Mary Elizabeth Patti

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Patti, Mary Elizabeth, Butte, Atul J., Crunkhorn, Sarah, Cusi, Kenneth, Berria, Rachele, Kashyap, Sangeeta, ...

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal...

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

Cusi, Kenneth, Maezono, Katsumi, Osman, Abdullah, Pendergrass, Merri, Patti, Mary Elizabeth, Pratipanawatr, Thongchai, ...

The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with type 2 diabetes suggests a defect in the proximal part of the insulin signaling network. We sought to...

Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes

Tiffin, Nicki, Adie, Euan, Turner, Frances, Brunner, Han G., Van Driel, Marc A., Oti, Martin, ...

Genome-wide experimental methods to identify disease genes, such as linkage analysis and association studies, generate increasingly large candidate gene sets for which comprehensive empirical...

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

Patti, Mary Elizabeth, Butte, Atul J., Crunkhorn, Sarah, Cusi, Kenneth, Berria, Rachele, Kashyap, Sangeeta, ...

Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal...

Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle

Cusi, Kenneth, Maezono, Katsumi, Osman, Abdullah, Pendergrass, Merri, Patti, Mary Elizabeth, Pratipanawatr, Thongchai, ...

The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with type 2 diabetes suggests a defect in the proximal part of the insulin signaling network. We sought to...

Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes

Tiffin, Nicki, Adie, Euan, Turner, Frances, Brunner, Han G., Van Driel, Marc A., Oti, Martin, ...

Genome-wide experimental methods to identify disease genes, such as linkage analysis and association studies, generate increasingly large candidate gene sets for which comprehensive empirical...