Population genomics of domestic and wild yeasts (2008)
David M. Carter, Gianni Liti, Alan M. Moses, Leopold Parts, Stephen A. James, Robert P. Davey, ...
The natural genetics of an organism is determined by the distribution of sequences of its genome. Here we present one- to four-fold, with some deeper, coverage of the genome sequences of over seventy...
Crossman, Lisa C, Gould, Virginia C, Dow, J Maxwell, Vernikos, Georgios S, Okazaki, Aki, Sebaihia, Mohammed, ...
Abstract Background Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to...
Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates. (2008)
Thomson, Nicholas R., Holden, .Matthew T.G., Carder, C.Caroline, Lennard, Nicola, Lockey, Sarah J., Marsh, Pete, ...
Chlamydia trachomatis is the most common cause of sexually transmitted infections in the UK, a statistic that is also reflected globally. There are three biovariants of C. trachomatis: trachoma...
Stephen D. Bentley, George S. Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Bentley, Stephen D., Vernikos, George S., Snyder, Lori A. S., Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Nicholas R. Thomson, Sarah Howard, Brendan W. Wren, Lisa Crossman, Gregory L. Challis, ...
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...
Stephen D. Bentley, George Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...
The bacterium, Neisseria meningitidis, is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Phylogenetic Relationships of the Wolbachia of Nematodes and Arthropods (2006)
Katelyn Fenn, Claire Conlon, Martin Jones, Michael A. Quail, Nancy E. Holroyd, Julian Parkhill, ...
Wolbachia are well known as bacterial symbionts of arthropods, where they are reproductive parasites, but have also been described from nematode hosts, where the symbiotic interaction has features of...
The genome of Rhizobium leguminosarumhas recognizable core and accessory components (2006)
Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...
Abstract Background Rhizobium leguminosarum is an α-proteobacterial N 2 -fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic...
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes (2006)
Stephen D. Bentley, David M. Aanensen, Angeliki Mavroidi, David Saunders, Ester Rabbinowitsch, Matthew Collins, ...
Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...
Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria (2005)
Peter C. Bull, Matthew Berriman, Sue Kyes, Michael A. Quail, Neil Hall, Moses M. Kortok, ...
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
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Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei (2004)
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeno-Tarraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Hall, Neil, Berriman, Matthew, Lennard, Nicola J., Harris, Barbara R., Hertz-Fowler, Christiane, Bart-Delabesse, Emmanuelle N., ...
The African trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa. Here we report the sequence and analysis of the 1.1 Mb chromosome I, which encodes approximately...
Parkhill, Julian, Sebaihia, Mohammed, Preston, Andrew, Murphy, Lee D., Thomson, Nicholas, Harris, David E., ...
Berry, Colin, O'Neil, Susan, Ben-Dov, Eitan, Jones, Andrew F., Murphy, Lee, Quail, Michael A., ...
The entire 127,923-bp sequence of the toxin-encoding plasmid pBtoxis from Bacillus thuringiensis subsp. israelensis is presented and analyzed. In addition to the four known Cry and two known Cyt...
Hall, Neil, Berriman, Matthew, Lennard, Nicola J., Harris, Barbara R., Hertz-Fowler, Christiane, Bart-Delabesse, Emmanuelle N., ...
The African trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa. Here we report the sequence and analysis of the 1.1 Mb chromosome I, which encodes approximately...
Short-Insert Libraries as a Method of Problem Solving in Genome Sequencing
McMurray, Amanda A., Sulston, John E., Quail, Michael A.
As the Human Genome Project moves into its sequencing phase, a serious problem has arisen. The same problem has been increasingly vexing in the closing phase of the Caenorhabditis elegans project....
The Complex Repeats of Dictyostelium discoideum
Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...
In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...
The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...
Armstrong, Miles R., Whisson, Stephen C., Pritchard, Leighton, Bos, Jorunn I. B., Venter, Eduard, Avrova, Anna O., ...
The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847. It represents a reemerging threat to potato production and is one of...
The pCoo Plasmid of Enterotoxigenic Escherichia coli Is a Mosaic Cointegrate†
Froehlich, Barbara, Parkhill, Julian, Sanders, Mandy, Quail, Michael A., Scott, June R.
CS1 is the prototype of a class of pili of enterotoxigenic Escherichia coli (ETEC) associated with diarrheal disease in humans. The genes encoding this pilus are carried on a large plasmid, pCoo. We...
Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
Bull, Peter C, Berriman, Matthew, Kyes, Sue, Quail, Michael A, Hall, Neil, Kortok, Moses M, ...
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var...
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes
Bentley, Stephen D, Aanensen, David M, Mavroidi, Angeliki, Saunders, David, Rabbinowitsch, Ester, Collins, Matthew, ...
Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...
The Genome of the Kinetoplastid Parasite, Leishmania major
Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, ...
The genome of Rhizobium leguminosarum has recognizable core and accessory components
Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...
The genome sequence of the α-proteobacterial N2-fixing symbiont of legumes, Rhizobium leguminosarum, is described, revealing a 'core' and an 'accessory' component.
Gene Arrays at Pneumocystis carinii Telomeres
Keely, Scott P., Renauld, Hubert, Wakefield, Ann E., Cushion, Melanie T., Smulian, A. George, Fosker, Nigel, ...
In the fungus Pneumocystis carinii, at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antigenic variation, which is likely to be a strategy by which this...
Phylogenetic Relationships of the Wolbachia of Nematodes and Arthropods
Fenn, Katelyn, Conlon, Claire, Jones, Martin, Quail, Michael A, Holroyd, Nancy E, Parkhill, Julian, ...
Wolbachia are well known as bacterial symbionts of arthropods, where they are reproductive parasites, but have also been described from nematode hosts, where the symbiotic interaction has features of...
Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...
Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...
Berry, Colin, O'Neil, Susan, Ben-Dov, Eitan, Jones, Andrew F., Murphy, Lee, Quail, Michael A., ...
The entire 127,923-bp sequence of the toxin-encoding plasmid pBtoxis from Bacillus thuringiensis subsp. israelensis is presented and analyzed. In addition to the four known Cry and two known Cyt...
Hall, Neil, Berriman, Matthew, Lennard, Nicola J., Harris, Barbara R., Hertz-Fowler, Christiane, Bart-Delabesse, Emmanuelle N., ...
The African trypanosome, Trypanosoma brucei, causes sleeping sickness in humans in sub-Saharan Africa. Here we report the sequence and analysis of the 1.1 Mb chromosome I, which encodes approximately...
Short-Insert Libraries as a Method of Problem Solving in Genome Sequencing
McMurray, Amanda A., Sulston, John E., Quail, Michael A.
As the Human Genome Project moves into its sequencing phase, a serious problem has arisen. The same problem has been increasingly vexing in the closing phase of the Caenorhabditis elegans project....
The Complex Repeats of Dictyostelium discoideum
Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...
In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....
Liu, Minghsun, Gingery, Mari, Doulatov, Sergei R., Liu, Yichin, Hodes, Asher, Baker, Stephen, ...
Liu et al. recently described a group of related temperate bacteriophages that infect Bordetella subspecies and undergo a unique template-dependent, reverse transcriptase-mediated tropism switching...
Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...
Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...
Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...
Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...
The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...
Armstrong, Miles R., Whisson, Stephen C., Pritchard, Leighton, Bos, Jorunn I. B., Venter, Eduard, Avrova, Anna O., ...
The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847. It represents a reemerging threat to potato production and is one of...
The pCoo Plasmid of Enterotoxigenic Escherichia coli Is a Mosaic Cointegrate†
Froehlich, Barbara, Parkhill, Julian, Sanders, Mandy, Quail, Michael A., Scott, June R.
CS1 is the prototype of a class of pili of enterotoxigenic Escherichia coli (ETEC) associated with diarrheal disease in humans. The genes encoding this pilus are carried on a large plasmid, pCoo. We...
Plasmodium falciparum Variant Surface Antigen Expression Patterns during Malaria
Bull, Peter C, Berriman, Matthew, Kyes, Sue, Quail, Michael A, Hall, Neil, Kortok, Moses M, ...
The variant surface antigens expressed on Plasmodium falciparum–infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var...
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes
Bentley, Stephen D, Aanensen, David M, Mavroidi, Angeliki, Saunders, David, Rabbinowitsch, Ester, Collins, Matthew, ...
Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...
Gene Arrays at Pneumocystis carinii Telomeres
Keely, Scott P., Renauld, Hubert, Wakefield, Ann E., Cushion, Melanie T., Smulian, A. George, Fosker, Nigel, ...
In the fungus Pneumocystis carinii, at least three gene families (PRT1, MSR, and MSG) have the potential to generate high-frequency antigenic variation, which is likely to be a strategy by which this...
Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...
Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...
The genome of Rhizobium leguminosarum has recognizable core and accessory components
Young, J Peter W, Crossman, Lisa C, Johnston, Andrew WB, Thomson, Nicholas R, Ghazoui, Zara F, Hull, Katherine H, ...
The genome sequence of the α-proteobacterial N2-fixing symbiont of legumes, Rhizobium leguminosarum, is described, revealing a 'core' and an 'accessory' component.
Phylogenetic Relationships of the Wolbachia of Nematodes and Arthropods
Fenn, Katelyn, Conlon, Claire, Jones, Martin, Quail, Michael A, Holroyd, Nancy E, Parkhill, Julian, ...
Wolbachia are well known as bacterial symbionts of arthropods, where they are reproductive parasites, but have also been described from nematode hosts, where the symbiotic interaction has features of...
Thomson, Nicholas R, Howard, Sarah, Wren, Brendan W, Holden, Matthew T. G, Crossman, Lisa, Challis, Gregory L, ...
The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is...
Bentley, Stephen D, Vernikos, George S, Snyder, Lori A. S, Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...
The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii
Khan, Asis, Böhme, Ulrike, Kelly, Krystyna A., Adlem, Ellen, Brooks, Karen, Simmonds, Mark, ...
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has...
Holden, Matthew T. G., Scott, Annabel, Cherevach, Inna, Chillingworth, Tracey, Churcher, Carol, Cronin, Ann, ...
Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the...
Holt, Kathryn E., Thomson, Nicholas R., Wain, John, Phan, Minh Duy, Nair, Satheesh, Hasan, Rumina, ...
Salmonella enterica serovars Typhi and Paratyphi A cause systemic infections in humans which are referred to as enteric fever. Multidrug-resistant (MDR) serovar Typhi isolates emerged in the 1980s,...
Genome plasticity of BCG and impact on vaccine efficacy
Brosch, Roland, Gordon, Stephen V., Garnier, Thierry, Eiglmeier, Karin, Frigui, Wafa, Valenti, Philippe, ...
To understand the evolution, attenuation, and variable protective efficacy of bacillus Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected to comparative...
Sebaihia, Mohammed, Peck, Michael W., Minton, Nigel P., Thomson, Nicholas R., Holden, Matthew T.G., Mitchell, Wilfrid J., ...
Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin,...