Michael B. Hovater

Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals

Hovater, Michael B., Olteanu, Dragos, Hanson, Elizabeth L., Cheng, Nai-Lin, Siroky, Brian, Fintha, Attila, ...

Renal epithelial cells release ATP constitutively under basal conditions and release higher quantities of purine nucleotide in response to stimuli. ATP filtered at the glomerulus, secreted by...

Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts

Hovater, Michael B., Olteanu, Dragos, Welty, Elisabeth A., Schwiebert, Erik M.

The nephron is the functional unit of the kidney. Blood and plasma are continually filtered within the glomeruli that begin each nephron. Adenosine 5′ triphosphate (ATP) and its metabolites are...