing events that can be fine-tuned in tissue-specific and developmentally regulated ways. Understanding this type of genetic...
A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs
Han, Kyoungha, Yeo, Gene, An, Ping, Burge, Christopher B, Grabowski, Paula J
Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial...
Liu, Haiying, Zhang, Wenqing, Reed, Robyn B, Liu, Weiqun, Grabowski, Paula J
The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of...
Zhang, Wenqing, Liu, Haiying, Han, Kyoungha, Grabowski, Paula J
Alternative RNA splicing generates extensive proteomic diversity in the nervous system, yet few neural-specific RNA binding proteins have been implicated in splicing control. Here we show that the...
Function of quaking in myelination: Regulation of alternative splicing
Wu, Jiang I., Reed, Robyn B., Grabowski, Paula J., Artzt, Karen
Proteomic diversity is frequently achieved by alternative RNA-splicing events that can be fine-tuned in tissue-specific and developmentally regulated ways. Understanding this type of genetic...
A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs
Han, Kyoungha, Yeo, Gene, An, Ping, Burge, Christopher B, Grabowski, Paula J
Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial...
Liu, Haiying, Zhang, Wenqing, Reed, Robyn B, Liu, Weiqun, Grabowski, Paula J
The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of...
Zhang, Wenqing, Liu, Haiying, Han, Kyoungha, Grabowski, Paula J
Alternative RNA splicing generates extensive proteomic diversity in the nervous system, yet few neural-specific RNA binding proteins have been implicated in splicing control. Here we show that the...
Exon Silencing by UAGG Motifs in Response to Neuronal Excitation
Alternative pre-mRNA splicing plays fundamental roles in neurons by generating functional diversity in proteins associated with the communication and connectivity of the synapse. The CI cassette of...