Extracellular ATP and ADP mediate Ca2+ influx in Dictyostelium discoideum. (2008)
Ludlow, Melanie J., Traynor, David, Fisher, Paul R., Ennion, Steven J.
This is the author's final draft of the paper published as Purinergic Signalling, 2008, 4 (suppl. 1), pp. S5-S6. The original publication is available at www.springerlink.com, Doi:...
Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum (2007)
Annesley, Sarah J, Bandala-Sanchez, Esther, Ahmed, Afsar U, Fisher, Paul R
Abstract Background Filamin is an actin binding protein which is ubiquitous in eukaryotes and its basic structure is well conserved – an N-terminal actin binding domain followed by a series of...
Beech, Peter, Lay, Sui T., Gilson, Paul R., Fisher, Paul R.
To investigate protein import into the mitochondria of Dictyostelium discoideum, green fluorescent protein (GFP) was fused as a reporter protein either to variable lengths of the N-terminal region of...
The Dictyosteliumgenome encodes numerous RasGEFs with multiple biological roles (2005)
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
Abstract Background Dictyostelium discoideum is a eukaryote with a simple lifestyle and a relatively small genome whose sequence has been fully determined. It is widely used for studies on cell...
Project Pre-Gondola I. Geologic Investigations and Engineering Properties of Craters, (1998)
Fisher,Paul R., Kley,Ronald J., Jack,Harold A.
The report presents the results of preshot and postshot geologic and engineering properties investigations performed in conjunction with the Project Pre-Gondola I cratering experiment series. The...
Dictyostelium RasD is required for normal phototaxis, but not differentiation
Wilkins, Andrew, Khosla, Meenal, Fraser, Derek J., Spiegelman, George B., Fisher, Paul R., Weeks, Gerald, ...
RasD, a Dictyostelium homolog of mammalian Ras, is maximally expressed during the multicellular stage of development. Normal Dictyostelium aggregates are phototactic and thermotactic, moving towards...
Gilson, Paul R., Yu, Xuan-Chuan, Hereld, Dale, Barth, Christian, Savage, Amelia, Kiefel, Ben R., ...
In bacteria, the protein FtsZ is the principal component of a ring that constricts the cell at division. Though all mitochondria probably arose through a single, ancient bacterial endosymbiosis, the...
Wilczynska, Zofia, Happle, Kathrin, Müller-Taubenberger, Annette, Schlatterer, Christina, Malchow, Dieter, Fisher, Paul R.
Ca2+ responses to two chemoattractants, folate and cyclic AMP (cAMP), were assayed in Dictyostelium D. discoideum mutants deficient in one or both of two abundant Ca2+-binding proteins of the...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Ahmed, Afsar U., Beech, Peter L., Lay, Sui T., Gilson, Paul R., Fisher, Paul R.
To investigate protein import into the mitochondria of Dictyostelium discoideum, green fluorescent protein (GFP) was fused as a reporter protein either to variable lengths of the N-terminal region of...
Dictyostelium RasD is required for normal phototaxis, but not differentiation
Wilkins, Andrew, Khosla, Meenal, Fraser, Derek J., Spiegelman, George B., Fisher, Paul R., Weeks, Gerald, ...
RasD, a Dictyostelium homolog of mammalian Ras, is maximally expressed during the multicellular stage of development. Normal Dictyostelium aggregates are phototactic and thermotactic, moving towards...
Gilson, Paul R., Yu, Xuan-Chuan, Hereld, Dale, Barth, Christian, Savage, Amelia, Kiefel, Ben R., ...
In bacteria, the protein FtsZ is the principal component of a ring that constricts the cell at division. Though all mitochondria probably arose through a single, ancient bacterial endosymbiosis, the...
Wilczynska, Zofia, Happle, Kathrin, Müller-Taubenberger, Annette, Schlatterer, Christina, Malchow, Dieter, Fisher, Paul R.
Ca2+ responses to two chemoattractants, folate and cyclic AMP (cAMP), were assayed in Dictyostelium D. discoideum mutants deficient in one or both of two abundant Ca2+-binding proteins of the...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Ahmed, Afsar U., Beech, Peter L., Lay, Sui T., Gilson, Paul R., Fisher, Paul R.
To investigate protein import into the mitochondria of Dictyostelium discoideum, green fluorescent protein (GFP) was fused as a reporter protein either to variable lengths of the N-terminal region of...
Bokko, Paul B., Francione, Lisa, Bandala-Sanchez, Esther, Ahmed, Afsar U., Annesley, Sarah J., Huang, Xiuli, ...
The complex cytopathology of mitochondrial diseases is usually attributed to insufficient ATP. AMP-activated protein kinase (AMPK) is a highly sensitive cellular energy sensor that is stimulated by...
Filamin repeat segments required for photosensory signalling in Dictyostelium discoideum
Annesley, Sarah J, Bandala-Sanchez, Esther, Ahmed, Afsar U, Fisher, Paul R
Fisher, Paul R., Heins, Royal D., Ehler, Niels, Lieth, J. Heinrich, Brogaard, Michael, Karlsen, Poul
Pattern-Based Medical Diagnosis on a Microcomputer*
Fisher, Paul R., Kurlander, David J.
A differential diagnosis microcomputer program has been written that utilizes both pattern-recognition and logical analysis in its algorithm. Together with auxilliary routines, the program (called...
Confronting Subjective Criteria in the Evaluation of Computer-Based Critiquing Advice
Rothschild, Michael A., Miller, Perry L., Fisher, Paul R., Weltin, Gregory G., Swett, Henry A.
There is a need for formal evaluation in the development of any computer-based expert systems. This may be quite difficult when judging a critiquing system, that is, a system which responds to a...
Great Expectations: Expectation Based Reasoning in Medical Diagnosis
Fisher, Paul R., Miller, Perry L., Swett, Henry A.
Several different approaches to knowledge representation for medical expert systems have been explored. We suggest that a modified version of the script formalism, which we term “expectation-based...