Marta L. Marthas

VSV/MVA vaccine rapidly elicits SIV antibodies and local and systemic SIV T cell responses in macaque neonates but does not prevent SIV dissemination after oral challenge (2008)

Abel, Kristina, Van Rompay, Koen KA, Eastlick, Juliet, Moore, Joseph, Lemieux, Mathieu, Schmidt, Kimberly, ...

No abstract available.

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection (2007)

Van Rompay, Koen KA, Johnson, Jeffrey A, Blackwood, Emily J, Singh, Raman P, Lipscomb, Jonathan, Matthews, Timothy B, ...

Abstract Background We reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the...

Non-neutralizing antibodies and vaccine-induced protection (2006)

Demberg, Thorsten, Florese, Ruth H, Gomez-Roman, V Raul, Larsen, Kay, Van Rompay, Koen KA, Marthas, Marta L, ...

No abstract available.

Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11 (2006)

Van Rompay, Koen KA, Blackwood, Emily J, Landucci, Gary, Forthal, Don, Marthas, Marta L

Abstract Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor...

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals (2005)

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Abstract Background Oral infection of infant macaques with simian immunodeficiency virus (SIV) is a useful animal model to test interventions to reduce postnatal HIV transmission via breast-feeding....

9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) Therapy Prolongs Survival of Infant Macaques Inoculated with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

Van Rompay, Koen K. A., Cherrington, Julie M., Marthas, Marta L., Lamy, Patrick D., Dailey, Peter J., Canfield, Don R., ...

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a useful animal model of human immunodeficiency virus infection for the study of the emergence and clinical implications of...

Early Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine Treatment Favorably Alters the Subsequent Disease Course in Simian Immunodeficiency Virus-Infected Newborn Rhesus Macaques

Van Rompay, Koen K. A., Dailey, Peter J., Tarara, Ross P., Canfield, Don R., Aguirre, Nancy L., Cherrington, Julie M., ...

Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study disease pathogenesis and to develop intervention strategies aimed at...

Prophylactic and Therapeutic Benefits of Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine (PMPA) Administration to Newborn Macaques following Oral Inoculation with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

Van Rompay, Koen K. A., Miller, Michael D., Marthas, Marta L., Margot, Nicolas A., Dailey, Peter J., Canfield, Don R., ...

Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing...

Route of Simian Immunodeficiency Virus Inoculation Determines the Complexity but Not the Identity of Viral Variant Populations That Infect Rhesus Macaques

Greenier, Jennifer L., Miller, Christopher J., Lu, Ding, Dailey, Peter J., Lü, Fabien X., Kunstman, Kevin J., ...

A better understanding of the host and viral factors associated with human immunodeficiency virus (HIV) transmission is essential to developing effective strategies to curb the global HIV epidemic....

Rev-Independent Simian Immunodeficiency Virus Strains Are Nonpathogenic in Neonatal Macaques

Von Gegerfelt, Agneta S., Liska, Vladimir, Li, Pei-Lin, McClure, Harold M., Horie, Kyoji, Nappi, Filomena, ...

The viral protein Rev is essential for the export of the subset of unspliced and partially spliced lentiviral mRNAs and the production of structural proteins. Rev and its RNA binding site RRE can be...

Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251

Van Rompay, Koen K. A., Greenier, Jennifer L., Cole, Kelly Stefano, Earl, Patricia, Moss, Bernard, Steckbeck, Jonathan D., ...

There is an urgent need for active immunization strategies that, if administered shortly after birth, could protect infants in developing countries from acquiring human immunodeficiency virus (HIV)...

Functional and Morphological Development of Lymphoid Tissues and Immune Regulatory and Effector Function in Rhesus Monkeys: Cytokine-Secreting Cells, Immunoglobulin-Secreting Cells, and CD5+ B-1 Cells Appear Early in Fetal Development

Makori, Norbert, Tarantal, Alice F., Lü, Fabien X., Rourke, Tracy, Marthas, Marta L., McChesney, Michael B., ...

Little is known regarding the timing of immune ontogeny and effector function in fetal humans and nonhuman primates. We studied the organization of lymphocyte and antigen-presenting cell populations...

Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239

Vogel, Thorsten U., Reynolds, Matthew R., Fuller, Deborah H., Vielhuber, Kathy, Shipley, Tim, Fuller, James T., ...

Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating...

CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment

Van Rompay, Koen K. A., Singh, Raman P., Pahar, Bapi, Sodora, Donald L., Wingfield, Casey, Lawson, Jonathan R., ...

The ability of tenofovir to suppress viremia in simian immunodeficiency virus (SIV)-infected macaques for years despite the presence of virulent viral mutants with reduced in vitro susceptibility is...

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

Van Rompay, Koen K. A., Brignolo, Laurie L., Meyer, Dennis J., Jerome, Christopher, Tarara, Ross, Spinner, Abigail, ...

The reverse transcriptase inhibitor 9-[2-(phosphonomethoxy)propyl]adenine (PMPA; tenofovir) was previously found to offer strong prophylactic and therapeutic benefits in an infant macaque model of...

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

Van Rompay, Koen K. A., Brignolo, Laurie L., Meyer, Dennis J., Jerome, Christopher, Tarara, Ross, Spinner, Abigail, ...

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11

Van Rompay, Koen KA, Blackwood, Emily J, Landucci, Gary, Forthal, Don, Marthas, Marta L

Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor replication...

Rapid Virus Dissemination in Infant Macaques after Oral Simian Immunodeficiency Virus Exposure in the Presence of Local Innate Immune Responses

Abel, Kristina, Pahar, Bapi, Van Rompay, Koen K. A., Fritts, Linda, Sin, Clarissa, Schmidt, Kimberli, ...

A vaccine to protect human immunodeficiency virus (HIV)-exposed infants is an important goal in the global fight against the HIV pandemic. Two major challenges in pediatric HIV vaccine design are the...

Structured Treatment Interruptions with Tenofovir Monotherapy for Simian Immunodeficiency Virus-Infected Newborn Macaques

Van Rompay, Koen K. A., Singh, Raman P., Heneine, Walid, Johnson, Jeffrey A., Montefiori, David C., Bischofberger, Norbert, ...

We demonstrated previously that prolonged tenofovir treatment of infant macaques, starting early during infection with virulent simian immunodeficiency virus (SIVmac251), can lead to persistently low...

9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) Therapy Prolongs Survival of Infant Macaques Inoculated with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

Van Rompay, Koen K. A., Cherrington, Julie M., Marthas, Marta L., Lamy, Patrick D., Dailey, Peter J., Canfield, Don R., ...

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a useful animal model of human immunodeficiency virus infection for the study of the emergence and clinical implications of...

Early Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine Treatment Favorably Alters the Subsequent Disease Course in Simian Immunodeficiency Virus-Infected Newborn Rhesus Macaques

Van Rompay, Koen K. A., Dailey, Peter J., Tarara, Ross P., Canfield, Don R., Aguirre, Nancy L., Cherrington, Julie M., ...

Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study disease pathogenesis and to develop intervention strategies aimed at...

Prophylactic and Therapeutic Benefits of Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine (PMPA) Administration to Newborn Macaques following Oral Inoculation with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

Van Rompay, Koen K. A., Miller, Michael D., Marthas, Marta L., Margot, Nicolas A., Dailey, Peter J., Canfield, Don R., ...

Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study pathogenesis and to develop intervention strategies aimed at preventing...

Route of Simian Immunodeficiency Virus Inoculation Determines the Complexity but Not the Identity of Viral Variant Populations That Infect Rhesus Macaques

Greenier, Jennifer L., Miller, Christopher J., Lu, Ding, Dailey, Peter J., Lü, Fabien X., Kunstman, Kevin J., ...

A better understanding of the host and viral factors associated with human immunodeficiency virus (HIV) transmission is essential to developing effective strategies to curb the global HIV epidemic....

Rev-Independent Simian Immunodeficiency Virus Strains Are Nonpathogenic in Neonatal Macaques

Von Gegerfelt, Agneta S., Liska, Vladimir, Li, Pei-Lin, McClure, Harold M., Horie, Kyoji, Nappi, Filomena, ...

The viral protein Rev is essential for the export of the subset of unspliced and partially spliced lentiviral mRNAs and the production of structural proteins. Rev and its RNA binding site RRE can be...

Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251

Van Rompay, Koen K. A., Greenier, Jennifer L., Cole, Kelly Stefano, Earl, Patricia, Moss, Bernard, Steckbeck, Jonathan D., ...

There is an urgent need for active immunization strategies that, if administered shortly after birth, could protect infants in developing countries from acquiring human immunodeficiency virus (HIV)...

Functional and Morphological Development of Lymphoid Tissues and Immune Regulatory and Effector Function in Rhesus Monkeys: Cytokine-Secreting Cells, Immunoglobulin-Secreting Cells, and CD5+ B-1 Cells Appear Early in Fetal Development

Makori, Norbert, Tarantal, Alice F., Lü, Fabien X., Rourke, Tracy, Marthas, Marta L., McChesney, Michael B., ...

Little is known regarding the timing of immune ontogeny and effector function in fetal humans and nonhuman primates. We studied the organization of lymphocyte and antigen-presenting cell populations...

Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239

Vogel, Thorsten U., Reynolds, Matthew R., Fuller, Deborah H., Vielhuber, Kathy, Shipley, Tim, Fuller, James T., ...

Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating...

CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment

Van Rompay, Koen K. A., Singh, Raman P., Pahar, Bapi, Sodora, Donald L., Wingfield, Casey, Lawson, Jonathan R., ...

The ability of tenofovir to suppress viremia in simian immunodeficiency virus (SIV)-infected macaques for years despite the presence of virulent viral mutants with reduced in vitro susceptibility is...

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

Van Rompay, Koen K. A., Brignolo, Laurie L., Meyer, Dennis J., Jerome, Christopher, Tarara, Ross, Spinner, Abigail, ...

The reverse transcriptase inhibitor 9-[2-(phosphonomethoxy)propyl]adenine (PMPA; tenofovir) was previously found to offer strong prophylactic and therapeutic benefits in an infant macaque model of...

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

Van Rompay, Koen K. A., Brignolo, Laurie L., Meyer, Dennis J., Jerome, Christopher, Tarara, Ross, Spinner, Abigail, ...

Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals

Greenier, Jennifer L, Van Rompay, Koen KA, Montefiori, David, Earl, Patricia, Moss, Bernard, Marthas, Marta L

Rapid Virus Dissemination in Infant Macaques after Oral Simian Immunodeficiency Virus Exposure in the Presence of Local Innate Immune Responses

Abel, Kristina, Pahar, Bapi, Van Rompay, Koen K. A., Fritts, Linda, Sin, Clarissa, Schmidt, Kimberli, ...

A vaccine to protect human immunodeficiency virus (HIV)-exposed infants is an important goal in the global fight against the HIV pandemic. Two major challenges in pediatric HIV vaccine design are the...

Structured Treatment Interruptions with Tenofovir Monotherapy for Simian Immunodeficiency Virus-Infected Newborn Macaques

Van Rompay, Koen K. A., Singh, Raman P., Heneine, Walid, Johnson, Jeffrey A., Montefiori, David C., Bischofberger, Norbert, ...

We demonstrated previously that prolonged tenofovir treatment of infant macaques, starting early during infection with virulent simian immunodeficiency virus (SIVmac251), can lead to persistently low...

Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11

Van Rompay, Koen KA, Blackwood, Emily J, Landucci, Gary, Forthal, Don, Marthas, Marta L

Infection of macaques with the avirulent molecular clone SIVmac1A11 results in transient low viremia and no disease. To investigate if this low viremia is solely due to intrinsic poor replication...

Non-neutralizing antibodies and vaccine-induced protection

Demberg, Thorsten, Florese, Ruth H, Gomez-Roman, V Raul, Larsen, Kay, Van Rompay, Koen KA, Marthas, Marta L, ...

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Van Rompay, Koen KA, Johnson, Jeffrey A, Blackwood, Emily J, Singh, Raman P, Lipscomb, Jonathan, Matthews, Timothy B, ...