Cell-type specific gene expression profiles of leukocytes in human peripheral blood (2006)
Palmer, Chana, Diehn, Maximilian, Alizadeh, Ash A, Brown, Patrick O
Abstract Background Blood is a complex tissue comprising numerous cell types with distinct functions and corresponding gene expression profiles. We attempted to define the cell type specific gene...
Genome-Scale Identification of Membrane-Associated Human mRNAs (2006)
Maximilian Diehn, Ramona Bhattacharya, David Botstein, Patrick O. Brown
The subcellular localization of proteins is critical to their biological roles. Moreover, whether a protein is membrane-bound, secreted, or intracellular affects the usefulness of, and the strategies...
Differential gene expression in anatomical compartments of the human eye (2005)
Diehn, Jennifer J, Diehn, Maximilian, Marmor, Michael F, Brown, Patrick O
Abstract Background The human eye is composed of multiple compartments, diverse in form, function, and embryologic origin, that work in concert to provide us with our sense of sight. We set out to...
A method for detecting and correcting feature misidentification on expression microarrays (2004)
Tu, I-Ping, Schaner, Marci, Diehn, Maximilian, Sikic, Branimir I, Brown, Patrick O, Botstein, David, ...
Abstract Background Much of the microarray data published at Stanford is based on mouse and human arrays produced under controlled and monitored conditions at the Brown and Botstein laboratories and...
Diehn, Maximilian., Brown, Patrick O. Advisor
Submitted to the Program in Biophysics.
Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
In the absence of basal signaling, RAG activity is high at a time during T cell development when it is otherwise normally suppressed.
Jeroen P. Roose, Maximilian Diehn, Michael G. Tomlinson, Joseph Lin, Ash A. Alizadeh, David Botstein, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Transcriptional programs activated by exposure of human prostate cancer cells to androgen (2002)
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
Abstract Background Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal...
Sayama, Koichi, Diehn, Maximilian, Matsuda, Kentaro, Lunderius, Carolina, Tsai, Mindy, Tam, See-Ying, ...
Abstract Background In asthma and other allergic disorders, the activation of mast cells by IgE and antigen induces the cells to release histamine and other mediators of inflammation, as well as to...
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade (2000)
Bunnell, Stephen C., Diehn, Maximilian, Yaffe, Michael B., Findell, Paul R., Cantley, Lewis C., Berg, Leslie J.
Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3'-kinase to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-regulated...
Sayama, Koichi, Diehn, Maximilian, Matsuda, Kentaro, Lunderius, Carolina, Tsai, Mindy, Tam, See-Ying, ...
Stereotyped and specific gene expression programs in human innate immune responses to bacteria
Boldrick, Jennifer C., Alizadeh, Ash A., Diehn, Maximilian, Dudoit, Sandrine, Liu, Chih Long, Belcher, Christopher E., ...
The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene...
Lossos, Izidore S., Alizadeh, Ash A., Diehn, Maximilian, Warnke, Roger, Thorstenson, Yvonne, Oefner, Peter J., ...
The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene-expression profiles...
Transcriptional programs activated by exposure of human prostate cancer cells to androgen
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
DNA microarrays were used to examine the temporal program of gene expression following treatment of a human prostate cancer cell line with androgen. Significant changes in levels of transcripts of...
Diehn, Maximilian, Alizadeh, Ash A., Rando, Oliver J., Liu, Chih Long, Stankunas, Kryn, Botstein, David, ...
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic...
Individuality and variation in gene expression patterns in human blood
Whitney, Adeline R., Diehn, Maximilian, Popper, Stephen J., Alizadeh, Ash A., Boldrick, Jennifer C., Relman, David A., ...
The nature and extent of interindividual and temporal variation in gene expression patterns in specific cells and tissues is an important and relatively unexplored issue in human biology. We surveyed...
SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data
Diehn, Maximilian, Sherlock, Gavin, Binkley, Gail, Jin, Heng, Matese, John C., Hernandez-Boussard, Tina, ...
The explosion in the number of functional genomic datasets generated with tools such as DNA microarrays has created a critical need for resources that facilitate the interpretation of large-scale...
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Gene Expression Patterns in Ovarian Carcinomas
Schaner, Marci E., Ross, Douglas T., Ciaravino, Giuseppe, Sørlie, Therese, Troyanskaya, Olga, Diehn, Maximilian, ...
We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from...
A method for detecting and correcting feature misidentification on expression microarrays
Tu, I-Ping, Schaner, Marci, Diehn, Maximilian, Sikic, Branimir I, Brown, Patrick O, Botstein, David, ...
Differential gene expression in anatomical compartments of the human eye
Diehn, Jennifer J, Diehn, Maximilian, Marmor, Michael F, Brown, Patrick O
DNA microarrays (representing approximately 30,000 human genes) were used to analyze gene expression in six different human eye compartments, revealing candidate genes for diseases affecting the...
Genome-Scale Identification of Membrane-Associated Human mRNAs
Diehn, Maximilian, Bhattacharya, Ramona, Botstein, David, Brown, Patrick O
The subcellular localization of proteins is critical to their biological roles. Moreover, whether a protein is membrane-bound, secreted, or intracellular affects the usefulness of, and the strategies...
In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone
Clément, Karine, Viguerie, Nathalie, Diehn, Maximilian, Alizadeh, Ash, Barbe, Pierre, Thalamas, Claire, ...
Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss....
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Palmer, Chana, Diehn, Maximilian, Alizadeh, Ash A, Brown, Patrick O
Sayama, Koichi, Diehn, Maximilian, Matsuda, Kentaro, Lunderius, Carolina, Tsai, Mindy, Tam, See-Ying, ...
Stereotyped and specific gene expression programs in human innate immune responses to bacteria
Boldrick, Jennifer C., Alizadeh, Ash A., Diehn, Maximilian, Dudoit, Sandrine, Liu, Chih Long, Belcher, Christopher E., ...
The innate immune response is crucial for defense against microbial pathogens. To investigate the molecular choreography of this response, we carried out a systematic examination of the gene...
Lossos, Izidore S., Alizadeh, Ash A., Diehn, Maximilian, Warnke, Roger, Thorstenson, Yvonne, Oefner, Peter J., ...
The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large B cell lymphoma (DLBCL). We compared the gene-expression profiles...
Transcriptional programs activated by exposure of human prostate cancer cells to androgen
DePrimo, Samuel E, Diehn, Maximilian, Nelson, Joel B, Reiter, Robert E, Matese, John, Fero, Mike, ...
DNA microarrays were used to examine the temporal program of gene expression following treatment of a human prostate cancer cell line with androgen. Significant changes in levels of transcripts of...
Diehn, Maximilian, Alizadeh, Ash A., Rando, Oliver J., Liu, Chih Long, Stankunas, Kryn, Botstein, David, ...
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic...
Individuality and variation in gene expression patterns in human blood
Whitney, Adeline R., Diehn, Maximilian, Popper, Stephen J., Alizadeh, Ash A., Boldrick, Jennifer C., Relman, David A., ...
The nature and extent of interindividual and temporal variation in gene expression patterns in specific cells and tissues is an important and relatively unexplored issue in human biology. We surveyed...
In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone
Clément, Karine, Viguerie, Nathalie, Diehn, Maximilian, Alizadeh, Ash, Barbe, Pierre, Thalamas, Claire, ...
Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss....
SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data
Diehn, Maximilian, Sherlock, Gavin, Binkley, Gail, Jin, Heng, Matese, John C., Hernandez-Boussard, Tina, ...
The explosion in the number of functional genomic datasets generated with tools such as DNA microarrays has created a critical need for resources that facilitate the interpretation of large-scale...
T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression
Roose, Jeroen P, Diehn, Maximilian, Tomlinson, Michael G, Lin, Joseph, Alizadeh, Ash A, Botstein, David, ...
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and...
Gene Expression Patterns in Ovarian Carcinomas
Schaner, Marci E., Ross, Douglas T., Ciaravino, Giuseppe, Sørlie, Therese, Troyanskaya, Olga, Diehn, Maximilian, ...
We used DNA microarrays to characterize the global gene expression patterns in surface epithelial cancers of the ovary. We identified groups of genes that distinguished the clear cell subtype from...
A method for detecting and correcting feature misidentification on expression microarrays
Tu, I-Ping, Schaner, Marci, Diehn, Maximilian, Sikic, Branimir I, Brown, Patrick O, Botstein, David, ...
Liang, Yu, Diehn, Maximilian, Watson, Nathan, Bollen, Andrew W., Aldape, Ken D., Nicholas, M. Kelly, ...
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We...
Differential gene expression in anatomical compartments of the human eye
Diehn, Jennifer J, Diehn, Maximilian, Marmor, Michael F, Brown, Patrick O
DNA microarrays (representing approximately 30,000 human genes) were used to analyze gene expression in six different human eye compartments, revealing candidate genes for diseases affecting the...
Genome-Scale Identification of Membrane-Associated Human mRNAs
Diehn, Maximilian, Bhattacharya, Ramona, Botstein, David, Brown, Patrick O
The subcellular localization of proteins is critical to their biological roles. Moreover, whether a protein is membrane-bound, secreted, or intracellular affects the usefulness of, and the strategies...
Cell-type specific gene expression profiles of leukocytes in human peripheral blood
Palmer, Chana, Diehn, Maximilian, Alizadeh, Ash A, Brown, Patrick O
Identification of noninvasive imaging surrogates for brain tumor gene-expression modules
Diehn, Maximilian, Nardini, Christine, Wang, David S., McGovern, Susan, Jayaraman, Mahesh, Liang, Yu, ...
Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. We combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression...