Patrick Seale, Jeff Ishibashi, Anthony Scimè, Michael A. Rudnicki
The gene Pax7 is shown to be a key regulator of muscle cell differentiation in specific populations of adult stem cells during muscle tissue regeneration.
Patrick Seale, Jeff Ishibashi, Anthony Scimè, Michael A. Rudnicki
CD45+:Sca1+ adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box...
Calibration of an optical power spectra measurement device /--by Patrick Seale Cheatham. (1976)
Thesis (Ph. D. - Optical Sciences)--University of Arizona.
Sabourin, Luc A., Seale, Patrick, Wagner, Julian, Rudnicki, Michael A.
We have demonstrated that a novel Ste20-related kinase, designated SLK, mediates apoptosis and actin stress fiber dissolution through distinct domains generated by caspase 3 cleavage. Overexpression...
Seale, Patrick, Ishibashi, Jeff, Scimè, Anthony, Rudnicki, Michael A
CD45+:Sca1+ adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box...
Sabourin, Luc A., Seale, Patrick, Wagner, Julian, Rudnicki, Michael A.
We have demonstrated that a novel Ste20-related kinase, designated SLK, mediates apoptosis and actin stress fiber dissolution through distinct domains generated by caspase 3 cleavage. Overexpression...
Seale, Patrick, Ishibashi, Jeff, Scimè, Anthony, Rudnicki, Michael A
CD45+:Sca1+ adult stem cells isolated from uninjured muscle do not display any myogenic potential, whereas those isolated from regenerating muscle give rise to myoblasts expressing the paired-box...
PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
Handschin, Christoph, Kobayashi, Yvonne M., Chin, Sherry, Seale, Patrick, Campbell, Kevin P., Spiegelman, Bruce M.
The coactivator PGC-1α mediates key responses of skeletal muscle to motor nerve activity. We show here that neuregulin-stimulated phosphorylation of PGC-1α and GA-binding protein (GABP) allows...
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
Kuang, Shihuan, Chargé, Sophie B., Seale, Patrick, Huh, Michael, Rudnicki, Michael A.
We assessed viable Pax7−/− mice in 129Sv/J background and observed reduced growth and marked muscle wasting together with a complete absence of functional satellite cells. Acute injury resulted...
Sabourin, Luc A., Girgis-Gabardo, Adele, Seale, Patrick, Asakura, Atsushi, Rudnicki, Michael A.
To gain insight into the regeneration deficit of MyoD−/− muscle, we investigated the growth and differentiation of cultured MyoD−/− myogenic cells. Primary MyoD−/− myogenic cells...
Myogenic specification of side population cells in skeletal muscle
Asakura, Atsushi, Seale, Patrick, Girgis-Gabardo, Adele, Rudnicki, Michael A.
Skeletal muscle contains myogenic progenitors called satellite cells and muscle-derived stem cells that have been suggested to be pluripotent. We further investigated the differentiation potential of...
Megf10 regulates the progression of the satellite cell myogenic program
Holterman, Chet E., Le Grand, Fabien, Kuang, Shihuan, Seale, Patrick, Rudnicki, Michael A.
We identify here the multiple epidermal growth factor repeat transmembrane protein Megf10 as a quiescent satellite cell marker that is also expressed in skeletal myoblasts but not in differentiated...
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura, Shingo, Seale, Patrick, Tomaru, Takuya, Erdjument-Bromage, Hediye, Cooper, Marcus P., Ruas, Jorge L., ...
Brown fat is a specialized tissue that can dissipate energy and counteract obesity through a pattern of gene expression that greatly increases mitochondrial content and uncoupled respiration. PRDM16...