Report to the Provost: Task Group on the Future of the Library (2007)
Grimes, Joseph, Halisky, Linda, Howard, Wayne H., Kearns, Timothy J., Kurfess, Franz J., Miller, Michael D., ...
The Provost's task group met Spring Quarter 2007 to examine the role of the library in support of the academic mission of Cal Poly. This document describes the areas of study and related...
The Shoah Foundation's Visual History: U-M's Access to the Holocaust (2005)
Carter, David, Gertel, Elliot, Llamas, Nerea A., Miller, Michael D.
In 1994, following the filming of Schindler's List, many survivors of the Nazi Holocaust came forward to offer their stories. Realizing that time was running out to document these personal histories,...
Campus Learning Spaces: Investing in How Students Learn (2005)
Acker, Stephen R., Miller, Michael D.
To justify the substantial investment in bricks-and-mortar construction, colleges and universities must design and continually renew the physical spaces in which students learn. A variety of research...
Weber, Jan, Chakraborty, Bikram, Weberova, Jitka, Miller, Michael D.
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutation K65R confers intermediate levels of resistance to several RT inhibitors, including a three- to fourfold...
Library-IT Partnerships: New Services for New Campus Demands (2004)
Acker, Stephen R., Miller, Michael D.
The roles of central information technology and library organizations are being transformed by demands that new campus services be delivered more effectively and efficiently. Both organizations have...
Army Air and Missile Defense. Future Challenges (2003)
Lussier, Frances M., Miller, Michael D., Nichiporuk, Brian, McGarvey, David C., Schwartz, Lowell
The Army must take steps today if it is to provide effective air and missile defenses against the threats that will emerge 20 years hence. Most analysts predict that the globalization of the economy...
Defense Industrial Planning for a Surge in Military Demand, (2002)
Baumbusch,Geneese G., Fleischauer,Patricia D., Harman,Alvin J., Miller,Michael D.
In the wake of post-Vietnam reductions in expenditures for military hardware, a concern arose that these reductions, together with certain supposedly perverse characteristics of defense business...
Measuring Technological Change in Jet Fighter Aircraft. (2002)
Stanley ,William L., Miller,Michael D.
This report develops technique to characterize level of and change in jet fighter air vehicle technology. It complements other methods used to assess technological risks of new fighter concepts and...
Thesis (M.S.H.I.)--University of Alabama at Birmingham, School of Health-Related Professions, 1999.
The Geometry of a Satellite-Ballistic Misile Engagement. (1998)
This note describes in mathematical terms the dynamic geometry between a constellation of satellites deployed for ballistic missile defense (BMD) and the missiles the satellites are engaging....
Quality Building Projects Through Constructability (1998)
In the future, customers of the construction industry will continue to demand projects that cost less, finish faster, and provide higher standards of quality. To meet these objectives, the...
Anticipating the Future: The University of Michigan's Media Union (1998)
The Media Union is a new facility that brings together information resources, information technology, and media production studios. It is unique in the blending of those resources into an integrated...
Noisy channel speech coder design for wireless applications /--by Michael D. Miller. (1998)
Thesis research directed by Dept. of Electrical Engineering.
Thesis (M.S.)--Michigan Technological University, 1996.
Typescript.
Thesis (B.Sc.) -- McMaster University, 1986.
Miller, Michael D., Marthas, Marta L., Margot, Nicolas A., Dailey, Peter J., Canfield, Don R., ...
Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing...
Retroviral cDNA Integration: Stimulation by HMG I Family Proteins
Li, Ling, Yoder, Kristine, Hansen, Mark S. T., Olvera, Jennifer, Miller, Michael D., Bushman, Frederic D.
To replicate, a retrovirus must synthesize a cDNA copy of the viral RNA genome and integrate that cDNA into a chromosome of the host. We have investigated the role of a host cell cofactor, HMG I(Y)...
Singer, Irwin I., Scott, Solomon, Kawka, Douglas W., Chin, Jayne, Daugherty, Bruce L., DeMartino, Julie A., ...
The chemokine receptors CCR5 and CXCR4 act synergistically with CD4 in an ordered multistep mechanism to allow the binding and entry of human immunodeficiency virus type 1 (HIV-1). The efficiency of...
Naeger, Lisa K., Margot, Nicolas A., Miller, Michael D.
Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase (RT) using ATP as an acceptor molecule has been proposed as a novel mechanism of...
White, Kirsten L., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Miller, Michael D., Naeger, Lisa K.
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in susceptibility to several nucleoside and nucleotide RT inhibitors....
Lineberger, Janet E., Danzeisen, Renee, Hazuda, Daria J., Simon, Adam J., Miller, Michael D.
Human immunodeficiency virus (HIV) entry into a host cell requires the fusion of virus and cellular membranes that is driven by interaction of the viral envelope glycoproteins gp120 and gp41...
Nef Does Not Affect the Efficiency of Human Immunodeficiency Virus Type 1 Fusion with Target Cells
Tobiume, Minoru, Lineberger, Janet E., Lundquist, Christopher A., Miller, Michael D., Aiken, Christopher
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef stimulates viral infectivity by an unknown mechanism. Recent studies have suggested that Nef may act by regulating the efficiency...
Delaney, William E., Yang, Huiling, Westland, Christopher E., Das, Kalyan, Arnold, Eddy, Gibbs, Craig S., ...
Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif...
White, Kirsten L., Chen, James M., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Naeger, Lisa K., ...
Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple...
Magierowska, Magdalena, Bernardin, Flavien, Garg, Seema, Staprans, Silvija, Miller, Michael D., ...
Antiviral tenofovir monotherapy was used to determine whether drug-selected simian immunodeficiency virus (SIV) variants replaced their wild-type progenitors at the same rate in different tissues of...
Wyma, Donald J., Jiang, Jiyang, Shi, Jiong, Zhou, Jing, Lineberger, Janet E., Miller, Michael D., ...
Retrovirus particles are not infectious until they undergo proteolytic maturation to form a functional core. Here we report a link between human immunodeficiency virus type 1 (HIV-1) core maturation...
Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, ...
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new mechanisms of action. Integrase, one of three viral enzymes essential...
Barnard, Richard J. O., Narayan, Shakti, Dornadula, Geethanjali, Miller, Michael D., Young, John A. T.
A novel entry mechanism has been proposed for the avian sarcoma and leukosis virus (ASLV), whereby interaction with specific cell surface receptors activates or primes the viral envelope glycoprotein...
Delaney, William E., Yang, Huiling, Miller, Michael D., Gibbs, Craig S., Xiong, Shelly
Combination therapies may be required for long-term management of some patients chronically infected with hepatitis B virus (HBV). Adefovir is a nucleotide analog that has similar activity against...
Murine T Cells Potently Restrict Human Immunodeficiency Virus Infection
Baumann, Jörg G., Unutmaz, Derya, Miller, Michael D., Breun, Sabine K. J., Grill, Stacy M., Mirro, Jane, ...
Development of a mouse model for human immunodeficiency virus type 1 (HIV-1) infection has advanced through the progressive identification of host cell factors required for HIV-1 replication. Murine...
Weber, Jan, Chakraborty, Bikram, Weberova, Jitka, Miller, Michael D., Quiñones-Mateu, Miguel E.
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutation K65R confers intermediate levels of resistance to several RT inhibitors, including a three- to fourfold...
Bianchi, Elisabetta, Finotto, Marco, Ingallinella, Paolo, Hrin, Renee, Carella, Anthony V., Hou, Xiaoli S., ...
Peptides from the N-heptad repeat region of the HIV gp41 protein can inhibit viral fusion, but their potency is limited by a low tendency to form a trimeric coiled-coil. Accordingly, stabilization of...
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope
Miller, Michael D., Geleziunas, Romas, Bianchi, Elisabetta, Lennard, Simon, Hrin, Renee, Zhang, Hangchun, ...
HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target...
Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus
Delaney, William E., Ray, Adrian S., Yang, Huiling, Qi, Xiaoping, Xiong, Shelly, Zhu, Yuao, ...
Tenofovir is an acyclic nucleotide analog with activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Tenofovir disoproxil fumarate (tenofovir DF), a bis-alkoxyester prodrug...
Miller, Michael D., Marthas, Marta L., Margot, Nicolas A., Dailey, Peter J., Canfield, Don R., ...
Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing...
Retroviral cDNA Integration: Stimulation by HMG I Family Proteins
Li, Ling, Yoder, Kristine, Hansen, Mark S. T., Olvera, Jennifer, Miller, Michael D., Bushman, Frederic D.
To replicate, a retrovirus must synthesize a cDNA copy of the viral RNA genome and integrate that cDNA into a chromosome of the host. We have investigated the role of a host cell cofactor, HMG I(Y)...
Singer, Irwin I., Scott, Solomon, Kawka, Douglas W., Chin, Jayne, Daugherty, Bruce L., DeMartino, Julie A., ...
The chemokine receptors CCR5 and CXCR4 act synergistically with CD4 in an ordered multistep mechanism to allow the binding and entry of human immunodeficiency virus type 1 (HIV-1). The efficiency of...
Naeger, Lisa K., Margot, Nicolas A., Miller, Michael D.
Removal of nucleoside chain terminator inhibitors mediated by human immunodeficiency virus (HIV) reverse transcriptase (RT) using ATP as an acceptor molecule has been proposed as a novel mechanism of...
White, Kirsten L., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Miller, Michael D., Naeger, Lisa K.
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in susceptibility to several nucleoside and nucleotide RT inhibitors....
Lineberger, Janet E., Danzeisen, Renee, Hazuda, Daria J., Simon, Adam J., Miller, Michael D.
Human immunodeficiency virus (HIV) entry into a host cell requires the fusion of virus and cellular membranes that is driven by interaction of the viral envelope glycoproteins gp120 and gp41...
Nef Does Not Affect the Efficiency of Human Immunodeficiency Virus Type 1 Fusion with Target Cells
Tobiume, Minoru, Lineberger, Janet E., Lundquist, Christopher A., Miller, Michael D., Aiken, Christopher
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef stimulates viral infectivity by an unknown mechanism. Recent studies have suggested that Nef may act by regulating the efficiency...
Delaney, William E., Yang, Huiling, Westland, Christopher E., Das, Kalyan, Arnold, Eddy, Gibbs, Craig S., ...
Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif...
White, Kirsten L., Chen, James M., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Naeger, Lisa K., ...
Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple...
Magierowska, Magdalena, Bernardin, Flavien, Garg, Seema, Staprans, Silvija, Miller, Michael D., ...
Antiviral tenofovir monotherapy was used to determine whether drug-selected simian immunodeficiency virus (SIV) variants replaced their wild-type progenitors at the same rate in different tissues of...
Wyma, Donald J., Jiang, Jiyang, Shi, Jiong, Zhou, Jing, Lineberger, Janet E., Miller, Michael D., ...
Retrovirus particles are not infectious until they undergo proteolytic maturation to form a functional core. Here we report a link between human immunodeficiency virus type 1 (HIV-1) core maturation...
Hazuda, Daria J., Anthony, Neville J., Gomez, Robert P., Jolly, Samson M., Wai, John S., Zhuang, Linghang, ...
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new mechanisms of action. Integrase, one of three viral enzymes essential...
Barnard, Richard J. O., Narayan, Shakti, Dornadula, Geethanjali, Miller, Michael D., Young, John A. T.
A novel entry mechanism has been proposed for the avian sarcoma and leukosis virus (ASLV), whereby interaction with specific cell surface receptors activates or primes the viral envelope glycoprotein...
Delaney, William E., Yang, Huiling, Miller, Michael D., Gibbs, Craig S., Xiong, Shelly
Combination therapies may be required for long-term management of some patients chronically infected with hepatitis B virus (HBV). Adefovir is a nucleotide analog that has similar activity against...
Murine T Cells Potently Restrict Human Immunodeficiency Virus Infection
Baumann, Jörg G., Unutmaz, Derya, Miller, Michael D., Breun, Sabine K. J., Grill, Stacy M., Mirro, Jane, ...
Development of a mouse model for human immunodeficiency virus type 1 (HIV-1) infection has advanced through the progressive identification of host cell factors required for HIV-1 replication. Murine...
Weber, Jan, Chakraborty, Bikram, Weberova, Jitka, Miller, Michael D., Quiñones-Mateu, Miguel E.
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutation K65R confers intermediate levels of resistance to several RT inhibitors, including a three- to fourfold...
Bianchi, Elisabetta, Finotto, Marco, Ingallinella, Paolo, Hrin, Renee, Carella, Anthony V., Hou, Xiaoli S., ...
Peptides from the N-heptad repeat region of the HIV gp41 protein can inhibit viral fusion, but their potency is limited by a low tendency to form a trimeric coiled-coil. Accordingly, stabilization of...
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope
Miller, Michael D., Geleziunas, Romas, Bianchi, Elisabetta, Lennard, Simon, Hrin, Renee, Zhang, Hangchun, ...
HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target...
Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus
Delaney, William E., Ray, Adrian S., Yang, Huiling, Qi, Xiaoping, Xiong, Shelly, Zhu, Yuao, ...
Tenofovir is an acyclic nucleotide analog with activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Tenofovir disoproxil fumarate (tenofovir DF), a bis-alkoxyester prodrug...
Svarovskaia, Evguenia S., Moser, Michael J., Bae, Andrew S., Prudent, James R., Miller, Michael D., Borroto-Esoda, Katyna
We report a real-time PCR assay capable of detecting drug-resistant human immunodeficiency virus type 1 reverse transcriptase K65R mutant virus at a level of 0.5% in polymorphic patient plasma...
Marchand, Bruno, White, Kirsten L., Ly, John K., Margot, Nicolas A., Wang, Ruth, McDermott, Martin, ...
The ATP-dependent phosphorolytic excision of nucleoside analogue reverse transcriptase inhibitors can diminish their inhibitory effects on human immunodeficiency virus replication. Previous studies...
In Vitro Drug Susceptibility Analysis of Hepatitis B Virus Clinical Quasispecies Populations▿
Zhu, Yuao, Curtis, Maria, Snow-Lampart, Andrea, Yang, Huiling, Delaney, William, Miller, Michael D., ...
Analysis of the replication and drug resistance of patient serum hepatitis B virus (HBV) populations can contribute to the therapeutic management of chronic hepatitis B. We developed a procedure for...
Gordon, Shari N., Dunham, Richard M., Engram, Jessica C., Estes, Jacob, Wang, Zichun, Klatt, Nichole R., ...
Sooty mangabeys (SMs) naturally infected with simian immunodeficiency virus (SIV) do not develop AIDS despite high levels of virus replication. At present, the mechanisms underlying this disease...
Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys▿
Pandrea, Ivona, Ribeiro, Ruy M., Gautam, Rajeev, Gaufin, Thaidra, Pattison, Melissa, Barnes, Mary, ...
The mechanisms underlying the lack of disease progression in natural simian immunodeficiency virus (SIV) hosts are still poorly understood. To test the hypothesis that SIV-infected African green...