Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here,...
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here,...