Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks (2003)
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...
Characterization of Panolis flammea nuclear polyhedrosis virus. (1991)
Thesis (Ph. D.)--Oxford Polytechnic, 1991.
A genetic screen identifies a cellular regulator of adeno-associated virus
Cathomen, Toni, Stracker, Travis H., Gilbert, Luz Beatriz, Weitzman, Matthew D.
Adeno-associated virus type 2 (AAV2) is a human parvovirus that has attracted attention as a vector for gene transfer. Replication and site-specific integration of the wild-type virus requires...
Cathomen, Toni, Collete, Delphine, Weitzman, Matthew D.
The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are involved in DNA replication, regulation of gene expression, and targeting site-specific integration. They bind to a specific...
Grifman, Mirta, Chen, Nancie N., Gao, Guang-ping, Cathomen, Toni, Wilson, James M., Weitzman, Matthew D.
The 34-kDa product of adenovirus E4 region open reading frame 6 (E4orf6) dramatically enhances transduction by recombinant adeno-associated virus vectors (rAAV). This is achieved by promoting the...
Cathomen, Toni, Weitzman, Matthew D.
In adenovirus-infected cells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptional activity and causes rapid turnover of the protein. To investigate the...
Yasukawa, Hideo, Yajima, Toshitaka, Duplain, Hervé, Iwatate, Mitsuo, Kido, Masakuni, Hoshijima, Masahiko, ...
Enteroviral infections of the heart are among the most commonly identified causes of acute myocarditis in children and adults and have been implicated in dilated cardiomyopathy. Although there is...
Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...
The Mre11 complex is required for ATM activation and the G2/M checkpoint
Carson, Christian T., Schwartz, Rachel A., Stracker, Travis H., Lilley, Caroline E., Lee, Darwin V., Weitzman, Matthew D.
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related PI3-like protein kinases, ataxia-telangiectasia mutated (ATM) and...
Stracker, Travis H., Cassell, Geoffrey D., Ward, Peter, Loo, Yueh-Ming, Van Breukelen, Bas, ...
Adeno-associated virus (AAV) type 2 is a human parvovirus whose replication is dependent upon cellular proteins as well as functions supplied by helper viruses. The minimal herpes simplex virus type...
Structural and functional analysis of Mre11-3
Arthur, L. Matthew, Gustausson, Karin, Hopfner, Karl-Peter, Carson, Christian T., Stracker, Travis H., Karcher, Annette, ...
The Mre11, Rad50 and Nbs1 proteins make up the conserved multi-functional Mre11 (MRN) complex involved in multiple, critical DNA metabolic processes including double-strand break repair and telomere...
Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins
Stracker, Travis H., Lee, Darwin V., Carson, Christian T., Araujo, Felipe D., Ornelles, David A., Weitzman, Matthew D.
The early transcriptional region 4 (E4) of adenovirus type 5 (Ad5) encodes gene products that modulate splicing, apoptosis, transcription, DNA replication, and repair pathways. Viruses lacking both...
Adenovirus Type 5 E4orf3 Protein Targets the Mre11 Complex to Cytoplasmic Aggresomes
Araujo, Felipe D., Stracker, Travis H., Carson, Christian T., Lee, Darwin V., Weitzman, Matthew D.
Virus infections have dramatic effects on structural and morphological characteristics of the host cell. The gene product of open reading frame 3 in the early region 4 (E4orf3) of adenovirus serotype...
A genetic screen identifies a cellular regulator of adeno-associated virus
Cathomen, Toni, Stracker, Travis H., Gilbert, Luz Beatriz, Weitzman, Matthew D.
Adeno-associated virus type 2 (AAV2) is a human parvovirus that has attracted attention as a vector for gene transfer. Replication and site-specific integration of the wild-type virus requires...
Cathomen, Toni, Collete, Delphine, Weitzman, Matthew D.
The Rep78 and Rep68 proteins of adeno-associated virus (AAV) type 2 are involved in DNA replication, regulation of gene expression, and targeting site-specific integration. They bind to a specific...
Grifman, Mirta, Chen, Nancie N., Gao, Guang-ping, Cathomen, Toni, Wilson, James M., Weitzman, Matthew D.
The 34-kDa product of adenovirus E4 region open reading frame 6 (E4orf6) dramatically enhances transduction by recombinant adeno-associated virus vectors (rAAV). This is achieved by promoting the...
Cathomen, Toni, Weitzman, Matthew D.
In adenovirus-infected cells, binding of E1B-55kDa and E4orf6 to the tumor suppressor protein p53 inhibits its transcriptional activity and causes rapid turnover of the protein. To investigate the...
Yasukawa, Hideo, Yajima, Toshitaka, Duplain, Hervé, Iwatate, Mitsuo, Kido, Masakuni, Hoshijima, Masahiko, ...
Enteroviral infections of the heart are among the most commonly identified causes of acute myocarditis in children and adults and have been implicated in dilated cardiomyopathy. Although there is...
Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks
Porteus, Matthew H., Cathomen, Toni, Weitzman, Matthew D., Baltimore, David
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA. Presently, the rate of gene targeting is too low for it to be broadly...
The Mre11 complex is required for ATM activation and the G2/M checkpoint
Carson, Christian T., Schwartz, Rachel A., Stracker, Travis H., Lilley, Caroline E., Lee, Darwin V., Weitzman, Matthew D.
The maintenance of genome integrity requires a rapid and specific response to many types of DNA damage. The conserved and related PI3-like protein kinases, ataxia-telangiectasia mutated (ATM) and...
Stracker, Travis H., Cassell, Geoffrey D., Ward, Peter, Loo, Yueh-Ming, Van Breukelen, Bas, ...
Adeno-associated virus (AAV) type 2 is a human parvovirus whose replication is dependent upon cellular proteins as well as functions supplied by helper viruses. The minimal herpes simplex virus type...
Structural and functional analysis of Mre11-3
Arthur, L. Matthew, Gustausson, Karin, Hopfner, Karl-Peter, Carson, Christian T., Stracker, Travis H., Karcher, Annette, ...
The Mre11, Rad50 and Nbs1 proteins make up the conserved multi-functional Mre11 (MRN) complex involved in multiple, critical DNA metabolic processes including double-strand break repair and telomere...
DNA repair proteins affect the lifecycle of herpes simplex virus 1
Lilley, Caroline E., Carson, Christian T., Muotri, Alysson R., Gage, Fred H., Weitzman, Matthew D.
We report that herpes simplex virus 1 (HSV-1) infection can activate and exploit a cellular DNA damage response that aids viral replication in nonneuronal cells. Early in HSV-1 infection, several...
Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins
Stracker, Travis H., Lee, Darwin V., Carson, Christian T., Araujo, Felipe D., Ornelles, David A., Weitzman, Matthew D.
The early transcriptional region 4 (E4) of adenovirus type 5 (Ad5) encodes gene products that modulate splicing, apoptosis, transcription, DNA replication, and repair pathways. Viruses lacking both...
Adenovirus Type 5 E4orf3 Protein Targets the Mre11 Complex to Cytoplasmic Aggresomes
Araujo, Felipe D., Stracker, Travis H., Carson, Christian T., Lee, Darwin V., Weitzman, Matthew D.
Virus infections have dramatic effects on structural and morphological characteristics of the host cell. The gene product of open reading frame 3 in the early region 4 (E4orf3) of adenovirus serotype...
Dheekollu, Jayaraju, Deng, Zhong, Wiedmer, Andreas, Weitzman, Matthew D., Lieberman, Paul M.
Recombination-like structures formed at origins of DNA replication may contribute to replication fidelity, sister chromatid cohesion, chromosome segregation, and overall genome stability. The...
The Mre11/Rad50/Nbs1 Complex Limits Adeno-Associated Virus Transduction and Replication▿
Schwartz, Rachel A., Palacios, Jose Alejandro, Cassell, Geoffrey D., Adam, Sarah, Giacca, Mauro, Weitzman, Matthew D.
Adeno-associated virus (AAV) is a parvovirus with a small single-stranded DNA genome that relies on cellular replication machinery together with functions supplied by coinfecting helper viruses. The...