Eric Spierings, Matthijs Hendriks, Léna Absi, Angelica Canossi, Sonal Chhaya, John Crowley, ...
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen–matched solid organ and stem cell...
Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, ...
BackgroundVery little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of...
Identification of the ancestral killer immunoglobulin-like receptor gene in primates (2006)
Sambrook, Jennifer G, Bashirova, Arman, Andersen, Hanne, Piatak, Mike, Vernikos, George S, Coggill, Penny, ...
Abstract Background Killer Immunoglobulin-like Receptors (KIR) are essential immuno-surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte...
KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections (2006)
Ying Qi, Maureen P. Martin, Xiaojiang Gao, Lisa Jacobson, James J. Goedert, Susan Buchbinder, ...
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...
James A. Traherne, Roger Horton, Anne N. Roberts, Marcos M. Miretti, Matthew E. Hurles, C. Andrew Stewart, ...
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection (2004)
Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, ...
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of...
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection (2004)
Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, ...
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of...
Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...
There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...
Dating the Origin of the CCR5-Delta32 AIDS-Resistance Allele by the Coalescence of Haplotypes (2001)
Stephen J. O'brien, J. Claiborne Stephens, David E. Reich, David B. Goldstein, Hyoung Doo Shin, Michael W. Smith, ...
rick, National Cancer Institute, Frederick, MD; 3 Molecular Genetics Department, Hospital Duran i Reynals (IRO), Barcelona; 4 Institut fur Humangenetik, Medizinische Hochschule, Hannover; 5 First...
Michael S. Ross, Mary Carrington, Laura J. Flynn, Pablo L. Ruiz
A tree species replacement sequence for dry broadleaved forests (tropical hardwood hammocks) in the upper Florida Keys was inferred from species abundances in stands abandoned from agriculture or...
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El Omar, Emad M., Carrington, Mary, Chow, Wong-Ho, McColl, Kenneth E. L., Bream, Jay H., Young, Howard A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Esser, Mark T., Bess, Julian W., Suryanarayana, Kalachar, Chertova, Elena, Marti, Darlene, Carrington, Mary, ...
Increased levels of apoptosis are seen in human immunodeficiency virus (HIV) infection, and this has been proposed as an important mechanism contributing to HIV pathogenesis. However, interpretation...
Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
Wu, Li, Bashirova, Arman A., Martin, Thomas D., Villamide, Loreley, Mehlhop, Erin, Chertov, Andrei O., ...
Here, we describe the isolation and characterization of the rhesus macaque homolog for human DC-SIGN, a dendritic cell-specific C-type lectin. mac-DC-SIGN is 92% identical to hu-DC-SIGN. mac-DC-SIGN...
HLA-Cw*04 and Hepatitis C Virus Persistence
Thio, Chloe L., Gao, Xiaojiang, Goedert, James J., Vlahov, David, Nelson, Kenrad E., Hilgartner, Margaret W., ...
In studies of acute hepatitis C virus (HCV) infection, the early host immune response is one of the determinants of viral persistence. The class I human leukocyte antigens (HLA), which present...
Jin, Xia, Gao, Xiaojiang, Deschenes, Geoffrey R., Nelson, George W., O'Brien, Stephen J., ...
Human immunodeficiency virus type 1 (HIV-1)-infected individuals with HLA-B*35 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3501 (B*35-PY). The...
Novel Member of the CD209 (DC-SIGN) Gene Family in Primates
Bashirova, Arman A., Wu, Li, Cheng, Jie, Martin, Thomas D., Martin, Maureen P., Benveniste, Raoul E., ...
Two CD209 family genes identified in humans, CD209 (DC-SIGN) and CD209L (DC-SIGNR/L-SIGN), encode C-type lectins that serve as adhesion receptors for ICAM-2 and ICAM-3 and participate in the...
Comprehensive Analysis of Class I and Class II HLA Antigens and Chronic Hepatitis B Virus Infection
Thio, Chloe L., Thomas, David L., Karacki, Peter, Gao, Xiaojiang, Marti, Darlene, Kaslow, Richard A., ...
Following an acute hepatitis B virus (HBV) infection, clearance or persistence is determined in part by the vigor and breadth of the host immune response. Since the human leukocyte antigen system...
Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...
There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...
Sambrook, Jennifer G., Bashirova, Arman, Palmer, Sophie, Sims, Sarah, Trowsdale, John, Abi-Rached, Laurent, ...
The human killer immunoglobulin-like receptors (KIR) are encoded within the Leukocyte Receptor Complex (LRC) on chromosome 19q13.4. Here we report the comparative genomic analysis of single KIR...
Traherne, James A, Horton, Roger, Roberts, Anne N, Miretti, Marcos M, Hurles, Matthew E, Stewart, C. Andrew, ...
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...
Identification of the ancestral killer immunoglobulin-like receptor gene in primates
Sambrook, Jennifer G, Bashirova, Arman, Andersen, Hanne, Piatak, Mike, Vernikos, George S, Coggill, Penny, ...
Yant, Levi J., Friedrich, Thomas C., Johnson, Randall C., May, Gemma E., Maness, Nicholas J., Enz, Alissa M., ...
Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the...
KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
Qi, Ying, Martin, Maureen P, Gao, Xiaojiang, Jacobson, Lisa, Goedert, James J, Buchbinder, Susan, ...
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...
Yant, Levi J., Friedrich, Thomas C., Johnson, Randall C., May, Gemma E., Maness, Nicholas J., Enz, Alissa M., ...
Bashirova, Arman A., Bleiber, Gabriela, Qi, Ying, Hutcheson, Holli, Yamashita, Traci, Johnson, Randall C., ...
Tumor susceptibility gene 101 (TSG101) encodes a host cellular protein that is appropriated by human immunodeficiency virus type 1 (HIV-1) in the budding process of viral particles from infected...
Altfeld, Marcus, Kalife, Elizabeth T, Qi, Ying, Streeck, Hendrik, Lichterfeld, Mathias, Johnston, Mary N, ...
A subset of CD8+ T cell epitopes within HIV-1 are consistently targeted early after infection. This could explain some of the protective effect of certain HLA class I alleles on HIV-1 disease...
Esser, Mark T., Bess, Julian W., Suryanarayana, Kalachar, Chertova, Elena, Marti, Darlene, Carrington, Mary, ...
Increased levels of apoptosis are seen in human immunodeficiency virus (HIV) infection, and this has been proposed as an important mechanism contributing to HIV pathogenesis. However, interpretation...
Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
Wu, Li, Bashirova, Arman A., Martin, Thomas D., Villamide, Loreley, Mehlhop, Erin, Chertov, Andrei O., ...
Here, we describe the isolation and characterization of the rhesus macaque homolog for human DC-SIGN, a dendritic cell-specific C-type lectin. mac-DC-SIGN is 92% identical to hu-DC-SIGN. mac-DC-SIGN...
HLA-Cw*04 and Hepatitis C Virus Persistence
Thio, Chloe L., Gao, Xiaojiang, Goedert, James J., Vlahov, David, Nelson, Kenrad E., Hilgartner, Margaret W., ...
In studies of acute hepatitis C virus (HCV) infection, the early host immune response is one of the determinants of viral persistence. The class I human leukocyte antigens (HLA), which present...
Jin, Xia, Gao, Xiaojiang, Deschenes, Geoffrey R., Nelson, George W., O'Brien, Stephen J., ...
Human immunodeficiency virus type 1 (HIV-1)-infected individuals with HLA-B*35 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3501 (B*35-PY). The...
Novel Member of the CD209 (DC-SIGN) Gene Family in Primates
Bashirova, Arman A., Wu, Li, Cheng, Jie, Martin, Thomas D., Martin, Maureen P., Benveniste, Raoul E., ...
Two CD209 family genes identified in humans, CD209 (DC-SIGN) and CD209L (DC-SIGNR/L-SIGN), encode C-type lectins that serve as adhesion receptors for ICAM-2 and ICAM-3 and participate in the...
Comprehensive Analysis of Class I and Class II HLA Antigens and Chronic Hepatitis B Virus Infection
Thio, Chloe L., Thomas, David L., Karacki, Peter, Gao, Xiaojiang, Marti, Darlene, Kaslow, Richard A., ...
Following an acute hepatitis B virus (HBV) infection, clearance or persistence is determined in part by the vigor and breadth of the host immune response. Since the human leukocyte antigen system...
High-Resolution Patterns of Meiotic Recombination across the Human Major Histocompatibility Complex
Cullen, Michael, Perfetto, Stephen P., Klitz, William, Nelson, George, Carrington, Mary
Definitive characteristics of meiotic recombination events over large (i.e., >1 Mb) segments of the human genome remain obscure, yet they are essential for establishing the haplotypic structure of...
Martin, Maureen P., Lederman, Michael M., Hutcheson, Holli B., Goedert, James J., Nelson, George W., Van Kooyk, Yvette, ...
There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating...
Sambrook, Jennifer G., Bashirova, Arman, Palmer, Sophie, Sims, Sarah, Trowsdale, John, Abi-Rached, Laurent, ...
The human killer immunoglobulin-like receptors (KIR) are encoded within the Leukocyte Receptor Complex (LRC) on chromosome 19q13.4. Here we report the comparative genomic analysis of single KIR...
An Integrated Haplotype Map of the Human Major Histocompatibility Complex
Walsh, Emily C., Mather, Kristie A., Schaffner, Stephen F., Farwell, Lisa, Daly, Mark J., Patterson, Nick, ...
Numerous studies have clearly indicated a role for the major histocompatibility complex (MHC) in susceptibility to autoimmune diseases. Such studies have focused on the genetic variation of a small...
Traherne, James A, Horton, Roger, Roberts, Anne N, Miretti, Marcos M, Hurles, Matthew E, Stewart, C. Andrew, ...
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer...
Yant, Levi J., Friedrich, Thomas C., Johnson, Randall C., May, Gemma E., Maness, Nicholas J., Enz, Alissa M., ...
Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the...
Yant, Levi J., Friedrich, Thomas C., Johnson, Randall C., May, Gemma E., Maness, Nicholas J., Enz, Alissa M., ...
Bashirova, Arman A., Bleiber, Gabriela, Qi, Ying, Hutcheson, Holli, Yamashita, Traci, Johnson, Randall C., ...
Tumor susceptibility gene 101 (TSG101) encodes a host cellular protein that is appropriated by human immunodeficiency virus type 1 (HIV-1) in the budding process of viral particles from infected...
KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections
Qi, Ying, Martin, Maureen P, Gao, Xiaojiang, Jacobson, Lisa, Goedert, James J, Buchbinder, Susan, ...
The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual...
Identification of the ancestral killer immunoglobulin-like receptor gene in primates
Sambrook, Jennifer G, Bashirova, Arman, Andersen, Hanne, Piatak, Mike, Vernikos, George S, Coggill, Penny, ...
Altfeld, Marcus, Kalife, Elizabeth T, Qi, Ying, Streeck, Hendrik, Lichterfeld, Mathias, Johnston, Mary N, ...
A subset of CD8+ T cell epitopes within HIV-1 are consistently targeted early after infection. This could explain some of the protective effect of certain HLA class I alleles on HIV-1 disease...
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El Omar, Emad M., Carrington, Mary, Chow, Wong-Ho, McColl, Kenneth E. L., Bream, Jay H., Young, Howard A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Thio, Chloe L., Astemborski, Jacquie, Bashirova, Arman, Mosbruger, Timothy, Greer, Spencer, Witt, Mallory D., ...
Recovery from acute hepatitis B virus (HBV) infection requires a broad, vigorous T-cell response, which is enhanced in mice when chemokine receptor 5 (CCR5) is missing. To test the hypothesis that...
Spierings, Eric, Hendriks, Matthijs, Absi, Léna, Canossi, Angelica, Chhaya, Sonal, Crowley, John, ...
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen–matched solid organ and stem cell...
Bozzacco, Leonia, Trumpfheller, Christine, Siegal, Frederick P., Mehandru, Saurabh, Markowitz, Martin, Carrington, Mary, ...
Optimal HIV vaccines should elicit CD8+ T cells specific for HIV proteins presented on MHC class I products, because these T cells contribute to host resistance to viruses. We had previously found...
Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication▿
Loffredo, John T., Maxwell, Jess, Qi, Ying, Glidden, Chrystal E., Borchardt, Gretta J., Soma, Taeko, ...
Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed...
Mehandru, Saurabh, Vcelar, Brigitta, Wrin, Terri, Stiegler, Gabriela, Joos, Beda, Mohri, Hiroshi, ...
Three neutralizing monoclonal antibodies (MAbs), 2G12, 2F5, and 4E10, with activity in vitro and in vivo were administered in an open-label, nonrandomized, proof-of-concept study to attempt to...
Ahlenstiel, Golo, Martin, Maureen P., Gao, Xiaojiang, Carrington, Mary, Rehermann, Barbara
Genetic studies suggest a role for killer cell immunoglobulin-like receptor/HLA (KIR/HLA) compound genotypes in the outcome of viral infections, but functional data to explain these epidemiological...
Hiby, Susan E., Walker, James J., O'Shaughnessy, Kevin M., Redman, Christopher W.G., Carrington, Mary, Trowsdale, John, ...
Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is evidence that the condition has an...
Carrington, Mary, Wang, Sophia, Martin, Maureen P., Gao, Xiaojiang, Schiffman, Mark, Cheng, Jie, ...
Killer immunoglobulin-like receptor (KIR) recognition of specific human histocompatibility leukocyte antigen (HLA) class I allotypes contributes to the array of receptor–ligand interactions that...
Statistical Resolution of Ambiguous HLA Typing Data
Listgarten, Jennifer, Brumme, Zabrina, Kadie, Carl, Xiaojiang, Gao, Walker, Bruce, Carrington, Mary, ...
High-resolution HLA typing plays a central role in many areas of immunology, such as in identifying immunogenetic risk factors for disease, in studying how the genomes of pathogens evolve in response...
DNA Methylation Maintains Allele-specific KIR Gene Expression in Human Natural Killer Cells
Chan, Huei-Wei, Kurago, Zoya B., Stewart, C. Andrew, Wilson, Michael J., Martin, Maureen P., Mace, Brian E., ...
Killer immunoglobulin-like receptors (KIR) bind self–major histocompatibility complex class I molecules, allowing natural killer (NK) cells to recognize aberrant cells that have down-regulated...
Bashirova, Arman A., Geijtenbeek, Teunis B.H., Van Vliet, Sandra J., Eilering, Jeroen B.G., Martin, Maureen P., ...
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3–grabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T...
Giraldo-Vela, Juan P., Rudersdorf, Richard, Chung, Chungwon, Qi, Ying, Wallace, Lyle T., Bimber, Benjamin, ...
The role of CD4+ T cells in the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication is not well understood. Even though strong HIV-