An, Dong Sung, Donahue, Robert E., Kamata, Masakazu, Poon, Betty, Metzger, Mark, Mao, Si-Hua, ...
RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions,...
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
Larochelle, André, Krouse, Allen, Metzger, Mark, Orlic, Donald, Donahue, Robert E., Fricker, Simon, ...
AMD3100, a bicyclam antagonist of the chemokine receptor CXCR4, has been shown to induce rapid mobilization of CD34+ hematopoietic cells in mice, dogs, and humans, offering an alternative to G-CSF...
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates
An, Dong Sung, Donahue, Robert E., Kamata, Masakazu, Poon, Betty, Metzger, Mark, Mao, Si-Hua, ...
RNAi is a powerful method for suppressing gene expression that has tremendous potential for therapeutic applications. However, because endogenous RNAi plays a role in normal cellular functions,...
Hsieh, Matthew M., Linde, N. Seth, Wynter, Aisha, Metzger, Mark, Wong, Carol, Langsetmo, Ingrid, ...
The hypoxia-inducible factor (HIF) pathway is crucial in mitigating the deleterious effects of oxygen deprivation. HIF-α is an essential component of the oxygen-sensing mechanisms and under normoxic...