An, Dong Sung, Donahue, Robert E., Kamata, Masakazu, Poon, Betty, Metzger, Mark, Mao, Si-Hua, ...
RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions,...
Nishizawa, Masako, Kamata, Masakazu, Katsumata, Ryoichi, Aida, Yoko
Viral protein R (Vpr) of human immunodeficiency virus type 1 inhibits cell proliferation by arresting the cell cycle at the G2 phase and inducing to apoptosis after G2 arrest. We have reported...
To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions...
Yuan, Huidong, Kamata, Masakazu, Xie, Yi-Ming, Chen, Irvin S. Y.
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G2/M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G2...
Kamata, Masakazu, Nitahara-Kasahara, Yuko, Miyamoto, Yoichi, Yoneda, Yoshihiro, Aida, Yoko
Viral protein R (Vpr) of human immunodeficiency virus type 1 has potent karyophilic properties, but details of the mechanism by which it enters the nucleus remain to be clarified. We reported...
Nishizawa, Masako, Kamata, Masakazu, Katsumata, Ryoichi, Aida, Yoko
Viral protein R (Vpr) of human immunodeficiency virus type 1 inhibits cell proliferation by arresting the cell cycle at the G2 phase and inducing to apoptosis after G2 arrest. We have reported...
To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa cells with a panel of expression vectors that encode mutant Vpr protein with deletions or substitutions...
Yuan, Huidong, Kamata, Masakazu, Xie, Yi-Ming, Chen, Irvin S. Y.
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G2/M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G2...
Kamata, Masakazu, Nitahara-Kasahara, Yuko, Miyamoto, Yoichi, Yoneda, Yoshihiro, Aida, Yoko
Viral protein R (Vpr) of human immunodeficiency virus type 1 has potent karyophilic properties, but details of the mechanism by which it enters the nucleus remain to be clarified. We reported...
Nitahara-Kasahara, Yuko, Kamata, Masakazu, Yamamoto, Takuya, Zhang, Xianfeng, Miyamoto, Yoichi, Muneta, Koho, ...
Monocytes/macrophages are major targets of human immunodeficiency virus type 1 (HIV-1) infection. The viral preintegration complex (PIC) of HIV-1 enters the nuclei of monocyte-derived macrophages,...
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates
An, Dong Sung, Donahue, Robert E., Kamata, Masakazu, Poon, Betty, Metzger, Mark, Mao, Si-Hua, ...
RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions,...
Kamata, Masakazu, Watanabe, Nobumoto, Nagaoka, Yoshiko, Chen, Irvin S. Y.
Human immunodeficiency virus type 1 Vpr is a virion-associated accessory protein that has multiple activities within an infected cell. One of the most dramatic effects of Vpr is the induction of cell...