Mark Gabriel

Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein

Taylor, Andrew M, Storm, Janet, Soceneantu, Loredana, Linton, Kenneth J, Gabriel, Mark, Martin, Catherine, ...

Subtle alterations in the coupling of drug binding to nucleotide hydrolysis were observed following mutation of all seven endogenous cysteine residues to serines in the human multidrug resistance...