Borggren, Marie, Repits, Johanna, Kuylenstierna, Carlotta, Sterjovski, Jasminka, Churchill, Melissa J, Purcell, Damian FJ, ...
Abstract Background At early stages of infection CCR5 is the predominant HIV-1 coreceptor, but in approximately 50% of those infected CXCR4-using viruses emerge with disease progression. This...
Sterjovski, Jasminka, Churchill, Melissa J, Ellett, Anne, Gray, Lachlan R, Roche, Michael J, Dunfee, Rebecca L, ...
Abstract Background CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the...
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo (2007)
Gorry, Paul R, McPhee, Dale A, Verity, Erin, Dyer, Wayne B, Wesselingh, Steven L, Learmont, Jennifer, ...
Abstract In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and...
Gray, Lachlan, Churchill, Melissa J, Sterjovski, Jasminka, Witlox, Kristie, Learmont, Jennifer C, Sullivan, John S, ...
Abstract Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with attenuated, nef -deleted variants of human immunodeficiency virus type 1...
Churchill, Melissa J, Chiavaroli, Lisa, Wesselingh, Steven L, Gorry, Paul R
Abstract Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with nef -deleted, attenuated strains of human immunodeficiency virus type 1...
Gorry, Paul R., Howard, Jane L., Churchill, Melissa J., Anderson, Jenny L., Cunningham, Anthony, Adrian, Deborah, ...
Astrocytes infected with human immunodeficiency virus type 1 (HIV-1) produce only minimal quantities of virus. The molecular events that limit acute-phase HIV-1 infection of astrocytes were examined...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Gorry, Paul R., Taylor, Joann, Holm, Geoffrey H., Mehle, Andrew, Morgan, Tom, Cayabyab, Mark, ...
Most human immunodeficiency virus type 1 (HIV-1) viruses in the brain use CCR5 as the principal coreceptor for entry into a cell. However, additional phenotypic characteristics are necessary for...
Ohagen, Asa, Devitt, Amy, Kunstman, Kevin J., Gorry, Paul R., Rose, Patrick P., Korber, Bette, ...
The genetic evolution of human immunodeficiency virus type 1 (HIV-1) in the brain is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the virus. Few primary...
Holm, Geoffrey H., Zhang, Chengsheng, Gorry, Paul R., Peden, Keith, Schols, Dominique, De Clercq, Erik, ...
Apoptosis of uninfected bystander CD4+ T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander...
Ong, Chi L., Thorpe, Janine C., Gorry, Paul R., Bannwarth, Sylvie, Jaworowski, Anthony, Howard, Jane L., ...
Acute human immunodeficiency virus type 1 (HIV-1) replication in astrocytes produces minimal new virus particles due, in part, to inefficient translation of viral structural proteins despite high...
Churchill, Melissa J., Rhodes, David I., Learmont, Jennifer C., Sullivan, John S., Wesselingh, Steven L., Cooke, Ian R. C., ...
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) in a cohort of long-term survivors infected with an attenuated strain of HIV-1 acquired from a single source. Although the...
Gray, Lachlan, Churchill, Melissa J., Keane, Niamh, Sterjovski, Jasminka, Ellett, Anne M., Purcell, Damian F. J., ...
We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5Δ32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry...
Gorry, Paul R., Howard, Jane L., Churchill, Melissa J., Anderson, Jenny L., Cunningham, Anthony, Adrian, Deborah, ...
Astrocytes infected with human immunodeficiency virus type 1 (HIV-1) produce only minimal quantities of virus. The molecular events that limit acute-phase HIV-1 infection of astrocytes were examined...
Gorry, Paul R., Bristol, Greg, Zack, Jerome A., Ritola, Kimberly, Swanstrom, Ronald, Birch, Chris J., ...
The viral determinants that underlie human immunodeficiency virus type 1 (HIV-1) neurotropism are unknown, due in part to limited studies on viruses isolated from brain. Previous studies suggest that...
Gorry, Paul R., Taylor, Joann, Holm, Geoffrey H., Mehle, Andrew, Morgan, Tom, Cayabyab, Mark, ...
Most human immunodeficiency virus type 1 (HIV-1) viruses in the brain use CCR5 as the principal coreceptor for entry into a cell. However, additional phenotypic characteristics are necessary for...
Ohagen, Asa, Devitt, Amy, Kunstman, Kevin J., Gorry, Paul R., Rose, Patrick P., Korber, Bette, ...
The genetic evolution of human immunodeficiency virus type 1 (HIV-1) in the brain is distinct from that in lymphoid tissues, indicating tissue-specific compartmentalization of the virus. Few primary...
Holm, Geoffrey H., Zhang, Chengsheng, Gorry, Paul R., Peden, Keith, Schols, Dominique, De Clercq, Erik, ...
Apoptosis of uninfected bystander CD4+ T cells contributes to T-cell depletion during human immunodeficiency virus type 1 (HIV-1) pathogenesis. The viral and host mechanisms that lead to bystander...
Ong, Chi L., Thorpe, Janine C., Gorry, Paul R., Bannwarth, Sylvie, Jaworowski, Anthony, Howard, Jane L., ...
Acute human immunodeficiency virus type 1 (HIV-1) replication in astrocytes produces minimal new virus particles due, in part, to inefficient translation of viral structural proteins despite high...
Churchill, Melissa J., Rhodes, David I., Learmont, Jennifer C., Sullivan, John S., Wesselingh, Steven L., Cooke, Ian R. C., ...
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) in a cohort of long-term survivors infected with an attenuated strain of HIV-1 acquired from a single source. Although the...
Gray, Lachlan, Churchill, Melissa J., Keane, Niamh, Sterjovski, Jasminka, Ellett, Anne M., Purcell, Damian F. J., ...
We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5Δ32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry...
Dunfee, Rebecca L., Thomas, Elaine R., Gorry, Paul R., Wang, Jianbin, Taylor, Joann, Kunstman, Kevin, ...
HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4+ T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS...
Gray, Lachlan, Churchill, Melissa J, Sterjovski, Jasminka, Witlox, Kristie, Learmont, Jennifer C, Sullivan, John S, ...
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
Gorry, Paul R, McPhee, Dale A, Verity, Erin, Dyer, Wayne B, Wesselingh, Steven L, Learmont, Jennifer, ...
In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other...
Verity, Erin E., Zotos, Dimitra, Wilson, Kim, Chatfield, Catherine, Lawson, Victoria A., Dwyer, Dominic E., ...
The Sydney Blood Bank Cohort (SBBC) consists of eight blood transfusion recipients infected with nef-attenuated human immunodeficiency virus type 1 (HIV-1) acquired from a single donor. Here, we show...