Michael A. Watson

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...

The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

Goodwin, Bryan, Gauthier, Karine C., Umetani, Michihisa, Watson, Michael A., Lochansky, Matthew I., Collins, Jon L., ...

Sterol 27-hydroxylase (CYP27A1) is required for bile acid synthesis by both the classical and alternate pathways. Cyp27a1−/− mice exhibit a dramatic increase in the activity of cytochrome P450 3A...

Genogroup I and II Noroviruses Detected in Stool Samples by Real-Time Reverse Transcription-PCR Using Highly Degenerate Universal Primers

Richards, Gary P., Watson, Michael A., Fankhauser, Rebecca L., Monroe, Stephan S.

Genogroup I noroviruses from five genetic clusters and genogroup II noroviruses from eight genetic clusters were detected in stool extracts using degenerate primers and single-tube, real-time reverse...

Development of a Simple and Rapid Fluorogenic Procedure for Identification of Vibrionaceae Family Members

Richards, Gary P., Watson, Michael A., Parveen, Salina

We describe a simple colony overlay procedure for peptidases (COPP) for the rapid fluorogenic detection and quantification of Vibrionaceae from seawater, shellfish, sewage, and clinical samples. The...

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...

The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

Goodwin, Bryan, Gauthier, Karine C., Umetani, Michihisa, Watson, Michael A., Lochansky, Matthew I., Collins, Jon L., ...

Sterol 27-hydroxylase (CYP27A1) is required for bile acid synthesis by both the classical and alternate pathways. Cyp27a1−/− mice exhibit a dramatic increase in the activity of cytochrome P450 3A...

Genogroup I and II Noroviruses Detected in Stool Samples by Real-Time Reverse Transcription-PCR Using Highly Degenerate Universal Primers

Richards, Gary P., Watson, Michael A., Fankhauser, Rebecca L., Monroe, Stephan S.

Genogroup I noroviruses from five genetic clusters and genogroup II noroviruses from eight genetic clusters were detected in stool extracts using degenerate primers and single-tube, real-time reverse...

Development of a Simple and Rapid Fluorogenic Procedure for Identification of Vibrionaceae Family Members

Richards, Gary P., Watson, Michael A., Parveen, Salina

We describe a simple colony overlay procedure for peptidases (COPP) for the rapid fluorogenic detection and quantification of Vibrionaceae from seawater, shellfish, sewage, and clinical samples. The...

Shewanella and Photobacterium spp. in Oysters and Seawater from the Delaware Bay▿

Richards, Gary P., Watson, Michael A., Crane, Edward J., Burt, Iris G., Bushek, David

Shewanella algae, S. putrefaciens, and Photobacterium damselae subsp. damselae are indigenous marine bacteria and human pathogens causing cellulitis, necrotizing fasciitis, abscesses, septicemia, and...