STRING and STITCH: known and predicted interactions between proteins and chemicals (2008)
Lars J. Jensen, Michael Kuhn, Manuel Stark, Samuel Chaffron, Christian Von Mering, Peer Bork
Information on protein-protein and protein-chemical interactions is essential for understanding cellular functions. The STRING and STITCH web resources integrate interaction evidence derived from...
Makarynskyy, Oleg, Makarynska, Dina, Kuhn, Michael, Featherstone, Will
In the present study, the artificial intelligence meshless methodology of neural networks was used to predict hourly sea level variations for the following 24 hours, as well as for half-daily, daily,...
Makarynskyy, Oleg, Kuhn, Michael, Makarynska, Dina, Featherstone, Will. E.
The knowledge of near-shore sea-level variations is of great importance in applications such as ocean engineering and safe navigation. It also plays an essential role in the practical realisation of...
Makarynskyy, Oleg, Makarynska, Dina, Kuhn, Michael, Featherstone, Will
In the present study, the artificial intelligence meshless methodology of neural networks was used to predict hourly sea level variations for the following 24 hours, as well as for half-daily, daily,...
Makarynskyy, Oleg, Kuhn, Michael, Makarynska, Dina, Featherstone, Will. E.
The knowledge of near-shore sea-level variations is of great importance in applications such as ocean engineering and safe navigation. It also plays an essential role in the practical realisation of...
Makarynskyy, Oleg, Kuhn, Michael, Makarynska, Dina, Featherstone, Will. E.
The knowledge of near-shore sea-level variations is of great importance in applications such as ocean engineering and safe navigation. It also plays an essential role in the practical realisation of...
Parallel AMG on Distributed Memory Computers (2000)
Gundolf Haase, Michael Kuhn, Stefan Reitzinger
Algebraic Multigrid (AMG) methods are well suited as preconditioners for iterative solvers of linear systems of equations which are sparse, symmetric positive definite and stem from a finite element...
Scientific Computing Tools For 3D Magnetic Field Problems (2000)
Michael Kuhn, Ulrich Langer, Joachim Schoberl
3D magnetic field problems are challenging not only because of interesting applications in the industry but also from the mathematical point of view. In order to handle technical magnetic field...
Kuhn, Michael., Deutsche Geodatische Kommission.
Thesis (D.-Ing.)--Universitat Karlsruhe.
Abductive Coreference by Model Construction (1999)
Michael K Uhn, Peter Baumgartner, Michael Kuhn
. In this paper, we argue that the resolution of anaphoric expressions in an utterance is essentially an abductive task following [HSAM93] who use a weighted abduction scheme on horn clauses to deal...
. This paper extends a calculus for first-order logic that combines the inference mechanism of hyperresolution with the more informative structure of analytic tableaux and that has been introduced as...
Extending Hyper Tableaux with Rigid E-Unification (1997)
Peter Baumgartner, Michael Kuhn, Bernhard Beckert
instance, the modified calculus still yields a decision procedure for the function-free case (unlike hyper resolution). The second improvement is the extension with a dedicated inference rule for...
TRANSCG - A Scientific Program for Testing Parallel Algorithms (Documentation of Version 2) (1996)
this paper is organized as follows. In section 2 the capabilities of the program and the required input data are described. In section 3 we explain the geometrical input data and the standard input...
this paper is organized as follows. In section 2 the capabilities of the program and the required input data are described. In section 3 we explain the geometrical input data and the standard input...
Extending Hyper Tableaux with Rigid E-Unification (1996)
Peter Baumgartner, Michael Kuhn, Bernhard Beckert
res. For instance, the modified calculus still yields a decision procedure for the function-free case (unlike hyper resolution). The second improvement is the extension with a dedicated inference...
Changing the world one life at a time--[videorecording] /--by Michael Kuhn. (1996)
Title from cassette label.
Personenregister zu Carl Jacob Burckhardts "Memorabilien" / (1992)
Diplomarb. Verband der Bibliotheken und der Bibliothekarinnen/Bibliothekare der Schweiz.
Zinkspiegel im Serum bei Kindern mit akuter lymphoblastischer Leukose (ALL). (1989)
Greifswald, Univ., Diss. A, 1989 (Nicht f.d. Austausch).
Göttingen, Univ., Diss., 1986.
Extending Hyper Tableaux with Rigid E-Unification (1970)
Peter Baumgartner, Michael Kuhn, Bernhard Beckert
instance, the modified calculus still yields a decision procedure for the function-free case (unlike hyper resolution). The second improvement is the extension with a dedicated inference rule for...
Parallel Multigrid 3D Maxwell Solvers (1970)
Gundolf Haase, Michael Kuhn, Ulrich Langer
3D magnetic field problems are challenging not only because of interesting applications in the industry but also from the mathematical point of view. In the magnetostatic case, our Maxwell solver is...
Endogenous firm location is analyzed in a discrete two-region-two-firm model of product differentiation. In a non-cooperative game, two regional governments first decide on the imposition (or...
Hauf, Nadja, Goebel, Werner, Fiedler, Franz, Sokolovic, Zeljka, Kuhn, Michael
As previously reported, Listeria monocytogenes infection of P388D1 macrophages results in a rapid induction of NF-κB DNA-binding activity. Here we show that this induction of NF-κB activity occurs...
Listeria Pathogenesis and Molecular Virulence Determinants
Vázquez-Boland, José A., Kuhn, Michael, Berche, Patrick, Chakraborty, Trinad, Domínguez-Bernal, Gustavo, Goebel, Werner, ...
The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and debilitated or...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Daniels, Justin, Kuhn, Michael
Internalization of Listeria monocytogenes into human brain microvascular endothelial cells (HBMEC) has recently been demonstrated to be dependent upon the inlB gene. In the present scanning electron...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Weiglein, Inge, Bubert, Andreas, Engelbrecht, Fredi, ...
Invasion of endothelial tissues may be crucial in a Listeria monocytogenes infection leading to meningitis and/or encephalitis. Internalization of L. monocytogenes into endothelial cells has been...
Rouquette-Loughlin, Corinne, Dunham, Steven A., Kuhn, Michael, Balthazar, Jacqueline T., Shafer, William M.
In Neisseria gonorrhoeae and Neisseria meningitidis, we identified a gene that would encode a protein highly similar to NorM of Vibrio parahaemolyticus (Y. Morita et al., Antimicrob. Agents...
Hertzig, Tobias, Weber, Martin, Greiffenberg, Lars, Holthausen, Britta Schulte, Goebel, Werner, Kim, Kwang Sik, ...
Listeria monocytogenes causes meningitis and encephalitis in humans and crosses the blood-brain barrier by yet unknown mechanisms. The interaction of the bacteria with different types of endothelial...
Pilgrim, Sabine, Kolb-Mäurer, Annette, Gentschev, Ivaylo, Goebel, Werner, Kuhn, Michael
Protein p60 encoded by the iap gene is regarded as an essential gene product of Listeria monocytogenes. Here we report, however, the successful construction of a viable iap deletion mutant of L....
Williams, Tatjana, Bauer, Susanne, Beier, Dagmar, Kuhn, Michael
Two-component systems are widely distributed in prokaryotes where they control gene expression in response to diverse stimuli. To study the role of the sixteen putative two-component systems of...
The paper inquires whether a public eco-label mitigatesadverse selection, where an ecologically superior (green) product variant is underprovided. A model, integrating entry into a perfectly...
Endogenous firm location is analyzed in a discrete two-region-two-firm model of product differentiation. In a non-cooperative game, two regional governments first decide on the imposition (or...
Low Quality Leadership in Vertically Differentiated Duopoly
According to the business literature a firm's competitive position is determined by the nature of the market. In a 'premium' market, profit leadership falls to firms of- fering high quality, whereas...
Direct-to-Consumer Advertising in Pharmaceutical Markets
We study effects of direct-to-consumer advertising (DTCA) in a mar- ket with two pharmaceutical firms providing horizontally dierentiated (branded) drugs. Patients varying in their susceptability to...
Delegating Budgets when Agents Care About Autonomy
We consider resource allocation within an organisation when agents have a preference for autonomy and show how delegation bears on moral hazard and adverse selection. Agents may care about autonomy...
Direct to Consumer Advertising in Pharmaceutical Markets
We study effects of direct-to-consumer advertising (DTCA) in the prescription drug market. There are two pharmaceutical firms providing horizontally differentiated (branded) drugs. Patients differ in...
Hauf, Nadja, Goebel, Werner, Fiedler, Franz, Sokolovic, Zeljka, Kuhn, Michael
As previously reported, Listeria monocytogenes infection of P388D1 macrophages results in a rapid induction of NF-κB DNA-binding activity. Here we show that this induction of NF-κB activity occurs...
Listeria Pathogenesis and Molecular Virulence Determinants
Vázquez-Boland, José A., Kuhn, Michael, Berche, Patrick, Chakraborty, Trinad, Domínguez-Bernal, Gustavo, Goebel, Werner, ...
The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and debilitated or...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Daniels, Justin, Kuhn, Michael
Internalization of Listeria monocytogenes into human brain microvascular endothelial cells (HBMEC) has recently been demonstrated to be dependent upon the inlB gene. In the present scanning electron...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Weiglein, Inge, Bubert, Andreas, Engelbrecht, Fredi, ...
Invasion of endothelial tissues may be crucial in a Listeria monocytogenes infection leading to meningitis and/or encephalitis. Internalization of L. monocytogenes into endothelial cells has been...
Rouquette-Loughlin, Corinne, Dunham, Steven A., Kuhn, Michael, Balthazar, Jacqueline T., Shafer, William M.
In Neisseria gonorrhoeae and Neisseria meningitidis, we identified a gene that would encode a protein highly similar to NorM of Vibrio parahaemolyticus (Y. Morita et al., Antimicrob. Agents...
Hertzig, Tobias, Weber, Martin, Greiffenberg, Lars, Holthausen, Britta Schulte, Goebel, Werner, Kim, Kwang Sik, ...
Listeria monocytogenes causes meningitis and encephalitis in humans and crosses the blood-brain barrier by yet unknown mechanisms. The interaction of the bacteria with different types of endothelial...
Pilgrim, Sabine, Kolb-Mäurer, Annette, Gentschev, Ivaylo, Goebel, Werner, Kuhn, Michael
Protein p60 encoded by the iap gene is regarded as an essential gene product of Listeria monocytogenes. Here we report, however, the successful construction of a viable iap deletion mutant of L....
Williams, Tatjana, Bauer, Susanne, Beier, Dagmar, Kuhn, Michael
Two-component systems are widely distributed in prokaryotes where they control gene expression in response to diverse stimuli. To study the role of the sixteen putative two-component systems of...
STRING 7—recent developments in the integration and prediction of protein interactions
Von Mering, Christian, Jensen, Lars J., Kuhn, Michael, Chaffron, Samuel, Doerks, Tobias, Krüger, Beate, ...
Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The...
Performance Indicators for Quality with Adverse Selection, Gaming and Inequality Aversion
Kuhn, Michael, Siciliani, Luigi
Performance indicators are increasingly used to regulate quality in health care and other areas of the public sector. We develop a model of contracting between a purchaser (principal) and a provider...
Delegating budgets when agents care about autonomy
We consider resource allocation within an organisation and show how delegation bears on moral hazard and adverse selection when agents have a preference for autonomy. Agents may care about autonomy...
Quality Monitoring, Collusion and Sub-contracting
We discuss the social welfare improvement under centralized and decentralized hierarchies and focus on supervisoris ability to monitor quality. Although the possibility of collusion against the...
STITCH: interaction networks of chemicals and proteins
Kuhn, Michael, Von Mering, Christian, Campillos, Monica, Jensen, Lars Juhl, Bork, Peer
The knowledge about interactions between proteins and small molecules is essential for the understanding of molecular and cellular functions. However, information on such interactions is widely...
SuperTarget and Matador: resources for exploring drug-target relationships
Günther, Stefan, Kuhn, Michael, Dunkel, Mathias, Campillos, Monica, Senger, Christian, Petsalaki, Evangelia, ...
The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of...
eggNOG: automated construction and annotation of orthologous groups of genes
Jensen, Lars Juhl, Julien, Philippe, Kuhn, Michael, Von Mering, Christian, Muller, Jean, Doerks, Tobias, ...
The identification of orthologous genes forms the basis for most comparative genomics studies. Existing approaches either lack functional annotation of the identified orthologous groups, hampering...
Upcoding and Optimal Auditing in Health Care (or The economics of DRG creep)
Kuhn, Michael, Siciliani, Luigi
We present a model of optimal contracting between a purchaser and a provider of health services. We assume that providers can increase demand by increasing quality but can also inflate activity...
Russell Mannion, Maria Goddard, Michael Kuhn, Angela Bate
Introduction: This article examines the incentive effects of delegating operational and financial decision making from central government to local healthcare providers. It addresses the economic...
Mauder, Norman, Williams, Tatjana, Fritsch, Frederike, Kuhn, Michael, Beier, Dagmar
We demonstrate that in Listeria monocytogenes, temperature-responsive transcriptional control of flagellar genes does not rely on the phosphorylation of the conserved phosphorylation site (D55) in...