Preuss, Mirjam AR, Faber, Marie-Luise, Tan, Gene S, Dietzschold, Bernhard, Schnell, Matthias J, Weihe, Eberhard
No abstract available.
Recombinant rabies virus as potential live-viral vaccines for HIV-1
Schnell, Matthias J., Foley, Heather D., Siler, Catherine A., McGettigan, James P., Dietzschold, Bernhard, Pomerantz, Roger J.
Recombinant, replication-competent rabies virus (RV) vaccine strain-based vectors were developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a laboratory-adapted...
Foley, Heather D., McGettigan, James P., Siler, Catherine A., Dietzschold, Bernhard, Schnell, Matthias J.
To investigate the importance of the rabies virus (RV) glycoprotein (G) in protection against rabies, we constructed a recombinant RV (rRV) in which the RV G ecto- and transmembrane domains were...
Kim, Sung-Kwon, Reed, Douglas S., Olson, Sara, Schnell, Matthias J., Rose, John K., Morton, Phillip A., ...
We compared peripheral and mucosal primary CD8 T cell responses to inflammatory and noninflammatory forms of antigen in a T cell-adoptive transfer system. Immunization with the soluble antigen,...
McGettigan, James P., Foley, Heather D., Belyakov, Igor M., Berzofsky, Jay A., Pomerantz, Roger J., Schnell, Matthias J.
Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for human immunodeficiency virus type 1 (HIV-1) infection. Our previous...
Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction
Harty, Ronald N., Brown, Melissa E., McGettigan, James P., Wang, Guangli, Jayakar, Himangi R., Huibregtse, Jon M., ...
The matrix (M) proteins of vesicular stomatitis virus (VSV) and rabies virus (RV) play a key role in both assembly and budding of progeny virions. A PPPY motif (PY motif or late-budding domain) is...
Pulmanausahakul, Rojjanaporn, Faber, Milosz, Morimoto, Kinjiro, Spitsin, Sergei, Weihe, Eberhard, Hooper, D. Craig, ...
The pathogenicity of individual rabies virus strains appears to correlate inversely with the extent of apoptotic cell death they induce and with the expression of rabies virus glycoprotein, a major...
McGettigan, James P., Sarma, Satyam, Orenstein, Jan M., Pomerantz, Roger J., Schnell, Matthias J.
A replication-competent rhabdovirus-based vector expressing human immunodeficiency virus type 1 (HIV-1) Gag protein was characterized on human cell lines and analyzed for the induction of a cellular...
Foley, Heather D., Otero, Miguel, Orenstein, Jan M., Pomerantz, Roger J., Schnell, Matthias J.
We describe replication-competent, vaccine strain-based rabies viruses (RVs) that lack their own single glycoprotein and express, instead, a chimeric RV-human immunodeficiency virus type 1 (HIV-1)...
Faber, Milosz, Pulmanausahakul, Rojjanaporn, Hodawadekar, Suchita S., Spitsin, Sergei, McGettigan, James P., Schnell, Matthias J., ...
A recombinant rabies virus (RV) carrying two identical glycoprotein (G) genes (SPBNGA-GA) was constructed and used to determine the effect of RV G overexpression on cell viability and immunity....
McGettigan, James P., Pomerantz, Roger J., Siler, Catherine A., McKenna, Philip M., Foley, Heather D., Dietzschold, B., ...
Rabies virus (RV) vaccine strain-based vectors show great promise as vaccines against other viral diseases such as human immunodeficiency virus type 1 (HIV-1) infection and hepatitis C, but a low...
McGettigan, James P., Naper, Kristin, Orenstein, Jan, Koser, Martin, McKenna, Philip M., Schnell, Matthias J.
Recombinant rabies virus (RV) vaccine strain-based vectors have been successfully developed as vaccines against other viral diseases (J. P. McGettigan et al., J. Virol. 75:4430-4434, 2001; McGettigan...
McKenna, Philip M., Pomerantz, Roger J., Dietzschold, Bernhard, McGettigan, James P., Schnell, Matthias J.
Rabies virus (RV) vaccine strain-based vectors show significant promise as potential live-attenuated vaccines against human immunodeficiency virus type 1 (HIV-1). Here we describe a new RV construct...
Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A
Irie, Takashi, Licata, Jillian M., McGettigan, James P., Schnell, Matthias J., Harty, Ronald N.
Viral matrix proteins of several enveloped RNA viruses play important roles in virus assembly and budding and are by themselves able to bud from the cell surface in the form of lipid-enveloped,...
Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TSG101 and VPS4A
Irie, Takashi, Licata, Jillian M., McGettigan, James P., Schnell, Matthias J., Harty, Ronald N.
Rabies virus nucleoprotein as a carrier for foreign antigens
Koser, Martin L., McGettigan, James P., Tan, Gene S., Smith, Mary Ellen, Koprowski, Hilary, Dietzschold, Bernhard, ...
Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA of RV to form the viral ribonucleoprotein (RNP) complex. Antigens, such as N, presented in a highly organized...
Identification of viral genomic elements responsible for rabies virus neuroinvasiveness
Faber, Milosz, Pulmanausahakul, Rojjanaporn, Nagao, Kazuhiko, Prosniak, Mikhail, Rice, Amy B., Koprowski, Hilary, ...
Attenuated tissue culture-adapted and natural street rabies virus (RV) strains differ greatly in their neuroinvasiveness. To identify the elements responsible for the ability of an RV to enter the...
McKenna, Philip M., Aye, Pyone Pyone, Dietzschold, Bernhard, Montefiori, David C., Martin, Louis N., Marx, Preston A., ...
Rabies virus (RV) has recently been developed as a novel vaccine candidate for human immunodeficiency virus type 1 (HIV-1). The RV glycoprotein (G) can be functionally replaced by HIV-1 envelope...
Faber, Milosz, Faber, Marie-Luise, Papaneri, Amy, Bette, Michael, Weihe, Eberhard, Dietzschold, Bernhard, ...
Several rabies virus (RV) vaccine strains containing an aspartic acid (Asp) or glutamic acid (Glu) instead of an arginine (Arg) at position 333 of the RV glycoprotein (G) are apathogenic for...
Faber, Milosz, Bette, Michael, Preuss, Mirjam A. R., Pulmanausahakul, Rojjanaporn, Rehnelt, Jennifer, Schnell, Matthias J., ...
The effect of tumor necrosis factor alpha (TNF-α) on rabies virus (RV) infection of the mouse central nervous system (CNS) was studied, using recombinant RV engineered to express either soluble...
Faber, Milosz, Lamirande, Elaine W., Roberts, Anjeanette, Rice, Amy B., Koprowski, Hilary, Dietzschold, Bernhard, ...
Foreign viral proteins expressed by rabies virus (RV) have been shown to induce potent humoral and cellular immune responses in immunized animals. In addition, highly attenuated and, therefore, very...
Wu, Xianfu, Gong, Xiaoming, Foley, Heather D., Schnell, Matthias J., Fu, Zhen F.
Rabies virus nucleoprotein (N) plays vital roles in regulation of viral RNA transcription and replication by encapsidation of the nascent genomic RNA. Rabies virus N is phosphorylated, and previous...
Immunogenicity of Cytopathic and Noncytopathic Viral Vectors
Plesa, Gabriela, McKenna, Philip M., Schnell, Matthias J., Eisenlohr, Laurence C.
The impact of cytolytic versus noncytolytic viral infections on host responses is not well understood, due to limitations of the systems that have been used to address this issue. Using paired...
Recombinant rabies virus as potential live-viral vaccines for HIV-1
Schnell, Matthias J., Foley, Heather D., Siler, Catherine A., McGettigan, James P., Dietzschold, Bernhard, Pomerantz, Roger J.
Recombinant, replication-competent rabies virus (RV) vaccine strain-based vectors were developed expressing HIV type I (HIV-1) envelope glycoprotein (gp160) from both a laboratory-adapted...
Foley, Heather D., McGettigan, James P., Siler, Catherine A., Dietzschold, Bernhard, Schnell, Matthias J.
To investigate the importance of the rabies virus (RV) glycoprotein (G) in protection against rabies, we constructed a recombinant RV (rRV) in which the RV G ecto- and transmembrane domains were...
Kim, Sung-Kwon, Reed, Douglas S., Olson, Sara, Schnell, Matthias J., Rose, John K., Morton, Phillip A., ...
We compared peripheral and mucosal primary CD8 T cell responses to inflammatory and noninflammatory forms of antigen in a T cell-adoptive transfer system. Immunization with the soluble antigen,...
McGettigan, James P., Foley, Heather D., Belyakov, Igor M., Berzofsky, Jay A., Pomerantz, Roger J., Schnell, Matthias J.
Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for human immunodeficiency virus type 1 (HIV-1) infection. Our previous...
Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction
Harty, Ronald N., Brown, Melissa E., McGettigan, James P., Wang, Guangli, Jayakar, Himangi R., Huibregtse, Jon M., ...
The matrix (M) proteins of vesicular stomatitis virus (VSV) and rabies virus (RV) play a key role in both assembly and budding of progeny virions. A PPPY motif (PY motif or late-budding domain) is...
Pulmanausahakul, Rojjanaporn, Faber, Milosz, Morimoto, Kinjiro, Spitsin, Sergei, Weihe, Eberhard, Hooper, D. Craig, ...
The pathogenicity of individual rabies virus strains appears to correlate inversely with the extent of apoptotic cell death they induce and with the expression of rabies virus glycoprotein, a major...
McGettigan, James P., Sarma, Satyam, Orenstein, Jan M., Pomerantz, Roger J., Schnell, Matthias J.
A replication-competent rhabdovirus-based vector expressing human immunodeficiency virus type 1 (HIV-1) Gag protein was characterized on human cell lines and analyzed for the induction of a cellular...
Foley, Heather D., Otero, Miguel, Orenstein, Jan M., Pomerantz, Roger J., Schnell, Matthias J.
We describe replication-competent, vaccine strain-based rabies viruses (RVs) that lack their own single glycoprotein and express, instead, a chimeric RV-human immunodeficiency virus type 1 (HIV-1)...
Faber, Milosz, Pulmanausahakul, Rojjanaporn, Hodawadekar, Suchita S., Spitsin, Sergei, McGettigan, James P., Schnell, Matthias J., ...
A recombinant rabies virus (RV) carrying two identical glycoprotein (G) genes (SPBNGA-GA) was constructed and used to determine the effect of RV G overexpression on cell viability and immunity....
McGettigan, James P., Pomerantz, Roger J., Siler, Catherine A., McKenna, Philip M., Foley, Heather D., Dietzschold, B., ...
Rabies virus (RV) vaccine strain-based vectors show great promise as vaccines against other viral diseases such as human immunodeficiency virus type 1 (HIV-1) infection and hepatitis C, but a low...
Wu, Xianfu, Gong, Xiaoming, Foley, Heather D., Schnell, Matthias J., Fu, Zhen F.
Rabies virus nucleoprotein (N) plays vital roles in regulation of viral RNA transcription and replication by encapsidation of the nascent genomic RNA. Rabies virus N is phosphorylated, and previous...
McGettigan, James P., Naper, Kristin, Orenstein, Jan, Koser, Martin, McKenna, Philip M., Schnell, Matthias J.
Recombinant rabies virus (RV) vaccine strain-based vectors have been successfully developed as vaccines against other viral diseases (J. P. McGettigan et al., J. Virol. 75:4430-4434, 2001; McGettigan...
McKenna, Philip M., Pomerantz, Roger J., Dietzschold, Bernhard, McGettigan, James P., Schnell, Matthias J.
Rabies virus (RV) vaccine strain-based vectors show significant promise as potential live-attenuated vaccines against human immunodeficiency virus type 1 (HIV-1). Here we describe a new RV construct...
Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A
Irie, Takashi, Licata, Jillian M., McGettigan, James P., Schnell, Matthias J., Harty, Ronald N.
Viral matrix proteins of several enveloped RNA viruses play important roles in virus assembly and budding and are by themselves able to bud from the cell surface in the form of lipid-enveloped,...
Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TSG101 and VPS4A
Irie, Takashi, Licata, Jillian M., McGettigan, James P., Schnell, Matthias J., Harty, Ronald N.
Rabies virus nucleoprotein as a carrier for foreign antigens
Koser, Martin L., McGettigan, James P., Tan, Gene S., Smith, Mary Ellen, Koprowski, Hilary, Dietzschold, Bernhard, ...
Rabies virus (RV) nucleoprotein (N) tightly encapsidates the genomic and antigenomic RNA of RV to form the viral ribonucleoprotein (RNP) complex. Antigens, such as N, presented in a highly organized...
Identification of viral genomic elements responsible for rabies virus neuroinvasiveness
Faber, Milosz, Pulmanausahakul, Rojjanaporn, Nagao, Kazuhiko, Prosniak, Mikhail, Rice, Amy B., Koprowski, Hilary, ...
Attenuated tissue culture-adapted and natural street rabies virus (RV) strains differ greatly in their neuroinvasiveness. To identify the elements responsible for the ability of an RV to enter the...
McKenna, Philip M., Aye, Pyone Pyone, Dietzschold, Bernhard, Montefiori, David C., Martin, Louis N., Marx, Preston A., ...
Rabies virus (RV) has recently been developed as a novel vaccine candidate for human immunodeficiency virus type 1 (HIV-1). The RV glycoprotein (G) can be functionally replaced by HIV-1 envelope...
Faber, Milosz, Faber, Marie-Luise, Papaneri, Amy, Bette, Michael, Weihe, Eberhard, Dietzschold, Bernhard, ...
Several rabies virus (RV) vaccine strains containing an aspartic acid (Asp) or glutamic acid (Glu) instead of an arginine (Arg) at position 333 of the RV glycoprotein (G) are apathogenic for...
Faber, Milosz, Bette, Michael, Preuss, Mirjam A. R., Pulmanausahakul, Rojjanaporn, Rehnelt, Jennifer, Schnell, Matthias J., ...
The effect of tumor necrosis factor alpha (TNF-α) on rabies virus (RV) infection of the mouse central nervous system (CNS) was studied, using recombinant RV engineered to express either soluble...
Immunogenicity of Cytopathic and Noncytopathic Viral Vectors
Plesa, Gabriela, McKenna, Philip M., Schnell, Matthias J., Eisenlohr, Laurence C.
The impact of cytolytic versus noncytolytic viral infections on host responses is not well understood, due to limitations of the systems that have been used to address this issue. Using paired...
Tan, Gene S., Preuss, Mirjam A. R., Williams, John C., Schnell, Matthias J.
Recent studies indicate that the interaction between rabies virus (RV) phosphoprotein and the dynein light chain 8 (LC8) is essential for RV pathogenesis. Through its association with the dynein...
Dominance of a Nonpathogenic Glycoprotein Gene over a Pathogenic Glycoprotein Gene in Rabies Virus▿
Faber, Milosz, Faber, Marie-Luise, Li, Jianwei, Preuss, Mirjam A. R., Schnell, Matthias J., Dietzschold, Bernhard
The nonpathogenic phenotype of the live rabies virus (RV) vaccine SPBNGAN is determined by an Arg→Glu exchange at position 333 in the glycoprotein, designated GAN. We recently showed that after...
Pulmanausahakul, Rojjanaporn, Li, Jianwei, Schnell, Matthias J., Dietzschold, Bernhard
While the glycoprotein (G) of rabies virus (RV) is known to play a predominant role in the pathogenesis of rabies, the function of the RV matrix protein (M) in RV pathogenicity is not completely...