Maya K. Leabman

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., De La Cruz, Melanie, ...

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug...

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, ...

The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted...

Functional genomics of membrane transporters in human populations

Urban, Thomas J., Sebro, Ronnie, Hurowitz, Evan H., Leabman, Maya K., Badagnani, Ilaria, Lagpacan, Leah L., ...

Although considerable progress has been made toward characterizing human DNA sequence variation, there remains a deficiency in information on human phenotypic variation at the single-gene level. We...

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., De La Cruz, Melanie, ...

Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug...

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, ...

The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted...

Functional genomics of membrane transporters in human populations

Urban, Thomas J., Sebro, Ronnie, Hurowitz, Evan H., Leabman, Maya K., Badagnani, Ilaria, Lagpacan, Leah L., ...

Although considerable progress has been made toward characterizing human DNA sequence variation, there remains a deficiency in information on human phenotypic variation at the single-gene level. We...