25 years of HIV-1 research – progress and perspectives (2008)
Wainberg, Mark A, Jeang, Kuan-Teh
Abstract Twenty-five years after the discovery and isolation of the human immunodeficiency virus by French and American scientists, much progress has been made in basic research, clinical treatment,...
Martinez-Cajas, Jorge L, Invernizzi, Cédric F, Ntemgwa, Michel, Schader, Susan M, Wainberg, Mark A
Abstract Objective a) To assess the suitability of the curriculum content and didactical quality of information delivered to educate journalists in the J2J program in HIV/AIDS (process evaluation)...
Journal of the International AIDS Society: an important step forward (2008)
Wainberg, Mark A, Katabira, Elly, Heidari, Shirin
Abstract This editorial welcomes readers to the launch of Journal of the International AIDS society.
Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report (2008)
Quan, Yudong, Brenner, Bluma G, Dascal, André, Wainberg, Mark A
Abstract Background Although drug resistance is a major challenge in HIV therapy, the effect of drug resistance mutations on HIV evolution in vivo is not well understood. We have now investigated...
Whitney, James B, Wainberg, Mark A
Abstract We have analyzed a SIV deletion mutant that was compromised both in viral replication and RNA packaging. Serial passage of this variant in two different T-cell lines resulted in compensatory...
Gayle, Helene, Wainberg, Mark A
Abstract This Commentary reflects on the success of the XVI International Conference on AIDS, that was held in Toronto between August 13–18, 2006. Not only was the Conference judged to have been a...
New pandemics: HIV and AIDS, HCV and chronic hepatitis, Influenza virus and flu (2007)
Gatignol, Anne, Dubuisson, Jean, Wainberg, Mark A, Cohen, Éric A, Darlix, Jean-Luc
Abstract New pandemics are a serious threat to the health of the entire world. They are essentially of viral origin and spread at large speed. A meeting on this topic was held in Lyon, France, within...
HIV-1 subtype C viruses rapidly develop K65R (2006)
Wainberg, Mark A, Doualla-Bell, Florence, Gaolatte, Tedani, Mine, Madisa, Essex, Max, Brenner, Bluma
No abstract available.
Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239 (2006)
Whitney, James B, Wainberg, Mark A
Abstract Background The 5' untranslated region (UTR) or leader sequence of simian immunodeficiency virus (SIV mac239 ) is multifunctional and harbors the regulatory elements for viral replication,...
PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA (2006)
Invernizzi, Cédric F, Xie, Baode, Richard, Stéphane, Wainberg, Mark A
Abstract Background The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich...
Criteria for Drugs Used in Pre-Exposure Prophylaxis Trials against HIV Infection (2006)
Inge Derdelinckx, Mark A. Wainberg, Andrew Hill, Yasmin Halima
The XVI International Conference on AIDS: The place to be! (2006)
Abstract This editorial represents a plea to retrovirologists to attend the XVI International Conference on AIDS that will take place in Toronto, Canada between August 13–18, 2006. In short, it is...
Epidemiology and Evolution of Antiretroviral Drug Resistance (2005)
No abstract available.
Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably? (2004)
Russell, Rodney S, Liang, Chen, Wainberg, Mark A
Abstract During virus assembly, all retroviruses specifically encapsidate two copies of full-length viral genomic RNA in the form of a non-covalently linked RNA dimer. The absolute conservation of...
Arts, Eric J., Albright, Jamie L., Marois, James-Paul, Hough, Charles, Gu, Zhengxian, ...
Difficulties in deciphering the mechanisms of 3'-azido-3'-deoxythymidine (AZT)-resistance by human immunodeficiency virus type 1 (HIV-1) variants are due in part to an inability to reconstitute...
Arts,Eric J., Stetor,Scott R., Li,Xuguang, Rausch,Jason W., Howard,Kathryn J., Ehresmann,Bernard, ...
Arts, Eric J., Stetor, Scott R., Li, Xuguang, Rausch, Jason W., Howard, Kathryn J., Ehresmann, Bernard, ...
Roles of viral and cellular membranes in Sendai virus-mediated cell fusion. (1972)
Thesis--Columbia University.
Borkow, Gadi, Arion, Dominique, Wainberg, Mark A., Parniak, Michael A.
N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide (UC781) is an exceptionally potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse...
De Muys, Jean-Marc, Gourdeau, Henriette, Nguyen-Ba, Nghe, Taylor, Debra L., Ahmed, Parvin S., Mansour, Tarek, ...
The racemic nucleoside analogue 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC) is in clinical development for the treatment of human immunodeficiency virus (HIV) type 1 (HIV-1) infection. dOTC is...
Gu, Zhengxian, Wainberg, Mark A., Nguyen-Ba, Nghe, L’Heureux, Lucille, De Muys, Jean-Marc, Bowlin, Terry L., ...
(−)-β-d-1′,3′-Dioxolane guanosine (DXG) and 2,6-diaminopurine (DAPD) dioxolanyl nucleoside analogues have been reported to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1)....
Richard, Nathalie, Salomon, Horacio, Rando, Robert, Mansour, Tarek, Bowlin, Terry L., Wainberg, Mark A.
Human immunodeficiency virus (HIV) type 1 (HIV-1) variants were selected for resistance to the (+) and (−) enantiomers of a novel nucleoside analogue, 2′-deoxy-3′-oxa-4′-thio-5-fluorocytidine...
Guan, Yongjun, Whitney, James B., Diallo, Karidia, Wainberg, Mark A.
Simian immunodeficiency virus (SIV) infection of macaques is remarkably similar to that of human immunodeficiency virus type 1 (HIV-1) in humans, and the SIV-macaque system is a good model for AIDS...
Hsu, Mayla, Rong, Liwei, Rocquigny, Hugues De, Roques, Bernard P., Wainberg, Mark A.
Interactions between the nucleocapsid protein (NC) and reverse transcriptase of HIV-1 have been shown to promote the initiation of reverse transcription. We assayed the effect of NC on later events,...
The Role of Pr55gag in the Annealing of tRNA3Lys to Human Immunodeficiency Virus Type 1 Genomic RNA
Cen, Shan, Huang, Yue, Khorchid, Ahmad, Darlix, Jean-Luc, Wainberg, Mark A., Kleiman, Lawrence
During human immunodeficiency virus type 1 (HIV-1) assembly, the primer tRNA for the reverse transcriptase-catalyzed synthesis of minus-strand strong-stop cDNA, tRNA3Lys, is selectively packaged into...
Wei, Xin, Götte, Matthias, Wainberg, Mark A.
Reverse transcription of human immunodeficiency virus type-1 is primed by cellular tRNALys3, which is selectively packaged into viral particles where it is bound at its 3′ terminus to a...
Acel, Andrea, Udashkin, Brian E., Wainberg, Mark A., Faust, Emmanuel A.
Cleavage and DNA joining reactions, carried out by human immunodeficiency virus type 1 (HIV-1) integrase, are necessary to effect the covalent insertion of HIV-1 DNA into the host genome. For the...
Huang, Yue, Khorchid, Ahmad, Gabor, Juliana, Wang, Jing, Li, Xuguang, Darlix, Jean-Luc, ...
We have studied the effect of mutations in the human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) sequence on tRNA3Lys genomic placement, i.e., the in vivo placement of primer tRNA3Lys on...
Liang, Chen, Rong, Liwei, Laughrea, Michael, Kleiman, Lawrence, Wainberg, Mark A.
The dimerization initiation site (DIS), downstream of the long terminal repeat within the human immunodeficiency virus type 1 (HIV-1) genome, can form a stem-loop structure (SL1) that has been shown...
Arts, Eric J., Quiñones-Mateu, Miguel E., Albright, Jamie L., Marois, James-Paul, Hough, Charles, Gu, Zhengxian, ...
Difficulties in deciphering the mechanisms of 3′-azido-3′-deoxythymidine (AZT)-resistance by human immunodeficiency virus type 1 (HIV-1) variants are due in part to an inability to reconstitute...
Rong, Liwei, Liang, Chen, Hsu, Mayla, Kleiman, Lawrence, Petitjean, Patrice, De Rocquigny, Hugues, ...
To study the initiation of human immunodeficiency virus type 1 reverse transcription, we have used the viral nucleocapsid protein (NC7) to anneal tRNA3Lys primer onto viral genomic RNA and have then...
Cen, Shan, Khorchid, Ahmad, Gabor, Juliana, Rong, Liwei, Wainberg, Mark A., Kleiman, Lawrence
To study in vivo tRNA3Lys genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1, total viral RNA isolated from either wild-type or...
Götte, Matthias, Arion, Dominique, Parniak, Michael A., Wainberg, Mark A.
Nucleoside analog chain terminators such as 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxy-3′-thiacytidine (3TC) represent an important class of drugs that are used in the clinic to...
Shen, Ni, Jetté, Louis, Liang, Chen, Wainberg, Mark A., Laughrea, Michael
The kissing-loop domain (KLD) encompasses a stem-loop, named kissing-loop or dimerization initiation site (DIS) hairpin (nucleotides [nt] 248 to 270 in the human immunodeficiency virus type 1 strains...
Liang, Chen, Rong, Liwei, Russell, Rodney S., Wainberg, Mark A.
We have studied the role of an RNA region at nucleotides (nt) +200 to +233, just downstream of the 5′ long terminal repeat, in encapsidation of human immunodeficiency virus type 1 genomic RNA....
Liang, Chen, Rong, Liwei, Cherry, Elana, Kleiman, Lawrence, Laughrea, Michael, Wainberg, Mark A.
Previous work has shown that deletions of genomic segments at nucleotide (nt) positions +238 to +253, i.e., construct BH10-LD3, or nt positions +261 to +274, i.e., construct BH10-LD4, within the...
Quan, Yudong, Rong, Liwei, Liang, Chen, Wainberg, Mark A.
We have recently reported that the in vitro inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcription by inhibitors of reverse transcriptase (RT) occurred most efficiently when...
Liang, Chen, Rong, Liwei, Quan, Yudong, Laughrea, Michael, Kleiman, Lawrence, Wainberg, Mark A.
Human immunodeficiency virus type 1 (HIV-1) genomic RNA segments at nucleotide (nt) positions +240 to +274 are thought to form a stem-loop secondary structure, termed SL1, that serves as a...
Guan, Yongjun, Whitney, James B., Detorio, Mervi, Wainberg, Mark A.
We have generated simplified simian immunodeficiency virus (SIV) constructs lacking the nef, vpr, vpx, vif, tat, and rev genes (Δ6 viruses). To accomplish this, we began with an infectious molecular...
Shen, Ni, Jetté, Louis, Wainberg, Mark A., Laughrea, Michael
Stem-loop B is a 12-nucleotide [nt]-long completely conserved sequence postulated to form a 4-bp stem and a 4-nt internal loop under the kissing-loop hairpin (klh) (nt 248 to 270) of human...
Guan, Yongjun, Diallo, Karidia, Detorio, Mervi, Whitney, James B., Liang, Chen, Wainberg, Mark A.
We used the simian immunodeficiency virus (SIV) molecular clone SIVmac239 to generate a deletion construct, termed SD2, in which we eliminated 22 nucleotides at positions +398 to +418 within the...
An Intact U5-Leader Stem Is Important for Efficient Replication of Simian Immunodeficiency Virus
Guan, Yongjun, Diallo, Karidia, Whitney, James B., Liang, Chen, Wainberg, Mark A.
Previous work has shown that four deletions in simian immunodeficiency virus (SIV), termed SD1a, SD1b, SD1c, and SD6, which eliminated sequences at nucleotide positions 322 to 362, 322 to 370, 322 to...
Rong, Liwei, Russell, Rodney S., Hu, Jing, Guan, Yongjun, Kleiman, Lawrence, Liang, Chen, ...
An RNA fragment of 75 nucleotides, which is located between the primer binding site and the 5′ major splice donor site in human immunodeficiency virus type 1, has been shown to participate in...
Kameoka, Masanori, Rong, Liwei, Götte, Matthias, Liang, Chen, Russell, Rodney S., Wainberg, Mark A.
We have examined the role of the human immunodeficiency virus type 1 (HIV-1) Tat protein in the regulation of reverse transcription. We show that a two-exon but not a one-exon form of Tat markedly...
Guan, Yongjun, Whitney, James B., Liang, Chen, Wainberg, Mark A.
We have constructed a series of simian immunodeficiency virus (SIV) mutants containing deletions within a 97-nucleotide (nt) region of the leader sequence. Deletions in this region markedly decreased...
Loemba, Hugues, Brenner, Bluma, Parniak, Michael A., Ma'ayan, Shlomo, Spira, Bonnie, Moisi, Daniela, ...
We sequenced and phylogenetically analyzed the reverse transcriptase (RT) region of five human immunodeficiency virus type 1 isolates from treatment-naive Ethiopian émigrés to Israel. Heteroduplex...
Diallo, Karidia, Oliveira, Maureen, Moisi, Daniela, Brenner, Bluma, Wainberg, Mark A., Götte, Matthias
We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the...
Brenner, Bluma G., Routy, Jean-Pierre, Petrella, Marco, Moisi, Daniela, Oliveira, Maureen, Detorio, Mervi, ...
This study examines the persistence and fitness of multidrug-resistant (MDR) viruses acquired during primary human immunodeficiency virus infection (PHI). In four individuals, MDR infections...
Kameoka, Masanori, Morgan, Max, Binette, Marc, Russell, Rodney S., Rong, Liwei, Guo, Xiaofeng, ...
Human immunodeficiency virus type-1 Tat has been proposed to play a role in the regulation of reverse transcription. We previously demonstrated that wild-type Tat can augment viral infectivity by...
Role of RNA in Facilitating Gag/Gag-Pol Interaction
Khorchid, Ahmad, Halwani, Rabih, Wainberg, Mark A., Kleiman, Lawrence
We have examined the influence of RNA upon the interaction of Gag-Pol with Gag during human immunodeficiency virus type 1 (HIV-1) assembly. COS7 cells were transfected with protease-negative HIV-1...
Matthews, Tim B., Higgins, Joanne, Canfield, Don R., Tarara, Ross P., Wainberg, Mark A., ...
Drug-resistant mutants with a methionine-to-valine substitution at position 184 of reverse transcriptase (M184V) emerged within 5 weeks of initiation of therapy in four newborn macaques infected with...
Liang, Chen, Hu, Jing, Russell, Rodney S., Roldan, Ariel, Kleiman, Lawrence, Wainberg, Mark A.
A 14-amino-acid spacer peptide termed SP1 that separates the capsid (CA) and nucleocapsid (NC) sequences plays an active role in the assembly of human immunodeficiency virus type 1. This activity of...
Whitney, James B., Oliveira, Maureen, Detorio, Mervi, Guan, Yongjun, Wainberg, Mark A.
We previously constructed a series of simian immunodeficiency virus (SIV) mutants containing deletions within a 97-nucleotide region of the SIVmac239 untranslated region or leader sequence. However,...
Russell, Rodney S., Hu, Jing, Bériault, Véronique, Mouland, Andrew J., Kleiman, Lawrence, Wainberg, Mark A., ...
Two copies of human immunodeficiency virus type 1 RNA are incorporated into each virus particle and are further converted to a stable dimer as the virus particle matures. Several RNA segments that...
Xie, Baode, Wainberg, Mark A., Frankel, Alan D.
Human immunodeficiency viruses (HIVs) and the related bovine lentiviruses bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV) utilize the viral Tat protein to activate viral...
Liang, Chen, Hu, Jing, Whitney, James B., Kleiman, Lawrence, Wainberg, Mark A.
Crystal structures of human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) reveal that the last 11 C-terminal amino acids are disordered. This disordered region contains a glycine-rich...
Russell, Rodney S., Hu, Jing, Bériault, Véronique, Mouland, Andrew J., Laughrea, Michael, Kleiman, Lawrence, ...
Quan, Yudong, Brenner, Bluma G., Oliveira, Maureen, Wainberg, Mark A.
The M184V mutation in human immunodeficiency virus (HIV) reverse transcriptase is associated with high-level resistance to both (−)2′,3′-dideoxy-3′-thiacytidine (3TC) and...
Diallo, Karidia, Brenner, Bluma, Oliveira, Maureen, Moisi, Daniela, Detorio, Mervi, Götte, Matthias, ...
The M184V substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), encoding high-level resistance to lamivudine (3TC), results in decreased HIV-1 replicative capacity,...
Diallo, Karidia, Marchand, Bruno, Wei, Xin, Cellai, Luciano, Götte, Matthias, Wainberg, Mark A.
The emergence of drug resistance-conferring mutations can severely compromise the success of chemotherapy directed against human immunodeficiency virus type 1 (HIV-1). The M184V and/or L74V mutation...
Russell, Rodney S., Roldan, Ariel, Detorio, Mervi, Hu, Jing, Wainberg, Mark A., Liang, Chen
Human immunodeficiency virus type 1 encapsidates two copies of viral genomic RNA in the form of a dimer. The dimerization process initiates via a 6-nucleotide palindrome that constitutes the loop of...
Selection of TAR RNA-Binding Chameleon Peptides by Using a Retroviral Replication System
Xie, Baode, Calabro, Valerie, Wainberg, Mark A., Frankel, Alan D.
The interaction between the arginine-rich motif (ARM) of the human immunodeficiency virus (HIV) Tat protein and TAR RNA is essential for Tat activation and viral replication. Two related...
Wainberg, Mark A, Brenner, Bluma G., Daar, Eric, Gertner, Joseph M., Olivier, Clement, Kenley, Susan
We studied the effects of recombinant human growth hormone (r-hGH) on human immunodeficiency virus type 1 replication by growing both wild-type and drug-resistant variants of virus in the presence of...
Turner, Dan, Brenner, Bluma, Moisi, Daniela, Detorio, Mervi, Cesaire, Raymond, Kurimura, Takashi, ...
We have compared nucleotide substitutions and polymorphisms at codons known to confer drug resistance in subtype B strains of human immunodeficiency virus type 1 (HIV-1) with similar substitutions in...