Michael H. Brodsky

Epigenetic telomere protection by Drosophila DNA damage response pathways (2006)

Oikemus, Sarah R., Queiroz-Machado, Joana, Lai, KuanJu, McGinnis-Schultz, Nadine, Sunkel, Claudio E., Brodsky, Michael H.

Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways (2006)

Sarah R. Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine McGinnis, Claudio Sunkel, Michael H. Brodsky

Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...

Epigenetic telomere protection by Drosophila DNA damage response pathways (2006)

Sarah R Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine M McGinnis, Claudio E. Sunkel, Michael H Brodsky

Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect (2004)

Oikemus, Sarah R., McGinnis-Schultz, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...

Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...

mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development

Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.

Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...

Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage

Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., McGinnis, Nadine M., Golic, Kent G., ...

We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent...

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect

Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...

Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...

A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors

Meng, Xiangdong, Brodsky, Michael H., Wolfe, Scot A.

The DNA-binding specificities of transcription factors can be used to computationally predict cis-regulatory modules (CRMs) that regulate gene expression1. However, the absence of specificity data...

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways

Oikemus, Sarah R, Queiroz-Machado, Joana, Lai, KuanJu, McGinnis, Nadine, Sunkel, Claudio, Brodsky, Michael H

Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...

mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development

Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.

Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...

Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage

Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., McGinnis, Nadine M., Golic, Kent G., ...

We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent...

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect

Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...

Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...

Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways

Oikemus, Sarah R, Queiroz-Machado, Joana, Lai, KuanJu, McGinnis, Nadine, Sunkel, Claudio, Brodsky, Michael H

Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...

A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system

Noyes, Marcus B., Meng, Xiangdong, Wakabayashi, Atsuya, Sinha, Saurabh, Brodsky, Michael H., Wolfe, Scot A.

Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis-regulatory modules in a genome. The primary...