Paul D. Rennert

Requirement for the NF-kappa B family member Re1A in the development of secondary lymphoid organs (2002)

Alcamo, Elizabeth, Hacohen, Nir, Schulte, Leah C., Rennert, Paul D., Hynes, Richard O., Baltimore, David

The transcription factor nuclear factor (NF)-kappaB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-kappaB/ Rel family...

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

Nakano, Hiroyasu, Sakon, Sachiko, Koseki, Haruhiko, Takemori, Toshitada, Tada, Kurisu, Matsumoto, Mitsuru, ...

TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH2-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor...

Peyer's patches are required for oral tolerance to proteins

Fujihashi, Kohtaro, Dohi, Taeko, Rennert, Paul D., Yamamoto, Masafumi, Koga, Toshiya, Kiyono, Hiroshi, ...

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin β-receptor Ig fusion protein to generate mice lacking Peyer's patches. When...

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

De Fougerolles, Antonin R., Sprague, Andrew G., Nickerson-Nutter, Cheryl L., Chi-Rosso, Gloria, Rennert, Paul D., Gardner, Humphrey, ...

Adhesive interactions play an important role in inflammation by promoting leukocyte attachment and extravasation from the vasculature into the peripheral tissues. However, the importance of adhesion...

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

Jang, Myoung Ho, Kweon, Mi-Na, Iwatani, Koichi, Yamamoto, Masafumi, Terahara, Kazutaka, Sasakawa, Chihiro, ...

M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the...

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

Nakano, Hiroyasu, Sakon, Sachiko, Koseki, Haruhiko, Takemori, Toshitada, Tada, Kurisu, Matsumoto, Mitsuru, ...

TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH2-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor...

Peyer's patches are required for oral tolerance to proteins

Fujihashi, Kohtaro, Dohi, Taeko, Rennert, Paul D., Yamamoto, Masafumi, Koga, Toshiya, Kiyono, Hiroshi, ...

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin β-receptor Ig fusion protein to generate mice lacking Peyer's patches. When...

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

De Fougerolles, Antonin R., Sprague, Andrew G., Nickerson-Nutter, Cheryl L., Chi-Rosso, Gloria, Rennert, Paul D., Gardner, Humphrey, ...

Adhesive interactions play an important role in inflammation by promoting leukocyte attachment and extravasation from the vasculature into the peripheral tissues. However, the importance of adhesion...

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

Jang, Myoung Ho, Kweon, Mi-Na, Iwatani, Koichi, Yamamoto, Masafumi, Terahara, Kazutaka, Sasakawa, Chihiro, ...

M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the...

Induction of Colitis in Mice Deficient of Peyer’s Patches and Mesenteric Lymph Nodes Is Associated with Increased Disease Severity and Formation of Colonic Lymphoid Patches

Spahn, Thomas W., Herbst, Hermann, Rennert, Paul D., Lügering, Norbert, Maaser, Christian, Kraft, Mathias, ...

Inflammatory bowel disease is associated with immune activation in Peyer’s patches and mucosal lymph nodes. The role of these organs in dextran sodium sulfate (DSS)-induced colitis was...

Identification of proteoglycans as the APRIL-specific binding partners

Ingold, Karine, Zumsteg, Adrian, Tardivel, Aubry, Huard, Bertrand, Steiner, Quynh-Giao, Cachero, Teresa G., ...

B cell activating factor of the tumor necrosis factor (TNF) family (BAFF) and a proliferation-inducing ligand (APRIL) are closely related ligands within the TNF superfamily that play important roles...

Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses

Dohi, Taeko, Fujihashi, Kohtaro, Rennert, Paul D., Iwatani, Koichi, Kiyono, Hiroshi, McGhee, Jerry R.

To investigate the potential involvement of T helper (Th)2-type responses in murine models of intestinal inflammation, we used trinitrobenzene sulfonic acid (TNBS)–hapten to induce inflammatory...

Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

Kim, Dongku, Mebius, Reina E., MacMicking, John D., Jung, Steffen, Cupedo, Tom, Castellanos, Yaneth, ...

Proper lymph node (LN) development requires tumor necrosis factor–related activation-induced cytokine (TRANCE) expression. Here we demonstrate that the defective LN development in TRANCE−/−...

Essential Role of Lymph Nodes in Contact Hypersensitivity Revealed in Lymphotoxin-α–Deficient Mice

Rennert, Paul D., Hochman, Paula S., Flavell, Richard A., Chaplin, David D., Jayaraman, Sundararajan, Browning, Jeffrey L., ...

Lymph nodes (LNs) are important sentinal organs, populated by circulating lymphocytes and antigen-bearing cells exiting the tissue beds. Although cellular and humoral immune responses are induced in...

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

Matsushima, Akemi, Kaisho, Tsuneyasu, Rennert, Paul D., Nakano, Hiroyasu, Kurosawa, Kyoko, Uchida, Daisuke, ...

Both nuclear factor (NF)-κB–inducing kinase (NIK) and inhibitor of κB (IκB) kinase (IKK) have been implicated as essential components for NF-κB activation in response to many external stimuli....

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs

Alcamo, Elizabeth, Hacohen, Nir, Schulte, Leah C., Rennert, Paul D., Hynes, Richard O., Baltimore, David

The transcription factor nuclear factor (NF)-κB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-κB/ Rel family...