Patricia Earl

VSV/MVA vaccine rapidly elicits SIV antibodies and local and systemic SIV T cell responses in macaque neonates but does not prevent SIV dissemination after oral challenge (2008)

Abel, Kristina, Van Rompay, Koen KA, Eastlick, Juliet, Moore, Joseph, Lemieux, Mathieu, Schmidt, Kimberly, ...

No abstract available.

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals (2005)

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Abstract Background Oral infection of infant macaques with simian immunodeficiency virus (SIV) is a useful animal model to test interventions to reduce postnatal HIV transmission via breast-feeding....

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

Belyakov, Igor M., Derby, Michael A., Ahlers, Jeffrey D., Kelsall, Brian L., Earl, Patricia, Moss, Bernard, ...

Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a mucosal cytotoxic T lymphocyte (CTL) response is an important feature for an effective HIV vaccine....

Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

Belyakov, Igor M., Wyatt, Linda S., Ahlers, Jeffrey D., Earl, Patricia, Pendleton, C. David, Kelsall, Brian L., ...

To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to...

Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251

Van Rompay, Koen K. A., Greenier, Jennifer L., Cole, Kelly Stefano, Earl, Patricia, Moss, Bernard, Steckbeck, Jonathan D., ...

There is an urgent need for active immunization strategies that, if administered shortly after birth, could protect infants in developing countries from acquiring human immunodeficiency virus (HIV)...

Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses

Belyakov, Igor M., Earl, Patricia, Dzutsev, Amiran, Kuznetsov, Vladimir A., Lemon, Michael, Wyatt, Linda S., ...

The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the...

Highly Effective Control of an AIDS Virus Challenge in Macaques by Using Vesicular Stomatitis Virus and Modified Vaccinia Virus Ankara Vaccine Vectors in a Single-Boost Protocol

Ramsburg, Elizabeth, Rose, Nina F., Marx, Preston A., Mefford, Megan, Nixon, Douglas F., Moretto, Walter J., ...

Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency...

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus

Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, Damon, Inger, Smith, Scott K., Zhou, Yi-Hua, ...

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human γ1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL)...

Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge

Belyakov, Igor M., Derby, Michael A., Ahlers, Jeffrey D., Kelsall, Brian L., Earl, Patricia, Moss, Bernard, ...

Mucosal tissues are major sites of HIV entry and initial infection. Thus, the induction of a mucosal cytotoxic T lymphocyte (CTL) response is an important feature for an effective HIV vaccine....

Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6 Envelope Protein

Belyakov, Igor M., Wyatt, Linda S., Ahlers, Jeffrey D., Earl, Patricia, Pendleton, C. David, Kelsall, Brian L., ...

To improve the safety of recombinant vaccinia virus vaccines, modified vaccinia virus Ankara (MVA) has been employed, because it has a replication defect in most mammalian cells. Here we apply MVA to...

Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251

Van Rompay, Koen K. A., Greenier, Jennifer L., Cole, Kelly Stefano, Earl, Patricia, Moss, Bernard, Steckbeck, Jonathan D., ...

There is an urgent need for active immunization strategies that, if administered shortly after birth, could protect infants in developing countries from acquiring human immunodeficiency virus (HIV)...

Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses

Belyakov, Igor M., Earl, Patricia, Dzutsev, Amiran, Kuznetsov, Vladimir A., Lemon, Michael, Wyatt, Linda S., ...

The concern about bioterrorism with smallpox has raised the possibility of widespread vaccination, but the greater prevalence of immunocompromised individuals today requires a safer vaccine, and the...

Highly Effective Control of an AIDS Virus Challenge in Macaques by Using Vesicular Stomatitis Virus and Modified Vaccinia Virus Ankara Vaccine Vectors in a Single-Boost Protocol

Ramsburg, Elizabeth, Rose, Nina F., Marx, Preston A., Mefford, Megan, Nixon, Douglas F., Moretto, Walter J., ...

Previous studies have shown that vaccination and boosting of rhesus macaques with attenuated vesicular stomatitis virus (VSV) vectors encoding Env and Gag proteins of simian immunodeficiency...

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus

Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, Damon, Inger, Smith, Scott K., Zhou, Yi-Hua, ...

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human γ1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL)...

Characterization of Chimpanzee/Human Monoclonal Antibodies to Vaccinia Virus A33 Glycoprotein and Its Variola Virus Homolog In Vitro and in a Vaccinia Virus Mouse Protection Model▿

Chen, Zhaochun, Earl, Patricia, Americo, Jeffrey, Damon, Inger, Smith, Scott K., Yu, Fujuan, ...

Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human γ1 heavy-chain constant...