Min-Hyuk Yoo

Mouse models for assessing the role of selenoproteins in health and development (2006)

Carlson, Bradley A., Xu, Xue-Ming, Shrimali, Rajeev, Sengupta, Aniruddha, Yoo, Min-Hyuk, Zhong, Nianxin, ...

Mouse models have been generated to assess the roles of selenoproteins involved with housekeeping tasks and/or stress-related phenomena in development and health. Each mouse model has taken advantage...

Mammalian and other eukaryotic selenocysteine tRNAs (2006)

Carlson, Bradley A., Xu, Xue-Ming, Shrimali, Rajeev, Sengupta, Aniruddha, Yoo, Min-Hyuk, Irons, Robert, ...

Selenocysteine (Sec) tRNA occupies a prominent position in the expression of selenoproteins as it is essential for their synthesis and it provides the means by which selenium is co-translationally...

Thioredoxin Reductase 1 Deficiency Reverses Tumor Phenotype and Tumorigenicity of Lung Carcinoma Cells (2006)

Yoo, Min-Hyuk, Xu, Xue-Ming, Carlson, Bradley A., Gladyshev, Vadim N., Hatfield, Dolph L.

Dietary selenium has potent cancer prevention activity. Both low molecular weight selenocompounds and selenoproteins are implicated in this effect. Thioredoxin reductase 1 (TR1) is one of the major...

Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.

Lee, Mina, You, Hye-Jin, Cho, Sung-Hoon, Woo, Chang-Hoon, Yoo, Min-Hyuk, Joe, Eun-Hye, ...

Exogenous application of beta-amyloid (Abeta(25-35), a fragment of Abeta(1-42)) significantly elevated levels of reactive oxygen species (ROS) in C6 astroglioma cells, as measured by confocal...

Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.

Lee, Mina, You, Hye-Jin, Cho, Sung-Hoon, Woo, Chang-Hoon, Yoo, Min-Hyuk, Joe, Eun-Hye, ...

Exogenous application of beta-amyloid (Abeta(25-35), a fragment of Abeta(1-42)) significantly elevated levels of reactive oxygen species (ROS) in C6 astroglioma cells, as measured by confocal...

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Yoo, Min-Hyuk, Xu, Xue-Ming, Carlson, Bradley A., Patterson, Andrew D., Gladyshev, Vadim N., Hatfield, Dolph L.

Thioredoxin reductase 1 (TR1) is a major redox regulator in mammalian cells. As an important antioxidant selenoprotein, TR1 is thought to participate in cancer prevention, but is also known to be...

A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3′-UTR

Yoo, Min-Hyuk, Xu, Xue-Ming, Turanov, Anton A., Carlson, Bradley A., Gladyshev, Vadim N., Hatfield, Dolph L.

Selenocysteine insertion into protein in mammalian cells requires RNA elements in the 3′-untranslated regions (3′-UTRs) of selenoprotein genes. The occurrence of these conserved sequences should...