Integrating biological data – the Distributed Annotation System (2008)
Jenkinson, Andrew M, Albrecht, Mario, Birney, Ewan, Blankenburg, Hagen, Down, Thomas, Finn, Robert D, ...
Abstract Background The Distributed Annotation System (DAS) is a widely adopted protocol for dynamically integrating a wide range of biological data from geographically diverse sources. DAS continues...
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Abstract Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This...
Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis (2007)
Cilla Söderhäll, Ingo Marenholz, Tamara Kerscher, Franz Rüschendorf, Jorge Esparza-Gordillo, Margitta Worm, ...
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic...
GOTax: investigating biological processes and biochemical activities along the taxonomic tree (2007)
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
Abstract We describe GOTax, a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins, protein families,...
GOTax: investigating biological processes and biochemical activities along the taxonomic tree (2007)
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
Abstract We describe GOTax, a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins, protein families,...
Combining protein structure prediction with experiments and functional information (2006)
Proteins are key players in all cells of living organisms. In particular, knowledge of the spatial protein structure may give fundamental insights into protein function and disease processes. For...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays (2005)
Costello, Christine M., Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H., Hahn, Andreas, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
An integrative approach to gain insights into the cellular function of human ataxin-2 (2005)
Ralser, Markus, Albrecht, Mario, Nonhoff, Ute, Lengauer, Thomas, Lehrach, Hans, Krobitsch, Sylvia
Spinocerebellar ataxia type 2 (SCA2) is a hereditary neurodegenerative disorder caused by a trinucleotide expansion in the SCA2 gene, encoding a polyglutamine stretch in the gene product ataxin-2...
Ralser, Markus, Nonhoff, Ute, Albrecht, Mario, Lengauer, Thomas, Wanker, Erich E., Lehrach, Hans, ...
Spinocerebellar ataxia type 2 is an inherited neurodegenerative disorder that is caused by an expanded trinucleotide repeat in the SCA2 gene, encoding a polyglutamine stretch in the gene product...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll,Monika, Corneliussen,Brit, Costello,Christine M., Waetzig,Georg H., Mellgard,Bjorn, Koch,W. Andreas, ...
Structural and functional analysis of ataxin-2 and ataxin-3 (2004)
Albrecht,Mario, Golatta,Michael, Wüllner,Ullrich, Lengauer,Thomas
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll, Monika, Corneliussen, Brit, Costello, Christine M., Waetzig, Georg H., Mellgard, Bjorn, Koch, W. Andreas, ...
Structural and functional analysis of ataxin-2 and ataxin-3 (2004)
Albrecht, Mario, Golatta, Michael, Wüllner, Ullrich, Lengauer, Thomas
Simple consensus procedures are effective and sufficient in secondary structure prediction (2003)
Albrecht,Mario, Tosatto,Silvio C.E., Lengauer,Thomas, Valle,Giorgio
Identification of mammalian orthologs associates PYPAF5 with distinct functional roles (2003)
Albrecht,Mario, Domingues,Francisco S., Schreiber,Stefan, Lengauer,Thomas
Structural modeling of ataxin-3 reveals distant homology to adaptins (2003)
Albrecht,Mario, Hoffmann,Daniel, Evert,Bernd O., Schmitt,Ina, Wüllner,Ullrich, Lengauer,Thomas
Simple consensus procedures are effective and sufficient in secondary structure prediction (2003)
Albrecht, Mario, Tosatto, Silvio C.E., Lengauer, Thomas, Valle, Giorgio
Identification of mammalian orthologs associates PYPAF5 with distinct functional roles (2003)
Albrecht, Mario, Domingues, Francisco S., Schreiber, Stefan, Lengauer, Thomas
Structural modeling of ataxin-3 reveals distant homology to adaptins (2003)
Albrecht, Mario, Hoffmann, Daniel, Evert, Bernd O., Schmitt, Ina, Wüllner, Ullrich, Lengauer, Thomas
Improving fold recognition of protein threading by experimental distance constraints (2002)
Albrecht,Mario, Hanisch,Daniel, Zimmer,Ralf, Lengauer,Thomas
Improving fold recognition of protein threading by experimental distance constraints (2002)
Albrecht, Mario, Hanisch, Daniel, Zimmer, Ralf, Lengauer, Thomas
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Castellano, Sergi, Lobanov, Alexey V., Chapple, Charles, Novoselov, Sergey V., Albrecht, Mario, Hua, Deame, ...
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has...
Mutations in the NB-ARC Domain of I-2 That Impair ATP Hydrolysis Cause Autoactivation1[OA]
Tameling, Wladimir I.L., Vossen, Jack H., Albrecht, Mario, Lengauer, Thomas, Berden, Jan A., Haring, Michel A., ...
Resistance (R) proteins in plants confer specificity to the innate immune system. Most R proteins have a centrally located NB-ARC (nucleotide-binding adaptor shared by APAF-1, R proteins, and CED-4)...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Castellano, Sergi, Lobanov, Alexey V., Chapple, Charles, Novoselov, Sergey V., Albrecht, Mario, Hua, Deame, ...
Selenoproteins are a diverse group of proteins that contain selenocysteine (Sec), the 21st amino acid. In the genetic code, UGA serves as a termination signal and a Sec codon. This dual role has...
Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
Plotz, Guido, Welsch, Christoph, Giron-Monzon, Luis, Friedhoff, Peter, Albrecht, Mario, Piiper, Albrecht, ...
MutLα, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch repair. It interacts ATP-dependently with the mismatch detector MutSα and assembles and controls further repair...
Mutations in the NB-ARC Domain of I-2 That Impair ATP Hydrolysis Cause Autoactivation1[OA]
Tameling, Wladimir I.L., Vossen, Jack H., Albrecht, Mario, Lengauer, Thomas, Berden, Jan A., Haring, Michel A., ...
Resistance (R) proteins in plants confer specificity to the innate immune system. Most R proteins have a centrally located NB-ARC (nucleotide-binding adaptor shared by APAF-1, R proteins, and CED-4)...
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
Boeddrich, Annett, Gaumer, Sébastien, Haacke, Annette, Tzvetkov, Nikolay, Albrecht, Mario, Evert, Bernd O, ...
Arginine/lysine-rich motifs typically function as targeting signals for the translocation of proteins to the nucleus. Here, we demonstrate that such a motif consisting of four basic amino acids in...
GOTax: investigating biological processes and biochemical activities along the taxonomic tree
Schlicker, Andreas, Rahnenführer, Jörg, Albrecht, Mario, Lengauer, Thomas, Domingues, Francisco S
GOTax, a novel web-based platform that integrates protein annotation with protein family classification and taxonomy, allows for an extensive assessment of functional similarity between proteins and...
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, ...
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these...
Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis
Söderhäll, Cilla, Marenholz, Ingo, Kerscher, Tamara, Rüschendorf, Franz, Esparza-Gordillo, Jorge, Worm, Margitta, ...
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic...
The implications of alternative splicing in the ENCODE protein complement
Tress, Michael L., Martelli, Pier Luigi, Frankish, Adam, Reeves, Gabrielle A., Wesselink, Jan Jaap, Yeats, Corin, ...
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological...
FunSimMat: a comprehensive functional similarity database
Schlicker, Andreas, Albrecht, Mario
Functional similarity based on Gene Ontology (GO) annotation is used in diverse applications like gene clustering, gene expression data analysis, protein interaction prediction and evaluation....
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Structural analysis of the inhibitor Telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A shows that mutations at V36 and/or T54 result in impaired interaction with VX-950, explaining...