Germline polymorphisms as modulators of cancer phenotypes (2008)
Abstract Identifying the complete repertoire of genes and genetic variants that regulate the pathogenesis and progression of human disease is a central goal of post-genomic biomedical research. In...
Yu, Yiting, Kim, H Stanley, Chua, Hui, Lin, Chi, Sim, Siew, Lin, Daoxun, ...
Abstract Background The Gram-negative bacterium Burkholderia pseudomallei (Bp) is the causative agent of the human disease melioidosis. To understand the evolutionary mechanisms contributing to Bp...
Waiming Kong, Lawrence Tham, Kee Yew Wong, Patrick Tan
Support Vector Machine is used to classify data obtained from Amplified Fragment length Polymorphism screening of gastric cancer and normal tissue samples. Using the electrophoresis peak intensity...
Patterns of large-scale genomic variation in virulent and avirulent Burkholderia species
Ong, Catherine, Ooi, Chia Huey, Wang, Dongling, Chong, Hweeling, Ng, Kim Chong, Rodrigues, Fiona, ...
The human diseases melioidosis and glanders are caused by the bacteria Burkholderia pseudomallei and B. mallei respectively, and both species are regarded as potential biowarfare agents. We used B....
Ou, Keli, Ong, Catherine, Koh, Shze Yung, Rodrigues, Fiona, Sim, Siew Hoon, Wong, Daniel, ...
Natural isolates of pathogenic bacteria can exhibit a broad range of phenotypic traits. To investigate the molecular mechanisms contributing to such phenotypic variability, we compared the genomes,...
Patterns of large-scale genomic variation in virulent and avirulent Burkholderia species
Ong, Catherine, Ooi, Chia Huey, Wang, Dongling, Chong, Hweeling, Ng, Kim Chong, Rodrigues, Fiona, ...
The human diseases melioidosis and glanders are caused by the bacteria Burkholderia pseudomallei and B. mallei respectively, and both species are regarded as potential biowarfare agents. We used B....
Ou, Keli, Ong, Catherine, Koh, Shze Yung, Rodrigues, Fiona, Sim, Siew Hoon, Wong, Daniel, ...
Natural isolates of pathogenic bacteria can exhibit a broad range of phenotypic traits. To investigate the molecular mechanisms contributing to such phenotypic variability, we compared the genomes,...
Rodrigues, Fiona, Sarkar-Tyson, Mitali, Harding, Sarah V., Sim, Siew Hoon, Chua, Hui Hoon, Lin, Chi Ho, ...
Many microbial pathogens express specific virulence traits at distinct growth phases. To understand the molecular pathways linking bacterial growth to pathogenicity, we have characterized the growth...
The Airborne Metagenome in an Indoor Urban Environment
Tringe, Susannah G., Zhang, Tao, Liu, Xuguo, Yu, Yiting, Lee, Wah Heng, Yap, Jennifer, ...
The indoor atmosphere is an ecological unit that impacts on public health. To investigate the composition of organisms in this space, we applied culture-independent approaches to microbes harvested...
Yu, Kun, Ganesan, Kumaresan, Tan, Lay Keng, Laban, Mirtha, Wu, Jeanie, Zhao, Xiao Dong, ...
Successful tumor development and progression involves the complex interplay of both pro- and anti-oncogenic signaling pathways. Genetic components balancing these opposing activities are likely to...
Germline polymorphisms as modulators of cancer phenotypes
Identifying the complete repertoire of genes and genetic variants that regulate the pathogenesis and progression of human disease is a central goal of post-genomic biomedical research. In cancer,...
The Core and Accessory Genomes of Burkholderia pseudomallei: Implications for Human Melioidosis
Sim, Siew Hoon, Yu, Yiting, Lin, Chi Ho, Karuturi, R. Krishna M., Wuthiekanun, Vanaporn, Tuanyok, Apichai, ...
Natural isolates of Burkholderia pseudomallei (Bp), the causative agent of melioidosis, can exhibit significant ecological flexibility that is likely reflective of a dynamic genome. Using...