Scientific Commons: Michael A. Jarvis

A protein-based therapeutic for human cytomegalovirus infection

Jean, François, Thomas, Laurel, Molloy, Sean S., Liu, Gseping, Jarvis, Michael A., Nelson, Jay A., ...

Current antiviral strategies target viral gene products. Although initially successful, their severe toxicity and susceptibility to circumvention by the generation of drug-resistant variants limit...

Human Cytomegalovirus Infection of Caco-2 Cells Occurs at the Basolateral Membrane and Is Differentiation State Dependent

Jarvis, Michael A., Wang, C. Edward, Meyers, Heather L., Smith, Patricia P., Corless, Christopher L., Henderson, Gavin J., ...

Epithelial cells are known to be a major target for human cytomegalovirus (HCMV) infection; however, the analysis of virus-cell interactions has been difficult to approach due to the lack of in vitro...

Retrieval of Human Cytomegalovirus Glycoprotein B from Cell Surface Is Not Required for Virus Envelopment in Astrocytoma Cells

Jarvis, Michael A., Fish, Kenneth N., Söderberg-Naucler, Cecilia, Streblow, Daniel N., Meyers, Heather L., Thomas, Gary, ...

Human cytomegalovirus (HCMV) is a prototypic member of the betaherpesvirus family. The HCMV virion is composed of a large DNA genome encapsidated within a nucleocapsid, which is wrapped within an...

Coding potential of laboratory and clinical strains of human cytomegalovirus

Murphy, Eain, Yu, Dong, Grimwood, Jane, Schmutz, Jeremy, Dickson, Mark, Jarvis, Michael A., ...

Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have...

Phosphorylation of Human Cytomegalovirus Glycoprotein B (gB) at the Acidic Cluster Casein Kinase 2 Site (Ser900) Is Required for Localization of gB to the trans-Golgi Network and Efficient Virus Replication

Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., ...

Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified...

A Cyclooxygenase-2 Homologue Encoded by Rhesus Cytomegalovirus Is a Determinant for Endothelial Cell Tropism

Rue, Cary A., Jarvis, Michael A., Knoche, Amber J., Meyers, Heather L., DeFilippis, Victor R., Hansen, Scott G., ...

Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that mediates the synthesis of prostaglandins from arachidonic acid. The eicosanoids function as critical regulators...

Antigenic Domain 1 Is Required for Oligomerization of Human Cytomegalovirus Glycoprotein B

Britt, William J., Jarvis, Michael A., Drummond, Derek D., Mach, Michael

Human cytomegalovirus (HCMV) glycoprotein B (gB) is an abundant virion envelope protein that has been shown to be essential for the infectivity of HCMV. HCMV gB is also one of the most immunogenic...

Human Cytomegalovirus Entry into Epithelial and Endothelial Cells Depends on Genes UL128 to UL150 and Occurs by Endocytosis and Low-pH Fusion

Ryckman, Brent J., Jarvis, Michael A, Drummond, Derek D., Nelson, Jay A., Johnson, David C.

Human cytomegalovirus (HCMV) replication in epithelial and endothelial cells appears to be important in virus spread, disease, and persistence. It has been difficult to study infection of these cell...

Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kit Proto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

Moses, Ashlee V., Jarvis, Michael A., Raggo, Camilo, Bell, Yolanda C., Ruhl, Rebecca, Luukkonen, B. G. Mattias, ...

Kaposi's sarcoma (KS), the most frequent malignancy afflicting AIDS patients, is characterized by spindle cell formation and vascularization. Infection with KS-associated herpesvirus (KSHV) is...

Human Cytomegalovirus Attenuates Interleukin-1β and Tumor Necrosis Factor Alpha Proinflammatory Signaling by Inhibition of NF-κB Activation

Jarvis, Michael A., Borton, Jamie A., Keech, Amy M., Wong, John, Britt, William J., Magun, Bruce E., ...

Viral infection is associated with a vigorous inflammatory response characterized by cellular infiltration and release of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor...