Prediction of effective genome size in metagenomic samples (2007)
Raes, Jeroen, Korbel, Jan O, Lercher, Martin J, Von Mering, Christian, Bork, Peer
Abstract We introduce a novel computational approach to predict effective genome size (EGS; a measure that includes multiple plasmid copies, inserted sequences, and associated phages and viruses)...
Genome-wide acceleration of protein evolution in flies (Diptera) (2006)
Savard, Joël, Tautz, Diethard, Lercher, Martin J
Abstract Background The rate of molecular evolution varies widely between proteins, both within and among lineages. To what extent is this variation influenced by genome-wide, lineage-specific...
Hurst, Laurence D, Lercher, Martin J
Abstract Background Prior to the sequencing of the human genome it was typically assumed that, tandem duplication aside, gene order is for the most part random. Numerous observers, however,...
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes (2005)
Peter D. Keightley, Martin J. Lercher, Adam Eyre-Walker
A comparison of hominid and rodent lineages reveals that the gene control regions of hominids are not conserved and are accumulating mutations, suggesting widespread degradation of the hominid genome.
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes (2005)
Peter D. Keightley, Martin J. Lercher, Adam Eyre-Walker
Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these...
Gene Expression, Synteny, and Local Similarity in Human Noncoding Mutation Rates. (2004)
Webster, Matthew T., Smith, Nick G.C., Lercher, Martin J., Ellegren, Hans
The human genome is organized with regard to many features such as isochores, Giemsa bands, clusters of genes with similar expression patterns, and contiguous regions with shared evolutionary...
Is prokaryotic complexity limited by accelerated growth in regulatory overhead? (2003)
Croft, Larry J, Lercher, Martin J, Gagen, Michael J, Mattick, John S
Abstract Background Increased biological complexity is generally associated with the addition of new genetic information, which must be integrated into the existing regulatory network that operates...
Is prokaryotic complexity limited by accelerated growth in regulatory overhead? (2003)
Croft, Larry J., Lercher, Martin J., Gagen, Michael J., Mattick, John S.
Increased biological complexity is generally associated with the addition of new genetic information, which must be integrated into the existing regulatory network that operates within the cell....
Lercher, Martin J., Chamary, Jean-Vincent, Hurst, Laurence D.
In mammalian genomes, linked genes show similar rates of evolution, both at fourfold degenerate synonymous sites (K4) and at nonsynonymous sites (KA). Although it has been suggested that the local...
Lercher, Martin J., Blumenthal, Thomas, Hurst, Laurence D.
In many eukaryotic species, gene order is not random. In humans, flies, and yeast, there is clustering of coexpressed genes that cannot be explained as a trivial consequence of tandem duplication. In...
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
Keightley, Peter D, Lercher, Martin J, Eyre-Walker, Adam
Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these...
The evolution of isochores: evidence from SNP frequency distributions.
Lercher, Martin J, Smith, Nick G C, Eyre-Walker, Adam, Hurst, Laurence D
The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here...
X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila
Legube, Gaëlle, McWeeney, Shannon K., Lercher, Martin J., Akhtar, Asifa
In Drosophila, dosage compensation is achieved by a twofold up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. How...
Lercher, Martin J., Chamary, Jean-Vincent, Hurst, Laurence D.
In mammalian genomes, linked genes show similar rates of evolution, both at fourfold degenerate synonymous sites (K4) and at nonsynonymous sites (KA). Although it has been suggested that the local...
Lercher, Martin J., Blumenthal, Thomas, Hurst, Laurence D.
In many eukaryotic species, gene order is not random. In humans, flies, and yeast, there is clustering of coexpressed genes that cannot be explained as a trivial consequence of tandem duplication. In...
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
Keightley, Peter D, Lercher, Martin J, Eyre-Walker, Adam
Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these...
The evolution of isochores: evidence from SNP frequency distributions.
Lercher, Martin J, Smith, Nick G C, Eyre-Walker, Adam, Hurst, Laurence D
The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here...
X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila
Legube, Gaëlle, McWeeney, Shannon K., Lercher, Martin J., Akhtar, Asifa
In Drosophila, dosage compensation is achieved by a twofold up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. How...
Prediction of effective genome size in metagenomic samples
Raes, Jeroen, Korbel, Jan O, Lercher, Martin J, Von Mering, Christian, Bork, Peer
A novel computational approach shows a link between genome size and habitat from analysis of environmental metagenomic DNA reads.
Savard, Joël, Tautz, Diethard, Richards, Stephen, Weinstock, George M., Gibbs, Richard A., Werren, John H., ...
Comparative studies require knowledge of the evolutionary relationships between taxa. However, neither morphological nor paleontological data have been able to unequivocally resolve the major groups...