Martin Srayko

Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans (2007)

Lundin, Victor F., Srayko, Martin, Hyman, Anthony A., Leroux, Michel R.

The efficient folding of actin and tubulin in vitro and in Saccharomyces cerevisiae is known to require the molecular chaperones prefoldin and CCT, yet little is known about the functions of these...

Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression (2007)

Stirling, Peter C., Srayko, Martin, Takhar, Karam S., Pozniakovsky, Andrei, Hyman, Anthony A., Leroux, Michel R.

The Chaperonin Containing Tcp1 (CCT) maintains cellular protein folding homeostasis in the eukaryotic cytosol by assisting the biogenesis of many proteins, including actins, tubulins, and regulators...

The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly (2007)

Schlaitz, Anne-Lore, Srayko, Martin, Dammermann, Alexander, Quintin, Sophie, Wielsch, Natalie, MacLeod, Ian, ...

Microtubule behavior changes during the cell cycle and during spindle assembly. However, it remains unclear how these changes are regulated and coordinated. We describe a complex that targets the...

Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis (2006)

Srayko, Martin, O'Toole, Eileen T, Hyman, Anthony A, Muller-Reichert, Thomas

Katanin is a heterodimer that exhibits ATP-dependent microtubule-severing activity in vitro. In Xenopus egg extracts, katanin activity correlates with the addition of cyclin B/cdc2, suggesting a role...

Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules. (2003)

Srayko, Martin, Quintin, Sophie, Schwager, Anne, Hyman, Anthony A

TACC (transforming acidic coiled-coil) proteins were first identified by their ability to transform cell lines [1], and links between human cancer and the overexpression of TACC proteins highlight...

The Caenorhabditis elegans Microtubule-severing Complex MEI-1/MEI-2 Katanin Interacts Differently with Two Superficially Redundant β-Tubulin Isotypes

Lu, Chenggang, Srayko, Martin, Mains, Paul E.

The microtubule-severing protein complex katanin is required for a variety of important microtubule-base morphological changes in both animals and plants. Caenorhabditis elegans katanin is encoded by...

MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis

Srayko, Martin, Buster, Dan W., Bazirgan, Omar A., McNally, Francis J., Mains, Paul E.

The Caenorhabditis elegans meiotic spindle is morphologically distinct from the first mitotic spindle, yet both structures form in the same cytoplasm ∼20 minutes apart. The mei-1 and mei-2 genes of...

The Caenorhabditis elegans Microtubule-severing Complex MEI-1/MEI-2 Katanin Interacts Differently with Two Superficially Redundant β-Tubulin Isotypes

Lu, Chenggang, Srayko, Martin, Mains, Paul E.

The microtubule-severing protein complex katanin is required for a variety of important microtubule-base morphological changes in both animals and plants. Caenorhabditis elegans katanin is encoded by...

MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis

Srayko, Martin, Buster, Dan W., Bazirgan, Omar A., McNally, Francis J., Mains, Paul E.

The Caenorhabditis elegans meiotic spindle is morphologically distinct from the first mitotic spindle, yet both structures form in the same cytoplasm ∼20 minutes apart. The mei-1 and mei-2 genes of...

Functional Interaction between Phosducin-like Protein 2 and Cytosolic Chaperonin Is Essential for Cytoskeletal Protein Function and Cell Cycle Progression

Stirling, Peter C., Srayko, Martin, Takhar, Karam S., Pozniakovsky, Andrei, Hyman, Anthony A., Leroux, Michel R.

The C haperonin Containing Tcp1 (CCT) maintains cellular protein folding homeostasis in the eukaryotic cytosol by assisting the biogenesis of many proteins, including actins, tubulins, and regulators...